A Stable, Label-free Optical Interferometric Biosensor Based on TiO<sub>2</sub> Nanotube Arrays

Mun, Kyu-Shik; Alvarez, Sara D.; Choi, Won‐Youl; Sailor, Michael J.

doi:10.1021/nn901312f

Cited by 204 publications

(161 citation statements)

References 52 publications

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“…TiO 2 -based materials are widely applied in sensors [4][5][6][7][8][9] , pollutant degradation 10 , hydrogen generation 11 , bio-applications 12,13 , and photocatalysis [14][15][16][17][18] . Owing to their one-dimensional nature, TiO 2 nanotubes offer a high surface area (1000 m 2 g -1…”

Section: Introductionmentioning

confidence: 99%

Evolution of TiO2 Nanotubular Morphology Obtained in Ethylene Glycol/Glycerol Mixture and its Photoelectrochemical Performance

et al. 2017

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The evolution of TiO 2 nanotubular morphology, synthesized in a mixture of fluorinated ethylene glycol and glycerol electrolyte, was studied as a function of the anodization time. The samples were characterized by FEG-SEM, XRD, XPS, UV-Vis and EIS. The formation of single-or double-walled TiO 2 nanotube structure can be efficiently controlled by the anodization time. For anodization times less than 30 minutes, a compact oxide layer is formed, followed by double-walled nanotube formation up to 120 minutes and single-walled nanotubes up to 240 minutes. XPS analyses show that the samples obtained with short anodization time have a high carbon content and oxygenated surface species compared to the longer-time anodized sample; however, binding energy peaks for Ti 2p remained invariant. The performances of TiO 2 nanotubular photoelectrodes were evaluated in photoelectrochemical water splitting where TiO 2 nanotubes anodized for 120 minutes presented the best performance that was related to their optimal morphology and charge transportation.

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Section: Introductionmentioning

confidence: 99%

Evolution of TiO2 Nanotubular Morphology Obtained in Ethylene Glycol/Glycerol Mixture and its Photoelectrochemical Performance

et al. 2017

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“…Whilst the majority of optical interferometric biosensors have been implemented with optical waveguides [9][10][11], optical fiber based implementation can offer an important addition as the fibers can be fusion-spliced together, leading to an all-fiber configuration. This eliminates the mechanicallyinduced errors often associated with optical alignment in bulk-optic systems and thus is particularly attractive for applications requiring portability such as in-field surveillance of pathogens.…”

Section: Introductionmentioning

confidence: 99%

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Nguyen

Hill

Warren‐Smith

et al. 2015

Sensors and Actuators B: Chemical

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In all cases accepted manuscripts should:  link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article Abstract: This work presents a novel biosensor using the multimode interference effect in an exposed core microstructured optical fiber (ECF). In this work biotin molecules are immobilized onto the ECF core surface to serve as the capturing probe for streptavidin, the target molecules.Since each distinct guided mode in the ECF interacts with the surrounding medium differently, the interference between any two specific modes will experience a fringe shift (or phase change) upon a change in the refractive index (RI) of the surrounding medium, or a localized RI change on the surface of the ECF core as a result of a biological binding event. In our experiment, the interferometric sensing platform was realized by splicing a section of ECF with lead-in and leadout single mode fibers (SMFs). An interference pattern is obtained in the transmission spectrum as the result of multiple excited modes (excited and re-collected at the lead-in and lead-out splicing points) propagating in the ECF with different propagation constants. The interference pattern is non-uniform, indicating that there are more than two modes involved. Fast Fourier transform (FFT) is used to separate individual interference patterns that contribute to this complex spectrum and monitor their phase changes upon RI variation of the surrounding medium. In this way multiple RI sensitivities can be realized because each spatial frequency possesses a distinct sensitivity with respect to the surrounding RI. The operation of this device was validated by measuring the phase changes that occur when the sensing platform was subjected to solutions of different RIs or functionalized with different molecules. A biosensor was demonstrated based on this novel platform using biotin as the capturing probe to detect streptavidin with low non-specific adsorption. The proposed platform is reliable, cost-effective, and offers a potential label-free biosensing alternative to the widely used surface plasmon resonance (SPR) technique.

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“…22,26 During this process, deionized water flowed through the dental implant with rhBMP-2-loaded TiO 2 nanotube arrays. The change in optical thickness with rhBMP-2 was monitored in real time.…”

Section: Resultsmentioning

confidence: 99%

Improved osseointegration of dental titanium implants by TiO2 nanotube arrays with recombinant human bone morphogenetic protein-2: a pilot in vivo study

Lee¹,

Choi²,

Jang³

et al. 2015

IJN

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TiO 2 nanotube arrays on the surface of dental implants were fabricated by two-step anodic oxidation. Their effects on bone-implant contact were researched by a pilot in vivo study. The implants were classified into four groups. An implant group with TiO 2 nanotube arrays and recombinant human bone morphogenetic protein-2 (rhBMP-2) was compared with various surface implants, including machined surface, sandblasted large-grit and acid-etched surface, and TiO 2 nanotube array surface groups. The diameter of the TiO 2 nanotube window and TiO 2 nanotube were ~70 nm and ~110 nm, respectively. The rhBMP-2 was loaded into TiO 2 nanotube arrays and elution was detected by an interferometric biosensing method. A change in optical thickness of ~75 nm was measured by flow cell testing for 9 days, indicating elution of rhBMP-2 from the TiO 2 nanotube arrays. For the in vivo study, the four groups of implants were placed into the proximal tibia of New Zealand White rabbits. In the implant group with TiO 2 nanotube arrays and rhBMP-2, the bone-to-implant contact ratio was 29.5% and the bone volume ratio was 77.3%. Bone remodeling was observed not only in the periosteum but also in the interface between the bone and implant threads. These values were higher than in the machined surface, sandblasted large-grit and acid-etched surface, and TiO 2 nanotube array surface groups. Our results suggest that TiO 2 nanotube arrays could potentially be used as a reservoir for rhBMP-2 to reinforce osseointegration on the surface of dental implants.

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A Stable, Label-free Optical Interferometric Biosensor Based on TiO₂ Nanotube Arrays

Cited by 204 publications

References 52 publications

Evolution of TiO2 Nanotubular Morphology Obtained in Ethylene Glycol/Glycerol Mixture and its Photoelectrochemical Performance

Evolution of TiO2 Nanotubular Morphology Obtained in Ethylene Glycol/Glycerol Mixture and its Photoelectrochemical Performance

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Improved osseointegration of dental titanium implants by TiO2 nanotube arrays with recombinant human bone morphogenetic protein-2: a pilot in vivo study

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A Stable, Label-free Optical Interferometric Biosensor Based on TiO2 Nanotube Arrays

Cited by 204 publications

References 52 publications

Evolution of TiO2 Nanotubular Morphology Obtained in Ethylene Glycol/Glycerol Mixture and its Photoelectrochemical Performance

Evolution of TiO2 Nanotubular Morphology Obtained in Ethylene Glycol/Glycerol Mixture and its Photoelectrochemical Performance

Interferometric-type optical biosensor based on exposed core microstructured optical fiber

Improved osseointegration of dental titanium implants by TiO2 nanotube arrays with recombinant human bone morphogenetic protein-2: a pilot in vivo study

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Product

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A Stable, Label-free Optical Interferometric Biosensor Based on TiO₂ Nanotube Arrays