A Statistical Approach to Optimize the Spray Drying of Starch Particles: Application to Dry Powder Coating

Bilancetti, Luca; Poncelet, Denis; Loisel, Catherine; Mazzitelli, Stefania; Nastruzzi, Claudio

doi:10.1208/s12249-010-9492-y

Cited by 23 publications

(33 citation statements)

References 11 publications

(15 reference statements)

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“…Furthermore, the feed of droplets may be dripping in the drying chamber . Hence, the percent of solid recovery was reduced significantly . Indeed, the powder recovery percent of 0% was obtained at a feed flow rate higher than 75 ml/min.…”

Section: Resultsmentioning

confidence: 65%

“…The nozzle pressure and droplet size and distribution are inversely proportional . Indeed, smaller size of generated droplets was obtained when higher kinetic energy was available for the liquid disintegration (atomization), due to the higher relative motion created between liquid and air …”

Section: Resultsmentioning

confidence: 99%

“…For example, in the coating process, the achievement of a reasonable shell formation around particles, the kind of selected polymers and physicochemical, microstructural, and dimensional properties such as solubility, morphology, porosity, and size of two primary particles of coating are critical parameters, because the size ratio of these particles depends on the cohesive forces between them. In this regard, spray drying is the preferred method to produce powders with controllable properties …”

Section: Introductionmentioning

confidence: 99%

“…Takeuchi et al, Bilancetti et al, and Esposito et al have produced different particles with specific properties by spray drying for several pharmaceutical applications and different targeted drug release…”

Section: Introductionmentioning

confidence: 99%

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Impact of operating conditions on a single droplet and spray drying of hydroxypropylated pea starch: Process performance and final powder properties

Gouaou

Shamaei

Koutchoukali

et al. 2018

Asia-Pacific J Chem Eng

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For an efficient production of spray‐dried fine powders having controllable properties (size, size distribution, and morphology), finding suitable operating conditions and an appropriate initial composition of the fluid material is important. For this purpose, a suspension device is employed to investigate the drying kinetics of a single droplet of hydroxypropylated pea starch (HPS). In the current work, the effect of the drying air temperature (80–160°C) and of the initial solid content of the agent (15–30%w/w) on the drying kinetics, shrinkage, and locking point of a single droplet was systematically investigated to acquire the optimal conditions required for producing HPS powder using a pilot‐scale spray dryer. In addition to the previously mentioned parameters, the atomization pressure effect (2–3 bars) on the spray‐drying process yield, thermal efficiency, and final powder properties were also considered. A laboratory‐scale X‐ray microtomograph and a camsizer‐XT were employed for the acquisition of three‐dimensional images and surface morphology of single dried particles and spray‐dried powder, respectively. Hollow particles were obtained in all single droplet experiments. The drying kinetic study results were supported by those obtained by the spray drying of HPS. An increased temperature of the drying air and the initial solid content of the solution results in higher powder recovery, lower residual moisture content, and larger particle size. Otherwise, the final particles are larger at a decreased atomization pressure. The optimized parameters for the high spray‐drying process yield (24.54%; 3 bars, 140°C, 25 wt%) and better powder homogeneity (span = 2.31; 3 bars, 140°C, 20 wt%) were defined. A mixture of particle morphologies was observed among the different final powders. A broken shell corresponding to rigid particles was obtained at a drying temperature of 140°C and an initial solid content of 25 wt%. A nonbroken particle refers to a pliable particle that corresponds to inflated and collapsed particles dried at high and low drying temperatures.

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Section: Resultsmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of operating conditions on a single droplet and spray drying of hydroxypropylated pea starch: Process performance and final powder properties

Gouaou

Shamaei

Koutchoukali

et al. 2018

Asia-Pacific J Chem Eng

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“…The temperature employed in spray-drying should avoid any thermal degradation of drying material. 24) When the inlet temperature was above 180°C, it substantially increased the outlet temperature to above the melting point of flurbiprofen (115°C), thus highest level of inlet temperature was selected as 180°C. Similarly, a feed rate of up to 15% could be used without condensation appearing in the drying chamber.…”

Section: Box-behnken Statistical Analysis and Model Fitting Of The Datamentioning

confidence: 99%

Statistical modeling, optimization and characterization of spray-dried solid self-microemulsifying drug delivery system using design of experiments

