A stimulus-responsive magnetic nanoparticle drug carrier: Magnetite encapsulated by chitosan-grafted-copolymer

Yuan, Quan; Venkatasubramanian, R.; Hein, San; Misra, R.D.K.

doi:10.1016/j.actbio.2008.02.002

Cited by 223 publications

(101 citation statements)

References 47 publications

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“…Several groups have shown the formation of a novel drug delivery device with magnetic targeting capability by coating a magnetic nanoparticle, conjugated to active drug, with a thermoresponsive polymer. Upon heating above the LCST, the coating shrinks and releases the active drug [149,151,152,155,156]. Purushotham also showed the possibility of using a magnetic field to heat the composite and hence release entrapped drugs form the thermoresponsive coating [150].…”

Section: Particlesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Particlesmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…A variety of smart CAs have been developed that become activated in response to changes in pH, [7][8][9][10][11][12][13] to the presence of metal ions [14][15][16] through enzymatic activation, 17 and to the presence of oxygenated hemoglobin 18 or radicals 19 or upon exposure to ultrasounds 20 or changes in temperature. 21,22 These smart CAs have proven to be excellent MRI tools for very specific targets in vitro and in vivo. 7,8 On the other hand, targeted nanoparticles such as liposomes, 23 dendrimers, 24 and micelles provide several unique features and capabilities such as to house a large number or different types of functional groups that can be used in multiple diagnostic (eg, gadolinium complex) and therapeutic (eg, anticancer) agents.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging

Mouffouk

Dornelle

Lopes

et al. 2014

IJN

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Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol- b -trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ( t BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that t BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35–40 nm) reveals their potential use for early cancer detection by MRI.

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“…The developed smart polymer exhibited a LCSTof 38 C. The drug releasewas appreciably low below the LCSTas opposed to temperatures above the LCST. In each case, there was an initial rapid drug release, followed by a controlled release in a second stage, especially in a mild acidic buffer solution [126].…”

Section: Chitosan-grafted Thermosensitive Polymersmentioning

confidence: 99%

“…A novel magnetic nanoparticle drug carrier for controlled drug release has been reported to respond to changes in external temperature or pH, resulting in longer circulation time and reduced side effects of the delivered drug (doxorubicin) as compared to the native drug [126]. The novel nanocarrier is described as a functionalized magnetite (Fe 3 O 4 ) core that is conjugated with doxorubicin via an acid-labile hydrazone bond and encapsulated by the thermosensitive smart polymer, chitosan-g-poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide).…”

Section: Chitosan-grafted Thermosensitive Polymersmentioning

confidence: 99%