A stereological study of MRI and the Cavalieri principle combined for diagnosis and monitoring of brain tumor volume

Sönmez, Osman Fikret; Odacı, Ersan; Baş, Orhan; Çolakoğlu, Serdar; Şahin, Bünyamin; Bilgiç, Sait; Kaplan, Süleyman

doi:10.1016/j.jocn.2010.03.044

Cited by 20 publications

(17 citation statements)

References 41 publications

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“…This volumetric stereological measurement technique has been used for estimation of brain volume and recommended for clinical use in elderly people with dementia (25). The method has been used also in the evaluation of tumor volume from MRI images and again recommended for clinical use (26). The counting procedure lasted on average approximately 10 minutes per patient.…”

Section: Discussionmentioning

confidence: 99%

Effect of Skull Type on the Relative Size of Cerebral Cortex and Lateral Ventricles in Dogs

et al. 2017

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Volume measurements of the brain are of interest in the diagnosis of brain pathology. This is particularly so in the investigation hydrocephalus and canine cognitive dysfunction (CCD), both of which result in thinning of the cerebral cortex and enlarged ventricles. Volume assessment can be made using computed tomography or more usually magnetic resonance imaging (MRI). There is, however, some uncertainty in the interpretation of such volume data due to the great variation in skull size and shape seen in dog. In this retrospective study, we examined normal MRI images from 63 dogs <6 years of age. We used a continuous variable, the cranial index (CrI) to indicate skull shape and compared it with MRI volume measurements derived using Cavalieri’s principle. We found a negative correlation between CrI and the ratio of cortical to ventricular volume. Breeds with a high CrI (large laterolateral compared to rostrocaudal cranial cavity dimension) had a smaller ratio of cortical to ventricular volume (low C:V ratio) than breeds with lower CrI skull types. It is important to consider this effect of skull shape on the relative volume estimates of the cerebral cortex and ventricles when trying to establish if pathology is present.

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Section: Discussionmentioning

confidence: 99%

Effect of Skull Type on the Relative Size of Cerebral Cortex and Lateral Ventricles in Dogs

et al. 2017

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“…For each brain region, we analyzed five sections / individual, and studied at least six mice / cohort. For stereology analysis, we used the Cavalieri method (61). Briefly, the region of interest in each section was selected with a 4x objective on an Olympus BX55 microscope (Olympus, Denmark).…”

Section: Methodsmentioning

confidence: 99%

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

et al. 2012

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Huntington’s disease (HD) is caused by CAG / polyglutamine repeat expansions in the huntingtin (htt) gene, yielding proteins that misfold and resist degradation. HD belongs to a large class of neurodegenerative proteinopathies including Alzheimer’s disease, Parkinson’s disease, and tauopathies. Previous studies demonstrated that mutant htt interferes with transcriptional programs coordinated by PPARγ co-activator 1α (PGC-1α), a regulator of mitochondrial biogenesis and oxidative stress. To test if restoration of PGC-1α could treat HD, we attempted an in vivo genetic rescue in mice. We found that PGC-1α induction ameliorates HD neurodegeneration and virtually eliminates htt protein aggregation, in part by attenuating oxidative stress. Further studies revealed that PGC-1α promotes htt turnover and aggregate elimination by transactivation of TFEB, a master regulator of the autophagy-lysosome pathway, and that TFEB alone is capable of reducing htt aggregation and neurotoxicity, placing PGC-1α upstream of TFEB. PGC-1α and TFEB thus hold great promise as therapies for HD and other neurodegenerative proteinopathies.

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“…For striatal volume, the Cavalieri principle was employed where the total striatal area was multiplied by section thickness (25 μm) and sectional sampling interval (Kennedy et al, 1999) as previously described (Mayhew and Olsen, 1991;Sonmez et al, 2010). 3 months: 20 WT, 20 Casp6−/−, 21 YAC128 and 19 YAC128/Casp6−/−.…”

Section: Stereologymentioning

confidence: 99%

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Wong

Ehrnhoefer

Graham

et al. 2015

Neurobiology of Disease

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A stereological study of MRI and the Cavalieri principle combined for diagnosis and monitoring of brain tumor volume

Cited by 20 publications

References 41 publications

Effect of Skull Type on the Relative Size of Cerebral Cortex and Lateral Ventricles in Dogs

Effect of Skull Type on the Relative Size of Cerebral Cortex and Lateral Ventricles in Dogs

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

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