A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies

Abstract

A series of spirooxindole pyrrolidine derivatives has been synthesized and evaluated for theirin vitrobiological activities. The observed regio- and stereoselectivity of the cycloaddition reaction has been rationalized using DFT calculations.

Iterative Arylation of Itaconimides with Diazonium Salts through Electrophilic Palladium Catalysis: Divergent β-H-Elimination Pathways in Repetitive Matsuda–Heck Reactions

“…11 Recently, 3-arylmethylidene pyrrolidine-2,5-diones were investigated as reactants in multicomponent reactions for the synthesis of several interesting spirocyclic scaffolds. [12][13][14][15] Hydrogenation of compounds exo-1 leads to 3-benzyl succinimides, which are also an important structural pattern in medicinal chemistry. For example, compound 2 was identified as an inhibitor of the leukocyte common antigen-related phosphatase, a potential target for the treatment of neurological diseases.…”

Microwave‐assisted synthesis of triazole derivatives conjugated with piperidine as new anti‐enzymatic agents

“…Triazoles and their derived compounds have promising activities in the field of agriculture, medicine, biology, nano‐chemistry, and material science . Triazole‐based compounds have the ability to act as active antiviral, antifungal, antibacterial, anti‐inflammatory, anticonvulsant, and anticancer agents . It is evident from literature review that the triazole‐based derivatives are biologically active compounds and frequently synthesized by using conventional technique.…”

Synthesis, characterization and antimicrobial activities of 1,5-dimethyl-2-phenyl-4-(pyrolidin-2-ylideneamino)-pyrazolidin-3-one and complex with iron(II)

“…Reviewed work has shown that Interesting pharmacological properties have been associated with pyrrolidone and their derivatives. These compounds have shown antimicrobial, antimalarial, anti-inflammatory, antitumor, and anti-parasitic activities (Arun et al, 2013;Bakr et al, 2012;Daferner et al, 2002;Haddad et al, 2015;Ignatova et al, 2007). In view of these, this work is aimed at synthesizing a novel derivative of this ligand, characterized the ligand and the complex and tests their antimicrobial potency.…”