A Standard Microcinematographic Apparatus

Rosenberger, Heinz

doi:10.1126/science.69.1800.672

Cited by 6 publications

(2 citation statements)

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“…And in 1929, Heinz Rosenberger designed and patented a microcinematographic apparatus for researchers to use as an automatic recording instrument. Although Rozenberger's system remarkably included most of the features in today's instruments, it is not clear if this design penetrated the market, as it appears he intended 10. By the 1950s, a variety of time‐lapse approaches or filming were being used to study live cell behavior, such as UV time‐lapsed images to follow mitosis in newt cells and film microscopy to study cell death in the presence of irradiation 1, 4.…”

Section: Introductionmentioning

confidence: 99%

Automated live cell imaging systems reveal dynamic cell behavior

Chirieleison

Bissell

Scelfo

et al. 2011

Biotechnology Progress

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Automated time-lapsed microscopy provides unique research opportunities to visualize cells and subcellular components in experiments with time-dependent parameters. As accessibility to these systems is increasing, we review here their use in cell science with a focus on stem cell research. Although the use of time-lapsed imaging to answer biological questions dates back nearly 150 years, only recently have the use of an environmentally controlled chamber and robotic stage controllers allowed for high-throughput continuous imaging over long periods at the cell and subcellular levels. Numerous automated imaging systems are now available from both companies that specialize in live cell imaging and from major microscope manufacturers. We discuss the key components of robots used for time-lapsed live microscopic imaging, and the unique data that can be obtained from image analysis. We show how automated features enhance experimentation by providing examples of uniquely quantified proliferation and migration live cell imaging data. In addition to providing an efficient system that drastically reduces man-hours and consumes fewer laboratory resources, this technology greatly enhances cell science by providing a unique dataset of temporal changes in cell activity.

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Section: Introductionmentioning

confidence: 99%

Automated live cell imaging systems reveal dynamic cell behavior

Chirieleison

Bissell

Scelfo

et al. 2011

Biotechnology Progress

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“…Alexis Carrel, for example, an early pioneer of mammalian cell culture, used his cinematograph to study the locomotion of fibroblasts and macrophages (Carrel and Ebeling, 1926). Subsequently, Carrel's technical assistant, Heinz Rosenberger (who actually produced Carrel's movies for publication) published a methods article in Science on the use of the microcinematographic apparatus, apparently trying to convince investigators ''who have not yet realized the great possibilities of the motion-picture camera in research laboratories'' (Rosenberger, 1929b). However, scientists did not need much convincing, as movie-making in the laboratory quickly moved beyond cell culture.…”

Section: Cinemicroscopy Before Cell Culturementioning

confidence: 99%

Cells on film – the past and future of cinemicroscopy

Stramer

Dunn

2015

Journal of Cell Science

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Movie making is now a ubiquitous experimental tool that biologists use alongside more traditional techniques such as molecular biology and biochemistry. It is no longer just cell biologists, but scientists from many other disciplines, such as immunology and neuroscience, that utilise movies to dissect their processes of interest. When did filming become such a standard laboratory technique? Who developed the use of the movie as an experimental tool? The Wellcome Library has recently restored and digitized a number of original 16-mm films from two pioneering cinemicroscopists, Ronald Canti and Michael Abercrombie, which are now freely available to the scientific community. In light of these films, this Essay will give a brief history of the early cinemicroscopists and discuss what is driving the use of movies in the laboratory today.

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A moving‐picture apparatus for microscopic work

Patten

Krammer

1932

Anat. Rec.

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A Standard Microcinematographic Apparatus

Cited by 6 publications

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Automated live cell imaging systems reveal dynamic cell behavior

Automated live cell imaging systems reveal dynamic cell behavior

Cells on film – the past and future of cinemicroscopy

A moving‐picture apparatus for microscopic work

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