A step-down experience in asthma treatment: a retrospective cohort study

Öztürk, Betül Özdel; Sözener, Zeynep Çelebi; Aydın, Ömür; Mungan, Dilşad

doi:10.1080/02770903.2021.1895211

Cited by 1 publication

(1 citation statement)

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“…All patients who were diagnosed with asthma according to the GINA criteria (13) and were followed up with a diagnosis of asthma for at least one year with complete file records in our specialized asthma follow-up outpatient clinic were included in the study. Our asthma follow-up clinic is an important and experienced center in the field of asthma diagnosis and management and is one of the leading referral centers located in the capital of our country (11,(14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Study Group and Data Recordingmentioning

confidence: 99%

Overview of asthma patients followed up in a Tertiary Clinic

Sözener

Öztürk

Aydın

et al. 2023

Eur Ann Allergy Clin Immunol

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Background. Asthma is a disease that combines different biological mechanisms, inflammatory pathways, and phenotypic features. Our aim was to investigate the demographic and disease characteristics of patients with asthma and to reveal the distribution with different phenotypes according to endotype groups. Methods. Patients were identified as eosinophilic if the absolute eosinophil count was measured at least once ≥ 300/μL during the oral corticosteroid free period or ≥ 150/μL under oral corticosteroids. Patients sensitive to at least one inhalant allergen with skin prick test and/ or spIgE measurement were defined as allergic. They were categorized into four main endotypes. Results. Data of 405 asthma patients with a median age of 50.9 years were analyzed. The prominent clinical and phenotypic characteristics of the study group were being obese (43.2%) or overweight (32%), severe asthma (49.6%), adult-onset (56.1%) or late-onset asthma (35.3%). The distribution of the four main endotypes according to eosinophilic and/or allergic status, is as follows: 22.7% allergic-eosinophilic (AE), 27.9% nonallergic-eosinophilic (NAE), 22.9% allergic-noneosinophilic (ANE), 26.4% nonallergic-noneosinophilic (NANE). While most severe asthma patients were in the AE and NAE groups, those with early-onset asthma were in AE and ANE, and those with late-onset asthma were in the NAE and NANE groups. The proportion of uncontrolled patients was higher in the NAE group. Among the severe asthma patients, the rate of uncontrolled disease was higher in those with NANE asthma. Conclusions. Different phenotypes were more closely related to some endotypes. This may allow the clinicians to identify patients and predict appropriate treatment modalities and response for individualized care. Impact statementEndotypes of asthma were examined according to asthma severity, age of asthma onset, control status and obesity subgroups in a tertiary clinic.We found that severe asthmatics were mostly eosinophilic, majority of patients with early-onset asthma were allergic, late-onset asthmatics and obese patients were mostly nonallergic and the proportion of uncontrolled patients was higher in the nonallergic-eosinophilic group.

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