A stereotactic method for image-guided transcranial magnetic stimulation validated with fMRI and motor-evoked potentials

Neggers, Sebastiaan F. W.; Langerak, Thomas; Schutter, Dennis J.L.G.; Mandl, René C.W.; Ramsey, Nick F.; Lemmens, Peter; Postma, Albert

doi:10.1016/j.neuroimage.2003.12.006

Cited by 114 publications

(89 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Voxels with the maximum T-value in the statistical T-map (in unnormalized individual "native" space) were chosen near the midsagittal plane within the SEF so that the SEFs in both hemispheres could be targeted by TMS. The site of stimulation on each participant's scalp was determined using our stereotactic fMRI-guided neural navigation software (The Neural Navigator, NeNa 1.5; Brain Science Tools BV, The Netherlands) and a magnetic tracking system (DriveBAY; Ascension Technology) (36). We also stimulated the "vertex" as a control region, defined as the location on the scalp that was the most superior when the participant was sitting upright and looking straight ahead.…”

Section: Methodsmentioning

confidence: 99%

Proactive control of sequential saccades in the human supplementary eye field

Sharika

Neggers

Gutteling

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Our ability to regulate behavior based on past experience has thus far been examined using single movements. However, natural behavior typically involves a sequence of movements. Here, we examined the effect of previous trial type on the concurrent planning of sequential saccades using a unique paradigm. The task consisted of two trial types: no-shift trials, which implicitly encouraged the concurrent preparation of the second saccade in a subsequent trial; and target-shift trials, which implicitly discouraged the same in the next trial. Using the intersaccadic interval as an index of concurrent planning, we found evidence for contextbased preparation of sequential saccades. We also used functional MRI-guided, single-pulse, transcranial magnetic stimulation on human subjects to test the role of the supplementary eye field (SEF) in the proactive control of sequential eye movements. Results showed that (i) stimulating the SEF in the previous trial disrupted the previous trial type-based preparation of the second saccade in the nonstimulated current trial, (ii) stimulating the SEF in the current trial rectified the disruptive effect caused by stimulation in the previous trial, and (iii) stimulating the SEF facilitated the preparation of second saccades based on previous trial type even when the previous trial was not stimulated. Taken together, we show how the human SEF is causally involved in proactive preparation of sequential saccades.performance monitoring | delayed saccade double-step task | oculomotor | parallel programming | cognitive control T he medial frontal cortex has previously been implicated in our ability to regulate behavior based on past experience. For example, in the case of eye movements, the supplementary eye fields (SEFs) are involved in preparing a saccade in a given trial taking into account information related to preceding trials (1-3). Such contextual control is pivotal in generating optimal responses in a dynamically changing environment and may derive from signals that are sensitive to conflict or errors in previous trials (1-11). Although studies centered on proactive control have so far focused on the regulation of single movements or simple responses, natural behavior typically involves the execution of multiple movements in a sequence. Using a modified version of the classic double-step paradigm called the delayed saccade double-step task, we tested the role of previous trial type in modulating the concurrent planning of sequential eye movements (experiment 1). Also, using functional MRI (fMRI)-guided, single-pulse, transcranial magnetic stimulation (TMS), we investigated the role of SEF in the proactive planning of sequential saccades (experiment 2) i.e., whether the SEF is causally involved in embedding contextual information about the previous trial for the preparation of future sequential movements. In the process, we attempt to provide a link between apparently diverse functions of the SEF, such as planning of saccade sequences (12, 13) and conflict monitoring (1-3).The delayed...

show abstract

Section: Methodsmentioning

confidence: 99%

Proactive control of sequential saccades in the human supplementary eye field

Sharika

Neggers

Gutteling

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…35,36 In the late 1990s and early 2000s, a combination of TMS with optically tracked stereotactic navigation systems was established, whereby it was possible to visualize the stimulation sites via the 3D reconstructed MRI data of the patient's brain. 31,37 Thus, the door to the operating theater was opened since the recorded and analyzed stimulation sites could be used for presurgical planning and data could be abbreviatioNs BOLD = blood-oxygen-level dependent; CPS = cortical parcellation system; DCS = direct cortical stimulation; DTI-FT = diffusion tensor imaging fiber tracking; fMRI = functional MRI; NPV = negative predictive value; PPV = positive predictive value; PTI = picture-to-trigger interval; RMT = resting motor threshold; ROC = receiver operating characteristic; rTMS = repetitive navigated TMS; TMS = transcranial magnetic stimulation. (rTMS) is increasingly used and has already replaced functional MRI (fMRI) in some institutions for preoperative mapping of neurosurgical patients.…”

mentioning

confidence: 99%

Impairment of preoperative language mapping by lesion location: a functional magnetic resonance imaging, navigated transcranial magnetic stimulation, and direct cortical stimulation study

