A Staging System for Assessing Severity of Disease and Response to Therapy in Recurrent Respiratory Papillomatosis

Derkay, Craig S.; Malis, David J.; Zalzal, George H.; Wiatrak, Brian J.; Kashima, Haskins K.; Coltrera, Marc D.

doi:10.1097/00005537-199806000-00026

Cited by 197 publications

(149 citation statements)

References 3 publications

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“…Once the patient was admitted to the ORLS, a direct laryngoscopy showed papillomatous lesions in the vocal cords, confirming the diagnosis of laryngeal papillomatosis with a biopsy after a first surgery to remove the papillomas. The Derkay Score system was used to evaluate the severity of papillomatosis 13 , which indicated a score of 21, which coincided with a moderate clinical picture. Because papillomatous lesions and dysphonia were recurrent, the child underwent five surgical interventions in total, all of them for therapeutic purposes and always obtaining a sample for biopsy.…”

Section: Clinical Casementioning

confidence: 99%

Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

Benavente

Contreras

Perferi

et al. 2017

Rev. chil. pediatr.

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Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV. Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected. The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas. The Derkay classification system was used to assess the severity of papillomatosis. Biopsy genotyping was performed by demonstrating HPV-6. Later, HLAD-QA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing. Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.

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Section: Clinical Casementioning

confidence: 99%

Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

Benavente

Contreras

Perferi

et al. 2017

Rev. chil. pediatr.

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“…Several attempts have been made to distinguish aggressive from nonaggressive RRP. A widely used measure is the score by Derkay et al, 13 in which airway subsites are individually scored for RRP disease extent to yield a composite score. Anatomic scores exceeding 20 are considered to represent high risk for aggressive RRP requiring frequent surgical debridement.…”

Section: Commentmentioning

confidence: 99%

“…Anatomic scores exceeding 20 are considered to represent high risk for aggressive RRP requiring frequent surgical debridement. 13,14 Potential criticisms of the scoring system by Derkay et al include the somewhat cumbersome nature of individually scoring multiple different anatomical subsites, making this scoring system less applicable to retrospective studies. Another method of defining aggressive RRP used the total number of surgical procedures (with Ͼ40 lifetime operations representing aggressive RRP).…”

Section: Commentmentioning

confidence: 99%

Association of Asthma With Clinically Aggressive Recurrent Respiratory Papillomatosis

Robb¹,

Weinberger²,

Perakis³

et al. 2011

Arch Otolaryngol Head Neck Surg

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“…Se caracteriza por la aparición de crecimientos papilomatosos de aspecto similar al de las verrugas. Estos papilomas pueden causar una obstrucción respiratoria potencialmente mortal o/y cambios en la voz (1,2) . Es una enfermedad potencialmente devastadora, con una morbilidad significativa.…”

Section: Introductionunclassified

Papilomatosis respiratoria recurrente: análisis del impacto económico en el tratamiento quirúrgico

et al. 2017

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RESUMENObjetivo: Evaluar el impacto económico que genera el tratamiento quirúrgico de la papilomatosis respiratoria recurrente en el tercer nivel de atención. La papilomatosis respiratoria recurrente es una entidad prevalente. El impacto económico que genera se encuentra principalmente en la necesidad de las repetidas intervenciones quirúrgicas que requiere a lo largo de su evolución, además de la morbilidad que ocasiona esta en el paciente. Materiales y métodos: Este estudio se realizó en el Hospital de Especialidades N° 2, Centro Médico Nacional del Noroeste, IMSS. Diseño retrospectivo, observacional, trasversal. Muestreo no probabilístico por serie consecutiva de casos. En la descripción general del estudio, se revisaron los expedientes clínicos de los pacientes con diagnóstico de papilomatosis respiratoria recurrente atendidos en el servicio de esta institución de enero de 2010 a enero de 2012. Se tomaron datos como la edad, sexo, manejo quirúrgico y/o terapia coadyuvante, y costo generado por su atención quirúrgica exclusivamente. Resultados: De un total de 103 expedientes revisados, solo 39 se encontraron completos y cumplieron con los criterios de inclusión: 16 (41%) eran de sexo femenino y 23 (59%), de sexo masculino. Se encontraron 27 casos (69%) juveniles y 12 (30.8%) adultos. Solo 19 casos (48.7%) recibieron terapia coadyuvante. En 15 casos (38.5%) se practicó traqueotomía. El costo directo por intervención quirúrgica de resecciones fue de $322,943.92 (22,190 USD) en el grupo juvenil y de $55,225.33 (3,790 USD) en el grupo adulto. Conclusiones: El tratamiento quirúrgico de la papilomatosis respiratoria recurrente representa una carga financiera y una gran morbilidad tanto para las instituciones de salud como para la familia.Palabras clave: Papilomatosis respiratoria recurrente; tratamiento; costo (Fuente: DeSC BIREME). Recurrent respiratory papillomatosis: analysis of the economic impact generated by surgical treatment ABSTRACTObjective: To evaluate the economic impact generated by surgical treatment of recurrent respiratory papillomatosis in the tertiary care level. Recurrent respiratory papillomatosis is a prevalent entity. The economic impact it generates is mainly due to the need for repeated surgical interventions throughout its progression, in addition to the morbidity it causes to the patient. Materials and methods: This retrospective, observational, cross-sectional study was carried out at the Specialty Hospital No. 2, National Medical Center of the Northwest, Mexican Social Security Institute (IMSS), using a non-probability sampling by consecutive case series. In the general description of the study, clinical records of patients diagnosed with recurrent respiratory papillomatosis treated at this institution from January 2010 to January 2012 were reviewed. Data such as age, gender, surgical management and/or adjuvant therapy, and cost generated by exclusive surgical care, were collected. Results: Out of a total of 103 reviewed files, only 39 were complete and met the inclusion criteria: 16 (4...

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A Staging System for Assessing Severity of Disease and Response to Therapy in Recurrent Respiratory Papillomatosis

Cited by 197 publications

References 3 publications

Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

Association of Asthma With Clinically Aggressive Recurrent Respiratory Papillomatosis

Papilomatosis respiratoria recurrente: análisis del impacto económico en el tratamiento quirúrgico

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