A straightforward method for quantification of vinyl functionalized water soluble alginates via 13C-NMR spectroscopy

Stubbe, Birgit; Graulus, Geert-Jan; Reekmans, Gunter; Courtin, Timothee; Martins, José; Vlierberghe, Sandra Van; Dubruel, Peter; Adriaensens, Peter

doi:10.1016/j.ijbiomac.2019.05.015

Cited by 7 publications

(7 citation statements)

References 63 publications

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“…After dialysis, the samples were freeze‐dried using a Christ freeze‐dryer alpha 2‐4 LSC. To obtain a sheet, UV cross‐linking of a 5% w/w methacrylated alginate solution was performed for 1.5 h. [ 33 ]…”

Section: Methodsmentioning

confidence: 99%

“…[ 29 ] These hydrogel precursors can be based on different polymer backbones, poly(ethylene glycol) (PEG) being one example only. [ 29,31–33 ] Cross‐linking in the solid state is promoted by the introduction of a flexible spacer which is linked to the backbone polymer by means of a di‐isocyanate (isophorone di‐isocyanate (IPDI)) (see Figure ). [ 29,31 ]…”

Section: Introductionmentioning

confidence: 99%

“…[29] These hydrogel precursors can be based on different polymer backbones, poly(ethylene glycol) (PEG) being one example only. [29,[31][32][33] Cross-linking in the solid state is promoted by the introduction of a flexible spacer which is linked to the backbone polymer by means of a di-isocyanate (isophorone di-isocyanate (IPDI)) (see Figure 1). [29,31] Alginate is already being used in commercial wound dressings (e.g., Kaltostat, Algosteril, Carboflex) as it is capable of absorbing large amounts of exudate.…”

Section: Introductionmentioning

confidence: 99%

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Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds

Minsart

Mignon

Arslan

et al. 2020

Macro Materials & Eng

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Malodorous wounds have a detrimental effect on the patient's well‐being. A dressing combining the properties of hydrogels and activated carbon (AC) would be beneficial for the treatment of these wounds, controlling wound exudate while adsorbing malodor‐causing compounds. The present work involves the use of acrylate‐endcapped, urethane‐based precursors (AUPs) and methacrylated alginate (AlgMOD). AUPs are synthesized with a varying poly(ethylene glycol) backbone molar mass (2–20 kg mol−1) to tune mechanical and swelling properties, whereas methacrylated alginate, known for its hemostatic properties, enables chemical cross‐linking. Blends of AUP and AlgMOD with AC are processed into hydrogel sheets and electrospun membranes. The results indicate tunable mechanical (Young's moduli 0.03–0.63 MPa) and swelling properties (2.2–34.9 gwater ) along with high gel fractions (>85%). The sheets are compared with commercial odor‐adsorbing dressings (Carbonet and Carboflex), enabling benchmarking. AUP sheets (8 and 10 kg mol−1) containing 0.5% w/w AC show strong adsorption (>90% after 24 h) of crystal violet. The obtained (core–shell AlgMOD/AUP) fibers are visualized using scanning and transmission electron microscopy. Indirect cell tests reveal the developed materials to be biocompatible. In conclusion, a hydrogel‐based odor‐adsorbing wound dressing is successfully synthesized and holds promise for malodorous wound healing.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds

Minsart

Mignon

Arslan

et al. 2020

Macro Materials & Eng

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“…The determination of the degree of substitution of Alg‐MA was previously described . In short: quantitative 13 C‐NMR spectra were acquired on a 300 MHz Varian Inova spectrometer with an Auto SW PFG probe.…”

Section: Methodsmentioning

confidence: 99%

Development of Gelatin‐Alginate Hydrogels for Burn Wound Treatment

Stubbe

Mignon

Declercq

et al. 2019

Macromolecular Bioscience

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Hydrogels are interesting as wound dressing for burn wounds to maintain a moist environment. Especially gelatin and alginate based wound dressings show strong potential. Both polymers are modified by introducing photocrosslinkable functionalities and combined to hydrogel films (gel‐MA/alg‐MA). In one protocol gel‐MA films are incubated in alg‐MA solutions and crosslinked afterward into double networks. Another protocol involves blending both and subsequent photocrosslinking. The introduction of alginate into the gelatin matrix results in phase separation with polysaccharide microdomains in a protein matrix. Addition of alg(‐MA) to gel‐MA leads to an increased swelling compared to 100% gelatin and similar to the commercial Aquacel Ag dressing. In vitro tests show better cell adhesion for films which have a lower alginate content and also have superior mechanical properties. The hydrogel dressings exhibit good biocompatibility with adaptable cell attachment properties. An adequate gelatin‐alginate ratio should allow application of the materials as wound dressings for several days without tissue ingrowth.

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“…In this manner, the alginate chains will contain methacrylate groups used in the polymerization process via free radicals. The alginate reaction occurs preferentially in the C-2 hydroxyl group of a mannuronic acid residue, however, taking into account its similar reactivity, the C-3 hydroxyl group of mannuronic acid is also prone to methacrylation, in addition to the residues hydroxyl present in the guluronic acid units (see Figure 1) 15 . The resulting macromonomer (AlgMA) was characterized by Fourier Transformed Infrared spectroscopy (FTIR), and 1 H-NMR.…”

Section: Algma Macromonomer Characterizationmentioning

confidence: 99%

Oscillatory Strain Sweeps of Hydrogels From Methacrylated Alginate Macromonomers: Assessment of Synthesis and Acquisition Variables

Solar¹,

Palacio²,

Sánchez³

et al. 2019

J. Chil. Chem. Soc.

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The objective of this study is the rheological characterization of photocrosslinked alginate hydrogels synthesized from methacrylated alginate macromonomers. We first optimized the rheological acquisition parameters for this hydrogels, that is, we studied the influence of the geometries diameter, distance between plates (gap), and solvent trap in the rheological response. Our results show important variations of shear storage modulus, G', and yield strain with the three parameters measured. Secondly, with the optimized experimental parameters, rheological tests were performed on hydrogels synthesized under different conditions. Three parameters were studied; UV exposure time (polymerization time), macromonomer concentration and photoinitiator concentration. Our data indicate that the polymerization time and the macromonomer concentration have an important effect on the viscoelastic properties of the hydrogel, significantly modifying the shear storage modulus, G', and the yield strain while the photoinitiator concentration did not influence the viscoelastic properties.

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A straightforward method for quantification of vinyl functionalized water soluble alginates via 13C-NMR spectroscopy

Cited by 7 publications

References 63 publications

Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds

Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds

Development of Gelatin‐Alginate Hydrogels for Burn Wound Treatment

Oscillatory Strain Sweeps of Hydrogels From Methacrylated Alginate Macromonomers: Assessment of Synthesis and Acquisition Variables

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