A stable nanoscaled Zr-MOF for the detection of toxic mycotoxin through a pH-modulated ratiometric luminescent switch

Guo, Xiaolei; Zhu, N; Lou, Yue; Ren, Siyuan; Pang, Shirui; He, Yiqiang; Chen, Xiaobo; Shi, Zhan; Feng, Shouhua

doi:10.1039/d0cc01006e

Cited by 50 publications

(26 citation statements)

References 29 publications

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“…of the carboxyl group of the porphyrin to unsaturated sites of Zr6 [60]. The successful synthesis of PCN−224 NPs was demonstrated by the above results.…”

Section: Characteristics Of Pcn−224 Npsmentioning

confidence: 54%

“…The XPS spectrum of Zr 3d (Figure S3) shows that compared with the standard spectrum data (182.4 ev), the Zr 3d 5/2 peak shifts 0.2 eV toward the lower binding energy. This shift indicates the charge redistribution within Zr6 nodes in PCN−224 NPs, suggesting the successful coordination of the carboxyl group of the porphyrin to unsaturated sites of Zr6 [60]. The successful synthesis of PCN−224 NPs was demonstrated by the above results.…”

Section: Characteristics Of Pcn−224 Npsmentioning

confidence: 63%

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Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Zhang

Mao

et al. 2021

Polymers

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The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the ‘MOF-first’ strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN−224 NPs) were pre-synthesized first, and then the composite antibacterial PCN−224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM−25 NFMs have the best 1O2 generation performance, triggering remarkable photodynamic antibacterial effects against both S. aureus, MRSA, and E. coli bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance.

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“…of the carboxyl group of the porphyrin to unsaturated sites of Zr6 [60]. The successful synthesis of PCN−224 NPs was demonstrated by the above results.…”

Section: Characteristics Of Pcn−224 Npsmentioning

confidence: 54%

Section: Characteristics Of Pcn−224 Npsmentioning

confidence: 63%

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Zhang

Mao

et al. 2021

Polymers

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“…The S 2p peaks appeared at 167.7, 163.5, and 162.3 eV [22] (Figure 6B), and the binding energies of Zr 3d 5/2 and Zr 3d 3/2 peaks clearly showed two sharp peaks at 183.9 eV and 181.5 eV, respectively. Compared with the XPS curve of PCN‐224 [23], the binding energy of both peaks decreased by 1.3 eV (Figure 6C). These shifts indicated that the Zr atoms were more negatively charged after the introduction of l ‐Cys, and the charge in the Zr 6 nodes was redistributed [24], which suggested that the carboxylic group of l ‐Cys coordinated with the unsaturated site of Zr 6 of PCN‐224.…”

Section: Resultsmentioning

confidence: 96%

“…Carboxyl and phenyl groups in TCPP decomposed sharply at 350°C and the decomposition of the porphyrin ring was attributed to the loss beyond 430°C, leaving behind ZrO 2 [31]. Moreover, TGA data showed that l ‐Cys‐PCN‐224 possessed relatively lower thermal stability than PCN‐224 [23], which mainly depended on the weak stability of the incorporated l ‐Cys ligand [26].…”

Section: Resultsmentioning

confidence: 99%

One‐pot synthesis of a novel chiral Zr‐based metal‐organic framework for capillary electrochromatographic enantioseparation

Gao

Qin

et al. 2022

Electrophoresis

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A novel chiral stationary phase (CSP) of Zr-based metal-organic framework, l-Cys-PCN-224, was prepared by one-pot method and applied for the enantioseparation by capillary electrochromatography. The CSP was characterized by X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, Fourier-transform infrared spectra, nitrogen adsorption/desorption, circular dichroism spectrum, zeta-potential, and so on. The results revealed that the CSP had good crystallinity, high specific surface area (2580 m 2 /g), and good thermal stability. Meanwhile, the cross-section of l-Cys-PCN-224-bonded opentubular (OT) column was observed by a scanning electron microscope, which proved the successful bonding of l-Cys-PCN-224 particles to the inner wall. Relative standard deviations of the column efficiencies were 3.87%-9.14%, and not obviously changed after 200 runs, which indicated that l-Cys-PCN-224-bonded OT column had the better stability and reproducibility. Excellent chiral separation performance was verified with nine kinds of natural amino acids including acidic, neutral, and basic as the analytes. All amino acids studied achieved good separation with the resolution of 1.38-13.9 and selector factor of 1.11-3.71. These results demonstrated that the CSP had an excellent potential in the chiral separation field.

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“…An aluminum-based MOF with 5-vinyl isophthalic acid (H 2 IPA-V) and 1,3-benzenedicaroxylic acid (H 2 IPA) as an organic ligand were also designed for fluorescence sensing of hydrogen sulfide [ 83 ]. By generating a ground state complex between the vinyl of organic ligand and hydrogen sulfide, a hydrogen sulfide was able to quench the fluorescence emission of this MOF within 10 s. This sensor can effectively determine hydrogen sulfide among various organic molecules and anions with the LOD value of 1.65 µM for hydrogen sulfide.…”

Section: Nmofs For Food Qualitymentioning

confidence: 99%

Nanoscale Metal-Organic Frameworks as Fluorescence Sensors for Food Safety

et al. 2021

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Food safety has attracted attention worldwide, and how to detect various kinds of hazardous substances in an efficient way has always been a focus. Metal-Organic Frameworks (MOFs) are a class of hybrid porous materials formed by organic ligand and metal ions. Nanoscale MOFs (NMOFs) exhibit great potential in serving as fluorescence sensors for food safety due to their superior properties including high accuracy, great stability, fast response, etc. In this review, we focus on the recent development of NMOFs sensing for food safety. Several typical methods of NMOFs synthesis are presented. NMOFs-based fluorescence sensors for contaminants and adulterants, such as antibiotics, food additives, ions and mycotoxin etc. are summarized, and the sensing mechanisms are also presented. We explore these challenges in detail and provide suggestions about how they may be surmounted. This review could help the exploration of NMOFs sensors in food related work.

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A stable nanoscaled Zr-MOF for the detection of toxic mycotoxin through a pH-modulated ratiometric luminescent switch

Abstract: A stable nanoscaled single-excitation ratiometric luminescent pH sensor (MPDB-PCN) for highly sensitive real-time detection of toxic mycotoxin (3-NPA) in complicated environments.

Cited by 50 publications

References 29 publications

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application

One‐pot synthesis of a novel chiral Zr‐based metal‐organic framework for capillary electrochromatographic enantioseparation

Nanoscale Metal-Organic Frameworks as Fluorescence Sensors for Food Safety

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