A Stage-Restricted Secretory System in the Submandibular Gland of the Neonatal Rat

Ball, William D.; Nelson, Norma J.

doi:10.1111/j.1432-0436.1978.tb00957.x

Cited by 19 publications

(14 citation statements)

References 29 publications

(4 reference statements)

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“…The RNase measurable at four days post partum appears not to be a secreted protein, since its release is not effected by isoproterenol under conditions that do result in amylase secretion (Ball and Nelson, 1978a). Amylase has also been localized in secretory granules two days after birth (Tanaka et al, 1981).…”

Section: Activities During Developmentmentioning

confidence: 99%

“…This increase was found to parallel the ingrowth of sympathetic nerve fibers during this time period, suggesting the stimulation of receptor production by the nerves (Bottaro and Cutler, 1984;Cutler et al, 1985). In vitro, there is isoproterenol-stimulated release of amylase and Bi-immunoreactive proteins (Bi-IP, see below) from the four-day submandibular gland (Ball and Nelson, 1978a;Ball and Redman, 1984), and of Bi-IP from the sublingual gland at five days (Ball et al, 1988a).…”

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

“…Some laboratories have shown the parotid to be refractory to 3-adrenergic stimulation of both adenylate cyclase and protein secretion prior to two weeks post partum (Grand et al, 1975;Grand and Schay, 1978;Ludford and Talamo, 1983). On the other hand, under somewhat different conditions of secretory stimulation, isoproterenol markedly stimulates secretion of amylase by the four-day parotid (Ball and Nelson, 1978a), and of Bi-IP by the five-day parotid (Ball et al, 1988a Since the early studies by Grobstein (1953Grobstein ( , 1967, the submandibular gland has been considered to be the classic example of mesenchymal specificity in embryonic tissue induction. However, with ensuing refinements in culture conditions and cell-specific marker detection, mesenchymal specificity now appears to be limited to its ability to influence the pattern of epithelial branching.…”

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

“…The first observable events in the cellular differentiation of the exocrine cells of submandibular glands begin within a few days following the onset of the morphogenesis described above. This differentiation is of exocrine cells which have been shown in rats to acquire a transient secretory system, well-differentiated but of unknown functional significance (Ball and Nelson, 1978a). The secretory cells are of five distinct types, based on the ultrastructural characteristics of their secretion granules (Cutler and Chaudry, 1974).…”

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

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Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

177

171

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The major salivary glands of mammals are represented by three pairs of organs that cooperate functionally to produce saliva for the oral cavity. While each type of gland produces a signature secretion that complements the secretions from the other glands, there is also redundancy as evidenced by secretion of functionally similar and, in some cases, identical products in the three glands. This, along with their common late initiation of development, in fetal terms, their similarities in developmental pattern, and their proximate sites of origin, suggests that a common regulatory cascade may have been shared until shortly before the onset of overt gland development. Furthermore, occasional ectopic differentiation of individual mature secretory cells in the wrong" gland suggests that control mechanisms responsible for the distinctive cellular composition of each gland also share many common steps, with only minor differences providing the impetus for diversification. To begin to address this area, we examine here the origins of the salivary glands by reviewing the expression patterns of several genes with known morphogenetic potential that may be involved based on developmental timing and location. The possibility that factors leading to determination of the sites of mammalian salivary gland development might be homologous to the regulatory cascade leading to salivarv gland formation in Drosophila is also evaluated. In a subsequent section, cellular phenotypes of neonatal and adult glands are compared and evaluated for insights into the mechanisms and lineages leading to cellular diversification. Finally, the phenomena of proliferation, repair, and regeneration in adult salivary glands are reviewed, with emphasis on the extent to which the cellular diversity is reversible and which cell type other than stem cells has the ability to redifferentiate into other cell types.

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Section: Activities During Developmentmentioning

confidence: 99%

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

See 2 more Smart Citations

Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

177

171

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“…These contain two distinct types of secretory cells, called Type I or terminal tubule cells and Type 111 or proacinar cells (Ball and Redman, 1984;Cutler and Chaudhry, 1974;Barka, 1973,1974). Type I cells secrete an 89 KD protein that we call protein SMG-C, whereas Type 111 cells secrete several members of a protein family called the B1-immunoreactive proteins; these include SMG-A (23.5 KD), -B1 (26 KD), and -B2 (27.5 KD), all of which are reactive with polyclonal antibodies to B1 (Ball et al, 1988a.b;Ball and Redman, 1984;Ball and Nelson, 1978). Still another secretory protein, Protein D (175 KD), is found in both perinatal cell types Ball and Redman, 1984).…”

Section: Introductionmentioning

confidence: 97%

Persistence of a perinatal cellular phenotype in submandibular glands of adult rat.

