A spontaneous chicken chimaera

Hála, K; Vilhelmová, M; Schulmanová, Jana; Sainerová, H

doi:10.1007/bf02034670

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…In 136 animals, they found two recombinants. The phenomenon of spontaneous chicken chimerism [41] should, however, be considered as it occurs more frequently and in the case of serological analysis, may appear as a recombinant. Very little data exists on recombination between L and the F-G regions.…”

Section: Comparison Of Chicken and Mammalian Mhcmentioning

confidence: 99%

Chicken Major Histocompatibility Complex and Disease

Hála¹,

Boyd²,

Wick³

1981

Scand J Immunol

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The chicken MHC (B complex) initially described by Briles as controlling blood antigens, is now known to be composed of at least three regions, L, F and G. Two of these, F and G, were described on the basis of recombinants found in a study of over 10,000 chickens. On the basis of biochemical, tissue distribution and functional analyses, F corresponds to the murine H-2 K/D regions. The G region is unique to the chicken since the antigenic product is expressed only on erythrocytes and their progenitors. L was identified by serological studies and corresponds to the H-2 I region; the L antigen is expressed predominantly on B lymphocytes, monocytes and 10% of T lymphocytes, and differences in the L region result in variations in immune responsiveness. A number of functional similarities exist between the chicken MHC and that of other species such as regulation of graft rejection, graft-versus-host reaction (GVHR) and mixed lymphocyte reactions (MLR), mitogenic and immune responsiveness and resistance to RNA and DNA virus infection. The chicken MHC also controls the severity of autoimmune disease, as exemplified by the spontaneous thyroiditis of Obese strain (OS) chickens. It differs from mammalian MHC's by having of lower crossing-over frequency and no apparent gene duplication.

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Section: Comparison Of Chicken and Mammalian Mhcmentioning

confidence: 99%

Chicken Major Histocompatibility Complex and Disease

Hála¹,

Boyd²,

Wick³

1981

Scand J Immunol

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“…The Southern blots were repeated twice. In 1978, a phenomenon called spontaneous chimerism was reported by Hála et al . (1978).…”

Section: Linkage Mapping Of the B-l B Restriction Fragments To Eithermentioning

confidence: 91%

A polymorphic major histocompatibility complex class II‐like locus maps outside of both the chicken B‐system and Rfp‐Y‐system

Juul‐Madsen

Dalgaard

Guldbrandtsen

et al. 2000

European Journal of Immunogenetics

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Chickens have two major regions encoding major histocompatibility complex (MHC) class Ialpha genes and MHC class IIss genes, the serological and functional B-system and the Rfp-Y-system. Recently, they have been shown to assort in a genetically independent way although still located on the same microchromosome. Moreover, the monomorphic MHC class IIalpha gene maps at a third locus located 5 cM from the nearest class IIss genes, located in the B-system (Kaufman et al., 1995). A pedigree family was studied in three generations in order to assign MHC class IIss restriction fragments observed in Southern blot analyses to either the B-system, the Rfp-Y-system or the B-Lalpha locus. In this study, we demonstrate by classical genetic testing of chickens within this fully pedigreed family the existence of an MHC class II-like polymorphic restriction fragment that segregates independently of the B-system, the Rfp-Y-system and of the B-Lalpha locus.

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