A step forward in the development of superoxide dismutase mimetic nanozymes: the effect of the charge of the surface on antioxidant activity

Abstract

Binuclear Cu2+ complexes of a pyridinophane polyamine ligand grafted to boehmite nanoparticles show a remarkable increase in SOD activity, which can be ascribed to the positive ζ-potential of the nanoparticles.

Superoxide dismutase nanozymes: an emerging star for anti-oxidation

“…À to the active centers, consistent with the active sites of natural enzymes. 128 However, there are few studies on the use of natural enzyme active centers to guide the activity of nanozymes, and we look forward to the review of this article to provide more ideas for future. For example, the active centers of SOD are mostly composed of metal ions coordinated by C, N, O and other elements of surrounding amino acids.…”

An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies

“…20 Although to the best of our knowledge very few of such systems have shown a satisfactory clinical effect, 3,11,21 tetraazamacrocycles, on the one side, and nanotechnology, on the other one, are arising as potential therapeutics for neurodegenerative disorders where oxidative stress is involved. 15–18,22–25 In this context, we have recently found that decoration of non-toxic boehmite nanoparticles (BNPs) with binuclear Cu 2+ azamacrocycles leads to a striking enhancement of the SOD activity of such complexes. 23,24,26 It should be finally taken into account that, despite the high value of the catalytic constant shown by the above-mentioned SOD mimetics, if they are not able to revert the generation of mHTT aggregates, such SOD scavengers would be of little use in the treatment of HD.…”

“…15–18,22–25 In this context, we have recently found that decoration of non-toxic boehmite nanoparticles (BNPs) with binuclear Cu 2+ azamacrocycles leads to a striking enhancement of the SOD activity of such complexes. 23,24,26 It should be finally taken into account that, despite the high value of the catalytic constant shown by the above-mentioned SOD mimetics, if they are not able to revert the generation of mHTT aggregates, such SOD scavengers would be of little use in the treatment of HD. 21 Though some successful attempts have been done in this sense for Alzheimer, 27 scarce success has been achieved for HD.…”

“…1), a nanozyme based on the structure of an azamacrocycle ( L2 ) whose Cu 2+ complexes present a remarkable activity. 15,22–24 Thus, we have introduced in its structure a withdrawing group in position 4 of the pyridine to reduce the stability of the Cu 2+ complexes, so that the SOD activity would be facilitated (it would help the cycling between oxidation states II and I of copper required for the dismutation of superoxide to occur). 15,22 Moreover, in this way we also provided the macrocycle with a more robust grafting group than those previously reported, without significantly altering the geometry of the resulting Cu 2+ complexes.…”

“…15,22 Moreover, in this way we also provided the macrocycle with a more robust grafting group than those previously reported, without significantly altering the geometry of the resulting Cu 2+ complexes. 23,24 To check our hypothesis, in this work we study the capacity of the ligand to coordinate Cu 2+ and we determine the SOD activity of the resulting complexes, both free in solution and anchored onto BNPs. Finally, we also evaluate the in vitro capacity of the synthesized compounds both in reducing mitochondria oxidative stress and in disaggregating mHTT.…”