A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes

Yu, Biao; Liu, Juanjuan; Cheng, Jing; Zhang, Lei; Chen, Song; Tian, Xiaofei; Yang, Fan; Lv, Yue; Zhang, Xin

doi:10.1016/j.xinn.2021.100077

Cited by 26 publications

(35 citation statements)

References 50 publications

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“…[7][8][9][10] In contrast to tools such as high pressure and high temperature that require critical experiment conditions, a commercial permanent magnet is enough to influence many chemical reactions. [11,12] For example, an extremely low magnetic field of 55 mT (600 times the magnetic field of earth) can accelerate the catalytic ATP synthesis by 50%. [13] Recently, there has been growing research interest regarding the effects of magnetic interactions on the rate of hydrogen-energy-related reactions such as in water splitting and fuel cells (Figure 1a).…”

Section: Introductionmentioning

confidence: 99%

Magnetocatalysis: The Interplay between the Magnetic Field and Electrocatalysis

Yang

Manna

et al. 2021

CCS Chem

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Magnetic fields are known as clean, economic, and effective tools to modify band and magnetic structures of materials. When coupled with catalytic processes such as hydrogen evolution reaction (HER), it has the potential to control the catalytic efficiencies. However, the underlying mechanism of magneto-catalysis is poorly studied and little understood. Here, we studied the magnetic response of a series of materials as HER catalysts, specifically, ferromagnetic Co 2 VGa, Co 2 MnGa and Ni, ferrimagnetic Mn 2 CoGa, and paramagnetic Pt.We found all the Heusler compounds exhibit impressively high intrinsic activities. Most importantly, the presence of a magnetic field could change the HER efficiencies significantly, regardless of the magnetic states of the catalysts. We observed boosting HER kinetics for ferromagnetic Ni and paramagnetic Pt, and a decrease of efficiency for ferro/ferrimagnetic Heusler alloys. Our calculations suggest that the binding energy between the reaction intermediate and the catalyst can be tailored effectively by controlling the number of transferred electrons. The findings highlight the vital role of magnetic fields in tailoring heterogeneous catalytic reactions that involving adsorption of reactants.

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Section: Introductionmentioning

confidence: 99%

Magnetocatalysis: The Interplay between the Magnetic Field and Electrocatalysis

Yang

Manna

et al. 2021

CCS Chem

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“…Additionally, the reductions of ROS levels were found in human peripheral blood neutrophils [ 33 ] and bronchial epithelial cells [ 34 ] when exposed to 60 mT and 389 mT SMFs, respectively. In our previous study, exposure to SMFs of 0.1 T~0.5 T could reduce ROS levels and improve gut microbes, which improved T2D mice [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, Van Huizen et al found that weak SMFs could alter stem cell proliferation and differentiation through regulating ROS levels and the downstream heat shock protein 70 [ 16 ]. Recently, two papers both show that SMF or SMF combined with electric field could regulate the redox process and ROS levels, which are essential for their role in alleviating mouse type 2 diabetes [ 17 , 18 ]. However, the effect of SMF on cancer metastasis is unclear and whether SMF could regulate ROS levels to interfere with cancer metastasis is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS‐Mediated Oxidative Stress

Chen

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Metastasis is the leading cause of cancer patient death, which is closely correlated with reactive oxygen species (ROS) levels. It is well known that the effects of ROS on tumors are diverse, depending on ROS concentration and cell type. We found that ovarian cancer cells have significantly lower levels of ROS than normal ovarian cells. Moreover, increased ROS levels in ovarian cancer cells can substantially inhibit their migration and invasion ability. Furthermore, the results show that moderate static magnetic field (SMF) can inhibit ovarian cancer cell migration, invasion, and stemness in a ROS-dependent manner. RNA sequencing results confirm that SMFs increased the oxidative stress level and reduced the stemness of ovarian cancer cells. Consistently, the expressions of stemness-related genes were significantly decreased, including hyaluronan receptor (CD44), SRY-box transcription factor 2 (Sox2), and cell myc proto-oncogene protein (C-myc). Furthermore, moderate SMFs provided by a superconducting magnet and permanent magnet have good biosafety and can both inhibit ovarian cancer metastasis in mice. Therefore, our study demonstrates the effects of SMFs on oxidative stress and metastasis in the ovarian cancer cells, which reveals the potential of applying SMF as a physical method in cancer therapy in the future.

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“…These studies reveal that using SMFs to improve wound healing in diabetes patients seems to have a lot of potential in the future. Moreover, previous studies also show that 100 mT moderate SMF alone or 3 mT moderate SMF combined with electric field could reduce ROS level to reduce blood glucose and significantly alleviate type 2 diabetes (T2D) complications, including fatty liver and renal defects [31,33]. However, whether we can use a specific SMF device to improve diabetic wound healing as well as alleviate other diabetic complications simultaneously is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications

Feng

Chen

et al. 2022

Cells

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Although some studies have shown that some static magnetic fields (SMFs) can promote wound healing in diabetic mice, it is not clear whether the other diabetes complications, such as liver disease and diabetic nephropathy, can also be alleviated. Here, we constructed two simple magnetic plates using neodymium permanent magnets to examine the comprehensive effects of moderate SMFs on genetically obese leptin receptor-deficient db/db diabetic mice. We found that although the blood glucose was not obviously reduced by these two SMF settings, both of the glycated serum protein (GSP) and malondialdehyde (MDA) levels were significantly decreased (Cohen’s d = 2.57–3.04). Moreover, the wound healing, liver lipid accumulation, and renal defects were all significantly improved by SMF treatment (Cohen’s d = 0.91–2.05). Wound tissue examination showed obvious nuclear factor erythroid 2-related factor 2 (NRF2) level decrease (Cohen’s d = 2.49–5.40) and Ki-67 level increase (Cohen’s d = 2.30–3.40), indicating decreased oxidative stress and increased cell proliferation. In vitro cellular studies with fibroblast NIH3T3 cells showed that SMFs could reduce high glucose-induced NRF2 nucleus translocation (Cohen’s d = 0.87–1.15) and cellular reactive oxygen species (ROS) elevation (Cohen’s d = 0.92), indicating decreased oxidative stress. Consequently, high glucose-induced impairments in cell vitality, proliferation, and migration were all improved by SMF treatment. Therefore, our results demonstrate that these simple SMF devices could effectively reduce oxidative stress in diabetic mice and may provide a cost-effective physical therapy strategy to alleviate multiple diabetic complications in the future.

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A Static Magnetic Field Improves Iron Metabolism and Prevents High-Fat-Diet/Streptozocin-Induced Diabetes

Cited by 26 publications

References 50 publications

Magnetocatalysis: The Interplay between the Magnetic Field and Electrocatalysis

Magnetocatalysis: The Interplay between the Magnetic Field and Electrocatalysis

Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS‐Mediated Oxidative Stress

Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications

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