A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system

Assefi, Marjan; Ataeinaeini, Mehrnaz; Nazari, Ahmad; Gholipour, Arsalan; Vertiz-Osores, Jacinto Joaquin; Vásquez, Kriss Melody Calla; Al-Naqeeb, Bashar Zuhair Talib; Jassim, Kadhim Hussein; Kalajahi, Hesam Ghafouri; Yasamineh, Saman; Dadashpour, Mehdi

doi:10.1016/j.jddst.2023.104623

Cited by 14 publications

(3 citation statements)

References 157 publications

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“…These studies should integrate immunoinformatic tools with in vivo and in vitro research to investigate the virus's molecular structure, pathophysiology, immunological properties, and other related aspects. The aforementioned situations and characteristics contribute to the limitations associated with producing vaccines for CCHFV and provide possible directions for future research in this field [233,223].…”

Section: Nucleic Acid Vaccinesmentioning

confidence: 99%

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Muzammil,

Rayyani,

Abbas Sahib

et al. 2024

Biol Proced Online

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Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no specific clinical symptoms, mild to severe clinical symptoms, or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), and reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, and cheap technology, including biosensors, must be designed and developed to detect CCHFV. The goal of this article is to offer an overview of modern laboratory tests available as well as other innovative detection methods such as biosensors for CCHFV, as well as the benefits and limits of the assays. Furthermore, confirmed cases of CCHF are managed with symptomatic assistance and general supportive care. This study examined the various treatment modalities, as well as their respective limitations and developments, including immunotherapy and antivirals. Recent biotechnology advancements and the availability of suitable animal models have accelerated the development of CCHF vaccines by a substantial margin. We examined a range of potential vaccines for CCHF in this research, comprising nucleic acid, viral particles, inactivated, and multi-epitope vaccines, as well as the present obstacles and developments in this field. Thus, the purpose of this review is to present a comprehensive summary of the endeavors dedicated to advancing various diagnostic, therapeutic, and preventive strategies for CCHF infection in anticipation of forthcoming hazards. Graphical Abstract

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Section: Nucleic Acid Vaccinesmentioning

confidence: 99%

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Muzammil,

Rayyani,

Abbas Sahib

et al. 2024

Biol Proced Online

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“…Additionally, the use of a solid lipid as a matrix enables the protection of thermolabile active substances [5][6][7]. Among the ways of application of colloidal systems based on solid lipids extensively documented in the literature are cosmetic [5,8,9], food [4,6,10], and, above all, in the pharmaceutical industry (i.e., drug delivery) [7,11,12]. In recent years, lipid formulations have enabled the effective encapsulation of active substances successfully delivered intravenously [13][14][15], orally [16][17][18], transdermally [19][20][21], and also directly into the eye [22][23][24] or nose [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Natural-Origin Betaine Surfactants as Promising Components for the Stabilization of Lipid Carriers

Pucek-Kaczmarek,

Celary,

Bazylińska

2024

IJMS

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In the present work, we demonstrate studies involving the influence of the formulation composition on the physicochemical properties of nanocarriers: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). Novel lipid-origin platforms were prepared using two “green” betaine-based surfactants, cocamidopropyl betaine (ROKAmina K30) and coco betaine (ROKAmina K30B), in combination with three different solid lipids, cetyl palmitate (CRODAMOL CP), trimyristin (Dynasan 114), and tristearin (Dynasan 118). Extensive optimization studies included the selection of the most appropriate lipid and surfactant concentration for effective SLN and NLC stabilization. The control parameters involving the hydrodynamic diameters of the obtained nanocarriers along with the size distribution (polydispersity index) were determined by dynamic light scattering (DLS), while shape and morphology were evaluated by atomic force microscopy (AFM) and transmission electron microscopy (TEM). Electrophoretic light scattering (ELS) and turbidimetric method (backscattering profiles) were used to assess colloidal stability. The studied results revealed that both betaine-stabilized SLN and NLC formulations containing CRODAMOL CP as lipid matrix are the most monodisperse and colloidally stable regardless of the other components and their concentrations used, indicating them as the most promising candidates for drug delivery nanosystems with a diverse range of potential uses.

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“…Among the various available nanoencapsulation systems, solid lipid nanoparticles (SLNPs) present a promising platform for drug delivery [ 22 , 23 , 24 , 25 ]. They enhance the solubility and bioavailability of hydrophobic drugs, provide sustained release for prolonged therapeutic effects, and improve chemical stability [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Solid Lipid Nanoparticles Enhancing the Leishmanicidal Activity of Delamanid

Santamaría-Aguirre,

Jacho,

Méndez

et al. 2023

Pharmaceutics

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Leishmaniasis, a zoonotic parasitic disease transmitted by infected sandflies, impacts nearly 1 million people yearly and is endemic in many countries across Asia, Africa, the Americas, and the Mediterranean; despite this, it remains a neglected disease with limited effective treatments, particularly in impoverished communities with limited access to healthcare. This study aims to repurpose approved drugs for an affordable leishmaniasis treatment. After the screening of potential drug candidates by reviewing databases and utilizing molecular docking analysis, delamanid was chosen to be incorporated into solid lipid nanoparticles (SLNPs). Both in cellulo and in vivo tests confirmed the successful payload release within macrophages and through the epidermis following topical application on murine skin. The evaluation of macrophages infected with L. infantum amastigotes showed that the encapsulated delamanid exhibited greater leishmanicidal activity compared with the free drug. The process of encapsulating delamanid in SLNPs, as demonstrated in this study, places a strong emphasis on employing minimal technology, ensuring energy efficiency, cost-effectiveness, and reproducibility. It enables consistent, low-cost production of nanomedicines, even on a small scale, offering a promising step toward more accessible and effective leishmaniasis treatments.

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A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system

Cited by 14 publications

References 157 publications

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Natural-Origin Betaine Surfactants as Promising Components for the Stabilization of Lipid Carriers

Solid Lipid Nanoparticles Enhancing the Leishmanicidal Activity of Delamanid

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