Marasini

Tran

Poudel

et al. 2013

CHEMICAL & PHARMACEUTICAL BULLETIN

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The present study systematically and simultaneously investigates the influence of process variables of spray-drying on the properties of solid self-microemulsifying drug delivery system (SmeddS) using design of experiment (DOE) and optimizes them in order to produce solid-SMEDDS satisfying pre-defined powder quality attributes. Flurbiprofen-loaded liquid-SMEDDS was dispersed in dextran and spray-dried. After preliminary screening, the independent factors selected according to three-factor, three-level Box-Behnken design were inlet temperature (X 1 ), feed rate (X 2 ) and carrier concentration (X 3 ). The responses used to compute the effects of independent factors were moisture content (Y 1 ), yield (Y 2 ), drug content (Y 3 ) and droplet size (Y 4 ) of the micro-emulsion. SMEDDS powder characteristics such as morphology, thermal behavior, crystallinity and flowability were also considered. Models were developed and model fitting analysis showed an adequate fit for all responses, indicating good predictability. Significant effects of processing parameters on powder characteristics were observed. The spray-drying process parameters were optimized as inlet temperature (134°C), feed rate (5%) and carrier concentration (0.6%) to produce solid-SMEDDS with acceptable moisture content (0.72±0.02%), yield (58.5±2.9%), drug content (70.1±2.7 mg/g) and droplet size (166.8±13.8 nm). Validation of the optimization process in five batches showed experimental value very close to the predicted one, ensuring the reproducibility of the developed models. Furthermore, optimized parameters resulted a highly crystalline flurbiprofen changed to an amorphous form. In conclusion, this study demonstrated the applicability of the DOE approach for optimizing the process parameters to manufacture solid-SMEDDS with desired quality attributes.Key words design of experiment; Box-Behnken design; optimization; self-microemulsifying drug delivery system; spray-drying Self-microemulsifying drug delivery system (SMEDDS) has been emphasized in recent years for its ability to improve the solubility and bioavailability of poorly water-soluble drugs. Conventionally, SMEDDS are prepared as liquid formulations that are either delivered in soft or hard gelatin capsules 1) However, a liquid form of SMEDDS has several potential drawbacks in manufacturing scale-up such as less stability due to the precipitation of active ingredients, especially at lower temperatures, interactions of formulation components with the capsule shells, and leakage from the capsules.2,3) In order to overcome these limitations, the liquid-based dispersion must be converted into a dry product. In addition, a solid form of SMEDDS formulation combines the advantages of enhanced solubility and bioavailability with a higher stability compared to its corresponding liquid formulation. 4) Solidification can be achieved by dispersion of liquid SMEDDS into a suitable inert solid carrier in an aqueous medium, followed by elimination of the water via several techniques such as spray-drying. Th...

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Optimization of the Spray Drying Process of the Esterified Plantain Starch by Response Surface Methodology

et al. 2019

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The response surface methodology, with a rotatable central composite design, is used in this study for optimizing spray drying process conditions to obtain a fine modified starch powder from “Dominico Hartón” plantains, which are chemically modified with 2‐octenyl‐succinic anhydride. A pilot‐scale spray dryer is used, and the following process factors are evaluated: (A) air inlet temperature (136–154 °C), (B) air outlet temperature (69–81 °C), and (C) rotational atomizer speed (17666–34333 rpm). The response variables are yield, moisture content, and functional properties such as water absorption index (WAI); water solubility index (WSI), swelling power (SP) and degree of substitution (DS). The factors B and C significantly influence the functional properties. The following are the optimal conditions from the process: factor (A), 150 °C; factor (B), 80 °C; and factor (C), 34 858 rpm, with the desirability of 56.7%. Under these optimal conditions, chemically modified plantain starch with desirable quality properties of low moisture content, water activity, and solubility index and high process yield, water absorption index, swelling power, and degree of substitution could be produced.

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A Statistical Approach to Optimize the Spray Drying of Starch Particles: Application to Dry Powder Coating

Cited by 23 publications

References 11 publications

Impact of operating conditions on a single droplet and spray drying of hydroxypropylated pea starch: Process performance and final powder properties

Impact of operating conditions on a single droplet and spray drying of hydroxypropylated pea starch: Process performance and final powder properties

Statistical modeling, optimization and characterization of spray-dried solid self-microemulsifying drug delivery system using design of experiments

Optimization of the Spray Drying Process of the Esterified Plantain Starch by Response Surface Methodology

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