Ille¹,

Sollmann²,

Hauck³

et al. 2015

JNS

View full text Add to dashboard Cite

Since transcranial magnetic stimulation (TMS) was introduced for stimulating the human motor cortex by Barker et al. in 1985, the method has become more sophisticated and was extensively refined.1 PascualLeone and colleagues introduced the term "virtual lesion" and were already in 1991 able to induce speech arrests and counting errors by the use of rapid-rate TMS. 35,36 In the late 1990s and early 2000s, a combination of TMS with optically tracked stereotactic navigation systems was established, whereby it was possible to visualize the stimulation sites via the 3D reconstructed MRI data of the patient's brain. 31,37 Thus, the door to the operating theater was opened since the recorded and analyzed stimulation sites could be used for presurgical planning and data could be abbreviatioNs BOLD = blood-oxygen-level dependent; CPS = cortical parcellation system; DCS = direct cortical stimulation; DTI-FT = diffusion tensor imaging fiber tracking; fMRI = functional MRI; NPV = negative predictive value; PPV = positive predictive value; PTI = picture-to-trigger interval; RMT = resting motor threshold; ROC = receiver operating characteristic; rTMS = repetitive navigated TMS; TMS = transcranial magnetic stimulation. (rTMS) is increasingly used and has already replaced functional MRI (fMRI) in some institutions for preoperative mapping of neurosurgical patients. Yet some factors affect the concordance of both methods with direct cortical stimulation (DCS), most likely by lesions affecting cortical oxygenation levels. Therefore, the impairment of the accuracy of rTMS and fMRI was analyzed and compared with DCS during awake surgery in patients with intraparenchymal lesions. methods Language mapping was performed by DCS, rTMS, and fMRI using an object-naming task in 27 patients with left-sided perisylvian lesions, and the induced language errors of each method were assigned to the cortical parcellation system. Subsequently, the receiver operating characteristics were calculated for rTMS and fMRI and compared with DCS as ground truth for regions with (w/) and without (w/o) the lesion in the mapped regions. results The w/ subgroup revealed a sensitivity of 100% (w/o 100%), a specificity of 8% (w/o 5%), a positive predictive value of 34% (w/o: 53%), and a negative predictive value (NPV) of 100% (w/o: 100%) for the comparison of rTMS versus DCS. Findings for the comparison of fMRI versus DCS within the w/ subgroup revealed a sensitivity of 32% (w/o: 62%), a specificity of 88% (w/o: 60%), a positive predictive value of 56% (w/o: 62%), and a NPV of 73% (w/o: 60%). coNclusioNs Although strengths and weaknesses exist for both rTMS and fMRI, the results show that rTMS is less affected by a brain lesion than fMRI, especially when performing mapping of language-negative cortical regions based on sensitivity and NPV.

show abstract

“…Although this method was sufficient to elicit all previous positive effects, [25][26][27][28] the use of a stereotactic neuronavigation technique based on an individual's structural MRI scan may be superior to position the coil at the target site. [45][46][47][48][49] However, our group has previously performed 2 neuro-navigated rTMS trials which found no difference between active and sham treatment. 15,50 In addition, although the left temporoparietal area is used as a target site for stimulation in the majority of rTMS designs for AVH, 18 many other brain regions are also associated with AVH experience including right-sided language-related areas.…”

Section: Strengths and Limitationsmentioning

confidence: 87%

Theta Burst Transcranial Magnetic Stimulation for Auditory Verbal Hallucinations: Negative Findings From a Double-Blind-Randomized Trial

Koops

Dellen

Schutte

et al. 2015

SCHBUL

View full text Add to dashboard Cite

Background. Auditory verbal hallucinations (AVH) in schizophrenia are resistant to antipsychotic medication in approximately 25% of patients. Treatment with repetitive transcranial magnetic stimulation (rTMS) for refractory AVH has shown varying results. A stimulation protocol using continuous theta burst rTMS (TB-rTMS) showed high efficacy in open label studies. We tested TB-rTMS as a treatment strategy for refractory AVH in a doubleblind, placebo-controlled trial. Methods. Seventy-one patients with AVH were randomly allocated to TB-rTMS or placebo treatment. They received 10 TB-rTMS or sham treatments over the left temporoparietal cortex in consecutive days. AVH severity was assessed at baseline, end of treatment and follow-up using the Psychotic Symptom Rating Scale (PSYRATS) and the Auditory Hallucinations Rating Scale (AHRS). Other schizophrenia-related symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Results. Seven patients dropped out before completing the study. In the remaining 64, AVH improved significantly after treatment in both groups as measured with both PSYRATS and AHRS. PANSS positive and general subscores also decreased, but the negative subscores did not. However, improvement did not differ significantly between the TB-rTMS and the placebo group on any outcome measure. Conclusions. Symptom reduction could be achieved in patients with medication-resistant hallucinations, even within 1 week time. However, as both groups showed similar improvement, effects were general (ie, placeboeffects) rather than specific to treatment with continuous TB-rTMS. Our findings highlight the importance of double-blind trials including a sham-control condition to assess efficacy of new treatments such as TMS.

show abstract

A stereotactic method for image-guided transcranial magnetic stimulation validated with fMRI and motor-evoked potentials

Cited by 114 publications

References 30 publications

Proactive control of sequential saccades in the human supplementary eye field

Proactive control of sequential saccades in the human supplementary eye field

Impairment of preoperative language mapping by lesion location: a functional magnetic resonance imaging, navigated transcranial magnetic stimulation, and direct cortical stimulation study

Theta Burst Transcranial Magnetic Stimulation for Auditory Verbal Hallucinations: Negative Findings From a Double-Blind-Randomized Trial

Contact Info

Product

Resources

About