“…Table 1 displays a comparison of LA-AgNPRs-based colorimetric method with the reported methods for sensing of GABA, selenite, and myoglobin. [35][36][37][39][40][41][43][44][45][61][62][63][64][65][66][67][68] It can be noticed that LA-AgNPRs acted as promising colorimetric sensor for simultaneous detection of three analytes and the LODs of the method either comparable or superior to the reported methods, signifying the potentiality of the method for three analytes assay.…”
Silver nanoprisms (AgNPRs) are synthesized by silver nitrate through chemical reduction method using sodium borohydride and hydrogen peroxide. AgNPRs were functionalized with lipoic acid (LA) and successfully integrated with UV‐visible spectrophotometry for simultaneous detection of multiple biomarkers such as γ‐aminobutyric acid (GABA), selenite, and myoglobin. The as‐prepared LA‐AgNPRs exhibited surface plasmon resonance (SPR) characteristic peak at 660 nm. The SPR band of LA‐AgNPRs was blue‐shifted to 439, 390, and 479 nm upon the addition of GABA, selenite, and myoglobin, respectively. The limits of detection are 6.32, 0.35 and 20.40 nM for GABA, selenite, and myoglobin, respectively. The LA‐AgNPRs sensor displays potential prospect to detect three biomarkers GABA, selenite, and myoglobin in biofluid samples.
“…Table 1 displays a comparison of LA-AgNPRs-based colorimetric method with the reported methods for sensing of GABA, selenite, and myoglobin. [35][36][37][39][40][41][43][44][45][61][62][63][64][65][66][67][68] It can be noticed that LA-AgNPRs acted as promising colorimetric sensor for simultaneous detection of three analytes and the LODs of the method either comparable or superior to the reported methods, signifying the potentiality of the method for three analytes assay.…”
Silver nanoprisms (AgNPRs) are synthesized by silver nitrate through chemical reduction method using sodium borohydride and hydrogen peroxide. AgNPRs were functionalized with lipoic acid (LA) and successfully integrated with UV‐visible spectrophotometry for simultaneous detection of multiple biomarkers such as γ‐aminobutyric acid (GABA), selenite, and myoglobin. The as‐prepared LA‐AgNPRs exhibited surface plasmon resonance (SPR) characteristic peak at 660 nm. The SPR band of LA‐AgNPRs was blue‐shifted to 439, 390, and 479 nm upon the addition of GABA, selenite, and myoglobin, respectively. The limits of detection are 6.32, 0.35 and 20.40 nM for GABA, selenite, and myoglobin, respectively. The LA‐AgNPRs sensor displays potential prospect to detect three biomarkers GABA, selenite, and myoglobin in biofluid samples.
“…Many isoindoles are fluorescent and have found recent and widespread use in analytical methods for the detection of amino acids [42][43][44][45] and other amine-containing compounds. 46 In such methods, the amino acids or amines are derivatized as fluorescent isoindoles 23 via a condensation reaction between their amino groups 22 and ortho-phthalaldehyde (OPA, 21) (Scheme 3).…”
Isoindoles are highly reactive aromatic heterocycles that have a variety of important applications in areas such as medicine, analytical detection, and solar energy. Due to their highly reactive nature, isoindoles can be used to access their derivatives, which possess a diverse array of biological activities. However, their reactivity also makes isoindoles unstable and thus, difficult to prepare. Consequently, there has been a need for the development of novel methods that address some of the synthetic challenges and limitations, as well as reactions that utilize isoindoles to access potentially useful compounds. This review will give an overview of the novel reactions reported within the past decade (2012 to 2022) that involve 2H- and 1H-isoindoles and fused isoindoles as reactants, key intermediates, or products. This review is divided into two parts, with the first part focusing on the synthesis of isoindoles and the second part focusing on reactions of isoindoles. The scopes and limitations of the methods described therein will be discussed and the significance of their contributions to the literature will be highlighted. Similar reactions will also be compared.1 Introduction2 Synthesis of Isoindoles2.1 Synthesis of 2H-Isoindoles2.2 Synthesis of 1H-Isoindoles3 Reactions of Isoindoles3.1 Reactions of 2H-Isoindoles3.2 Reactions of 1H-Isoindoles4 Conclusions
“…The Myo-MIP PHEMATrp nanoparticles were then coated on the SPR sensor's gold surface and were used for the detection of myoglobin in aqueous solutions as well as in serum samples. [10] Assessment of the GABA level in biofluids is crucial for clinical and biochemical research, and detection techniques like electrochemistry, [11] high-performance liquid chromatography, [12,13] Raman spectroscopy, [14] fiber-optic sensor, [15] and colorimetry [16] have been reported for the detection of GABA. However, the lengthy timeframes, complex sample pretreatments, and high cost of these approaches render them ineffective for the efficient measurement.…”
The fabrication of stable fluorescent MoNCs (molybdenum nanoclusters) in aqueous media is quite challenging as it is not much explored yet. Herein, we report a facile and efficient strategy for fabricating MoNCs using 2,3 dialdehyde maltose‐cysteine Schiff base (DAM‐cysteine) as a ligand for detecting myoglobin and γ‐aminobutyric acid (GABA) in biofluids with high selectivity and sensitivity. The DAM‐cysteine‐MoNCs displayed fluorescence of bright blue color under a UV light at 365 nm with an emission peak at 444 nm after excitation at 370 nm. The synthesized DAM‐cysteine‐MoNCs were homogeneously distributed with a mean size of 2.01 ± 0.98 nm as confirmed by the high‐resolution transmission electron microscopy (HR‐TEM). Further, X‐ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT‐IR) techniques were utilized to confirm the elemental oxidation states and surface functional groups of the DAM‐cysteine‐MoNCs. After the addition of myoglobin and GABA, the emission peak of DAM‐cysteine‐MoNCs at 444 nm was significantly quenched. This resulted in the development of a quantitative assay for the detection of myoglobin (0.1–0.5 μM) and GABA (0.125–2.5 μM) with the lower limit of detection as 56.48 and 112.75 nM for myoglobin and GABA, respectively.
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