A standardized social preference protocol for measuring social deficits in mouse models of autism

Rein, Benjamin; Ma, Kaijie; Yan, Zhen

doi:10.1038/s41596-020-0382-9

Cited by 119 publications

(93 citation statements)

References 63 publications

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“…In our study, we did not detect any differences in social interaction using a modified 3-chamber social task, and even if some studies have showed an altered social interaction (Pen ˜agarikano et al, 2011(Pen ˜agarikano et al, , 2015Selimbeyoglu et al, 2017), others were not able to detect it (Scott et al, 2019). Additional studies combining different social task protocols to precisely detect which component of the social interaction is impaired in Cntnap2 KO mice, and at what precise stage of development, are warranted (as suggested in Rein et al, 2020). An additional caveat is that alterations in interneuronmediated inhibition for Cntnap2 KO mice were evaluated at a single adult epoch in development, and it is possible that these deficits could lead to additional homeostatic alterations in circuit function (Turrigiano, 2011;Howard et al, 2014;Wu et al, 2020).…”

Section: Discussioncontrasting

confidence: 51%

Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder

et al. 2021

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Section: Discussioncontrasting

confidence: 51%

Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder

et al. 2021

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“…The three-chamber sociability test assesses anxiety and depression in the form of general sociability in rodent models of CNS disorders (Nadler et al, 2004;Kaidanovich-Beilin et al, 2011;Johnson et al, 2013;Lopatina et al, 2014;Rein et al, 2020;Becker et al, 2021). Because rodents normally prefer to spend more time with another rodent (sociability), the threechamber test can help identify rodents with deficits in sociability.…”

Section: Discussionmentioning

confidence: 99%

Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma

Dickerson

Murphy

Urban

et al. 2021

Front. Behav. Neurosci.

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Long-term neuropsychiatric impairments have become a growing concern following blast-related traumatic brain injury (bTBI) in active military personnel and Veterans. Neuropsychiatric impairments such as anxiety and depression are common comorbidities that Veterans report months, even years following injury. To understand these chronic behavioral outcomes following blast injury, there is a need to study the link between anxiety, depression, and neuropathology. The hippocampus and motor cortex (MC) have been regions of interest when studying cognitive deficits following blast exposure, but clinical studies of mood disorders such as major depressive disorder (MDD) report that these two regions also play a role in the manifestation of anxiety and depression. With anxiety and depression being common long-term outcomes following bTBI, it is imperative to study how chronic pathological changes within the hippocampus and/or MC due to blast contribute to the development of these psychiatric impairments. In this study, we exposed male rats to a repeated blast overpressure (~17 psi) and evaluated the chronic behavioral and pathological effects on the hippocampus and MC. Results demonstrated that the repeated blast exposure led to depression-like behaviors 36 weeks following injury, and anxiety-like behaviors 2-, and 52-weeks following injury. These behaviors were also correlated with astrocyte pathology (glial-fibrillary acid protein, GFAP) and dendritic alterations (Microtubule-Associated Proteins, MAP2) within the hippocampus and MC regions at 52 weeks. Overall, these findings support the premise that chronic glial pathological changes within the brain contribute to neuropsychiatric impairments following blast exposure.

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“…Repeated exposure to social defeat stress in rodents causes behavioral abnormalities marked by social avoidance, consummatory behaviors, and anxiety‐like phenotypes [ 53 ]. While one‐chamber SIT is widely used to classify the response to the CSDS as ‘susceptible’ and ‘resilient’ subpopulation [ 4 , 54 ], three‐chamber social approach test has advantages for the assessment of social behaviors [ 55 , 56 , 57 , 58 , 59 ]. Nonetheless, to our knowledge, there is no report differentiating ‘susceptible’ and ‘resilient’ behavioral phenotypes induced by CSDS using three‐chamber social approach test.…”

Section: Resultsmentioning

confidence: 99%

“…We utilized the three-chamber social approach test to differentiate 'susceptible' and 'resilient' mice as the response to CSDS. Compared with one-chamber social interaction test that classically used for evaluating stress susceptibility, three-chamber social approach test has advantages for the assessment of social behaviors [54][55][56][57][58]. While the social interaction is evaluated by encountering time of the test C57 mouse to CD-1 mouse in one-chamber social interaction test [53], three-chamber social approach test assesses the preference of "novel target same strain mouse vs. inanimate object" [43,56].…”

Section: Accepted Articlementioning

confidence: 99%

Alterations in circulating extracellular vesicles underlie social stress‐induced behaviors in mice

et al. 2021

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Chronic stress induces peripheral and intracerebral immune changes and inflammation, contributing to neuropathology and behavioral abnormalities relevant to psychiatric disorders such as depression.Although the pathological implication of many peripheral factors such as pro-inflammatory cytokines, hormones, and macrophages has been demonstrated, the roles of circulating extracellular vesicles (EVs) for chronic stress mechanisms remain poorly investigated. Here we report that chronic social defeat stress (CSDS)-induced social avoidance phenotype, assessed by a previously untested threechamber social approach test, can be distinguished by multiple pro-inflammatory cytokines and EVassociated molecular signatures in the blood. We found that the expression patterns of miRNAs distinguished the CSDS-susceptible mice from the CSDS-resilient mice. Social avoidance behavior scores were also estimated with good accuracy by the expression patterns of multiple EV-associated miRNAs. We also demonstrated that EVs enriched from the CSDS-susceptible mouse sera upregulated the production of pro-inflammatory cytokines in the LPS-stimulated microglia-like cell lines. Our results indicate the role of circulating EVs and associated miRNAs in CSDS susceptibility, which may be related to pro-inflammatory mechanisms underlying stress-induced neurobehavioral outcomes.

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A standardized social preference protocol for measuring social deficits in mouse models of autism

Cited by 119 publications

References 63 publications

Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder

Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder

Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced Neurotrauma

Alterations in circulating extracellular vesicles underlie social stress‐induced behaviors in mice

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