A strategic approach for rapid synthesis of gold and silver nanoparticles by<i>Panax ginseng</i>leaves

Singh, Priyanka; Kim, Yeon Ju; Yang, Deok Chun

doi:10.3109/21691401.2015.1115410

Cited by 183 publications

(85 citation statements)

References 29 publications

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“…This is due to surface plasmon resonance phenomenon of the electrons in the conduction band of silver. The UV-vis spectrometric analysis of the final reaction mixtures TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI showed absorption peaks around 390-415 nm, which are the characteristic peaks for AgNPs ( Figure 5a) in agreement with previous studies with values around 412 nm [64,94]. Soni et al synthesized AgNP with cinnamomum zeylanicum and reported a broad peak at 480 nm [66].…”

Section: Discussionsupporting

confidence: 88%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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Section: Discussionsupporting

confidence: 88%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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“…Ginseng plants show many properties such as antimicrobial, antibacterial and antiviral properties. This plant was used for the synthesis of gold and silver nanoparticles [36]. These nanoparticles were formed by the reduction of auric chloride and silver nitrate, respectively, and they have been studied and found to be resistant toward biofilm produced by microbes.…”

Section: Panax Ginsengmentioning

confidence: 99%

Biological Synthesis of Nanoparticles From Medicinal Plants and Its Uses in Inhibiting Biofilm Formation

Agarwal

Gayathri

2017

Asian J Pharm Clin Res

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Pathogenic micro-organisms have become the main problem in today’s world. All microbes are getting resistant to antibiotics. This is due to theformation of biofilm layer above the micro-organisms. Learning the characteristics of biofilm can help us in treating the infectious disease induced via micro-organisms. They affect human’s life in some or the other way. For example, the plaque formed in our teeth that cause tooth decay is due to thebacterial biofilm. When micro-organisms stick to moist or wet surfaces, it produces glue-like, slimy contents which are known as biofilms. Biofilmsbelong to the sessile communities, communities in which organisms are considered as immobile. Biofilms are enclosed within a matrix, known asextracellular polymeric matrix, which are secreted by micro-organisms. Biofilms attached to the surfaces are affected by certain characteristics likethe growth medium, substratum to which it is attached and cellular surfaces. Each of these factors can either increase or decrease the hold of biofilmon the surfaces. With the help of biofilms, micro-organisms protect themselves from antibiotics and cause various infectious disease. Recent studies had proved medicinal plants to be effective in treating disease caused by microbes. Medicinal plants produce active compounds during secondarymetabolism which help in the treatment of infectious disease. The problem that arises with antibiotics is that they are unable to penetrate through thebiofilm. This problem is solved by converting antibiotics in nanoparticle size. Nanoparticles have high penetrating ability than the antibiotics. Theyhelp in controlling microbial growth by killing them.Keywords: Medicinal plants, Nanoparticles, Biofilm.

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“…25 FE-TEM was used to analyze the selected area (electron) diffraction (SAED) and fast Fourier transform (FFT) pattern of BSA-Rh2 NPs. 26 The hydrodynamic particle size distribution, polydispersity index, and zeta potential were analyzed using a DLS instrument at 25°C (Photal or Otsuka Electronics, Hirakata, Japan). The BSA-Rh2 NPs sample was dispersed in water, as a reference, a dispersive medium of pure water with a refractive index of 1.3328, viscosity of 0.8878, and dielectric constant of 78.3 was used.…”

Section: −1mentioning

confidence: 99%

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

Singh¹,

Kim²,

Singh³

et al. 2017

IJN

Self Cite

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The present study investigates a simple and convenient one-step procedure for the preparation of bovine serum albumin (BSA)-Rh2 nanoparticles (NPs) at room temperature. In this work, ginsenoside Rh2 was entrapped within the BSA protein to form BSA-Rh2 NPs to enhance the aqueous solubility, stability, and therapeutic efficacy of Rh2. The physiochemical characterization by high-performance liquid chromatography, nuclear magnetic resonance, Fourier transform infrared spectroscopy, field emission transmission electron microscopy, dynamic light scattering, and thermogravimetric analysis confirmed that the prepared BSA-Rh2 NPs were spherical, highly monodispersed, and stable in aqueous systems. In addition, the stability of NPs in terms of different time intervals, pHs, and temperatures (20°C–700°C) was analyzed. The results obtained with different pHs showed that the synthesized BSA-Rh2 NPs were stable in the physiological buffer (pH 7.4) for up to 8 days, but degraded under acidic conditions (pH 5.0) representing the pH inside tumor cells. Furthermore, comparative analysis of the water solubility of BSA-Rh2 NPs and standard Rh2 showed that the BSA nanocarrier enhanced the water solubility of Rh2. Moreover, in vitro cytotoxicity assays including cell viability assays and morphological analyses revealed that Rh2-entrapped BSA NPs, unlike the free Rh2, demonstrated better in vitro cell viability in HaCaT skin cell lines and that BSA enhanced the anticancer effect of Rh2 in A549 lung cell and HT29 colon cancer cell lines. Additionally, anti-inflammatory assay of BSA-Rh2 NPs and standard Rh2 performed using RAW264.7 cells revealed decreased lipopolysaccharide-induced nitric oxide production by BSA-Rh2 NPs. Collectively, the present study suggests that BSA can significantly enhance the therapeutic behavior of Rh2 by improving its solubility and stability in aqueous systems, and hence, BSA-Rh2 NPs may potentially be used as a ginsenoside delivery vehicle in cancer and inflammatory cell lines.

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A strategic approach for rapid synthesis of gold and silver nanoparticles byPanax ginsengleaves

Cited by 183 publications

References 29 publications

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Biological Synthesis of Nanoparticles From Medicinal Plants and Its Uses in Inhibiting Biofilm Formation

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

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