A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode

Painold, Annamaria; Mörkl, Sabrina; Kashofer, Karl; Halwachs, Bettina; Dalkner, Nina; Bengesser, Susanne; Birner, Armin; Fellendorf, Frederike T.; Platzer, Martina; Queissner, Robert; Schütze, Gregor; Schwarz, Markus J.; Moll, Natalie; Holzer, Peter; Holl, Anna K.; Kapfhammer, Hans-Peter; Gorkiewicz, Gregor; Reininghaus, Eva

doi:10.1111/bdi.12682

Cited by 164 publications

(189 citation statements)

References 59 publications

Supporting

Mentioning

172

Contrasting

Order By: Relevance

“…Dorea is reported to reduce in abundance in IBD or patients with Parkinson's disease [25,26]. Collinsella belongs to Coriobacteriia, which is reported to be associated with bipolar disorder and the related neural in ammation [27]. Eubacterium ventriosum group was negatively correlated with depression and anxiety levels in the current study, in consistency with previous reports of lower Eubacterium in UC and bipolar patients [28,29].…”

Section: Discussionsupporting

confidence: 91%

Crosstalk of multi-omics reveals specific characteristics in active ulcerative colitis patients with depression and anxiety

Yuan¹,

Chen²,

Duan³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:Ulcerative colitis (UC) patients have a high incidence of mental disorders. The microbiota-gut-brain axis dysfunction is considered as one important pathogenesis of mental diseases. At present, little is known about how gut microbiota interact with the host in UC patients with depression and anxiety.Results: This prospective observational study enrolled 240 Chinese patients in two cohorts: the discovery cohort, including 69 active UC patients, 49 non-inflammatory bowel disease (IBD) depression and anxiety patients, and 62 healthy people, and the replication cohort of 60 active UC patients. About half of active UC patients showed symptoms of depression or anxiety. Through 16s rRNA sequencing, it was found that these UC patients accompanied with depression and anxiety had lower fecal microbial abundance with more Sellimonas , Eubacterium ventriosum group , Enterococcus , and Peptoclostridium , but less Prevotella_9 , Erysipelotrichaceae UCG_003 , Collinsella , and Dorea , compared with non-depressed/ anxious UC patients. Serum metabolome and proteome analysed using liquid chromatography/ mass spectrometry showed significantly increased glycochenodeoxycholate, stearoyllysophosphatidylcholine, and glyceryl stearates, while decreased 2'-deoxy-D-ribose and a set of immunoglobulin protein in the serum of UC patients with depression and anxiety. Through integration of multiple statistical analyses and multi-omics correlation analyses, we revealed a highly connected and comprehensive network, centring on Prevotella_9 and 1-stearoyl-sn-glycerol, composed of these bacteria, metabolites and proteins associated with UC-specific depression and anxiety.Conclusion: This study has identified a highly connected multi-omics network, composed of a set of gut microbiota, serum metabolites and proteins, specifically related to depression and anxiety in active UC. This network might influence host's mental state through mediating the effect of gut inflammation on synapse pruning in the central nervous system.

show abstract

Section: Discussionsupporting

confidence: 91%

Crosstalk of multi-omics reveals specific characteristics in active ulcerative colitis patients with depression and anxiety

Yuan¹,

Chen²,

Duan³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The Ruminococcaceae family and the genera belonging to this family have shown altered relative abundance in individuals diagnosed with several psychiatric diseases, i.e. autism, bipolar disorder, anxiety, depression, schizophrenia as well as ADHD [41][42][43][44]. Even though there is a lack of knowledge about the functional role of Ruminoccocace_UCG_004 genus and its effect on the host, the Ruminococcaceae family is well described.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

Dam¹,

Naaijen²,

Konstanti³

et al. 2020

Preprint

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Given the growing evidence of gut microbiota being involved in psychiatric (including neurodevelopmental) disorders, we aimed to identify differences in gut microbiota composition between participants with ADHD and controls and to investigate the role of the microbiota in inattention and hyperactivity/impulsivity. Fecal samples were collected from 107 participants (NADHD=42; Ncontrols=50; NsubthreholdADHD=15; range age: 13-29 years). The relative quantification of bacterial taxa was done using 16S ribosomal RNA gene amplicon sequencing. Beta-diversity revealed significant differences in bacterial composition between participants with ADHD and healthy controls, which was also significant for inattention, but showing a trend in case of hyperactivity/impulsivity only. Ten genera showed nominal differences (P < 0.05) between both groups, of which seven genera were tested for their association with ADHD symptom scores (adjusting for age, sex, body mass index, time delay between feces collection and symptoms assessment, medication use and family relatedness). Our results show that variation of a genus from the Ruminococcaceae family (Ruminococcaceae_UCG_004) is associated (after multiple testing correction) with inattention symptoms, and suggest a role of gut microbiota in ADHD pathophysiology.

show abstract

“…As determined by Beck's Depression Inventory cut‐off score of 18, the family of Enterobacteriaceae was more abundant in patients with clinically relevant depressive symptoms, while the family of Clostridiaceae and the genus Roseburia were more abundant in recovered BD patients. Specific bacterial clades were associated with inflammatory status, serum lipids, tryptophan level, oxidative stress, depressive symptoms, and metabolic syndrome, indicating a complex interactive network between host health and gut microbiome 45 . These findings suggested that specific bacteria species in the intestine were associated with different BD subtypes and severity of depression, and might affect host immune, metabolic and oxidative stress processes.…”

Section: Gut Microbiome and Bd In Human Studiesmentioning

confidence: 99%

Gut microbial clues to bipolar disorder: State‐of‐the‐art review of current findings and future directions

Lai

Jiang

Zhang

et al. 2020

Clinical & Translational Med

View full text Add to dashboard Cite

Trillions of microorganisms inhabiting in the human gut play an essential role in maintaining physical and mental health. The connections between gut microbiome and neuropsychiatric diseases have been recently identified. The pathogenesis of bipolar disorder, a spectrum of diseases manifesting with mood and energy fluctuations, also seems to be involved in the bidirectional modulation of the microbiome‐gut‐brain (MGB) axis. In this review, we briefly introduce the concept of MGB axis, and then focus on the previous findings in human studies associated with bipolar disorder. These studies provided preliminary evidences on the gut microbial alterations in bipolar disorder. Limitations in these studies and future directions in this research field, such as fecal microbiome transplantation and microbiome‐targeted therapy, were discussed. A research framework linking gut microbiome to determinants and health‐related outcomes in BD was also proposed. Better characterizing and understanding of gut microbial biosignatures in bipolar patients contribute to clarify the etiology of this intractable disease and pave the new way for treatment innovation.

show abstract

A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode

Cited by 164 publications

References 59 publications

Crosstalk of multi-omics reveals specific characteristics in active ulcerative colitis patients with depression and anxiety

Crosstalk of multi-omics reveals specific characteristics in active ulcerative colitis patients with depression and anxiety

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

Gut microbial clues to bipolar disorder: State‐of‐the‐art review of current findings and future directions

Contact Info

Product

Resources

About