A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy
Zenghui Li,
Yuqing Feng,
Hong Han
et al.
Abstract:METTL3, a primary methyltransferase catalyzing RNA m6A modification, has been identified as an oncogene in several cancer types and thus nominated as a potentially effective target for therapeutic inhibition, although current options using this strategy are limited. In this study, we targeted protein-protein interactions at the METTL3-METTL14 binding interface to inhibit complex formation and subsequent catalysis of RNA m6A modification. Among candidate peptides, RM3 exhibited the highest anti-cancer potency, … Show more
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