Man

Ball²,

Culp³

et al. 1995

J Histochem Cytochem.

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In the perinatal submandibular gland (SMG) of the rat, Type I cells secrete protein C (89 KD) and Type III cells secrete B1-immunoreactive proteins (20-30 KD); both cell types secrete protein D (175 KD). After the disappearance of both perinatal cell types from the maturing acini, only cells of the intercalated ducts (ID) show strong reactivity for the perinatal antigens. In adult ID, light and electron microscopic immunocytochemical analysis showed that most cells had either C or B1 reactivity, a few had either C and D or B1 and D reactivities, and some cells were unreactive for all of the perinatal proteins. Occasional clusters of "adult" acini, however, were strongly positive for B1 and for D, and these clusters were negative for a typical adult acinar marker, the glutamine/glutamic acid-rich proteins (GRP). Also seen in some preparations were a few anomalous acini with the histological appearance of sublingual (SLG) acini. These were negative for the perinatal and adult submandibular gland marker proteins but reactive with an antibody against SLG mucin. We suggest that the B1-positive acini in the adult SMG consist of newly differentiated replacement cells that have arisen from the ID, and that the anomalous mucous acini are, phenotypically, SLG acini that have differentiated within the SMG parenchyma.

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Cytodifferentiation of secretory cells in the sublingual gland of the prenatal rat: A histological, histochemical and ultrastructura study

Redman

Ball

1978

Am. J. Anat.

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Sublingual and submandibular glands were prepared for light and electron microscopy, and for histochemical staining with periodic acid-Schiff (PAS), Alcian Blue (AB) or both (AB-PAS). Between 15 and 17 days postconception, the sublingual gland undergoes active morphogenesis from a single, solid bud into a branched glandular tree. At 18 days the first overt signs of secretory differentiation appear in the formation of cells with three kinds of secretion granules; that is, electron-dense serous granules, empty-looking mucous granules with fine thread-like substructures, and granules which have the general appearance of mucous granules but also contain an internal, electron-dense core ("mixed" granules). During the period from 18 to 20 days, all three types of granulated cells increase in number, with mucous cells predominating, and they all border directly on the acinar lumina, in seemingly random combinations in different acini. This diversity is reflected in the histochemical staining, since most acini and cells are both PAS-and AB-positive, but a substantial minority stain only with PAS, indicating that they contain serous granules. By comparison, all secretory cells in the submandibular gland stain with PAS but not with AB after the initial appearance of secretory granules a t 18 days. From 20 days to birth (at 22 days), the cells with mixed granules disappear, while the cells with serous granules become fewer in number and displaced to the peripheral outpocketings of the acini. As a result of these changes, the general organization in the newborn is similar to that in the adult, i.e., purely mucous acini with serous demilunes.The major sublingual gland of the rat consists largely of mucous acini which are capped with serous demilunes. Both of these secretory components of the adult gland have been reported to be present by the time of birth (22 days postconception) (Leeson and Booth, '61). This rapid progression to the adult condition is in striking contrast to the developmental sequence that occurs in the closely-apposed submandibular gland. During the prenatal period of submandibular morphogenesis, the terminal tubules acquire, sequentially, several types of secretion granules (Dvorak, '69; Cutler and Chaudhry, '74). Following birth, the serous granules of the primitive acini disappear, to be replaced by the electron-lucent granules typical of the adult acini (Bressler, '73; Cutler and Chaudhry, '74). With the onset of puberty, another type of serous granule is produced in the distal segments of the striated ducts, and these granular ducts then synthesize the trypsin-and chymotrypsin-like proteases that are characteristic secretory products of the adult gland (Sreebny et al., '55; Riekkinen and Hopsu, '65; Riekkinen and Hopsu-Havu, '66; Cutler and Chaudhry, '75).While the prenatal differentiation of the submandibular gland of the rat has been described thoroughly, that of the sublingual gland is not well-known. A good description of its postnatal development is available (Leeson and Booth, '611, but the only...

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A Stage-Restricted Secretory System in the Submandibular Gland of the Neonatal Rat

Cited by 19 publications

References 29 publications

Salivary Glands: A Paradigm for Diversity of Gland Development

Salivary Glands: A Paradigm for Diversity of Gland Development

Persistence of a perinatal cellular phenotype in submandibular glands of adult rat.

Cytodifferentiation of secretory cells in the sublingual gland of the prenatal rat: A histological, histochemical and ultrastructura study

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