A Spontaneous Canine Model of Mucous Membrane (Cicatricial) Pemphigoid, an Autoimmune Blistering Disease Affecting Mucosae and Mucocutaneous Junctions

Olivry, Thierry; Dunston, Stanley M.; Schachter, Marianne; Xu, Luting; Ngôn, Nguyễn Chí; Marinkovich, M. Peter; Chan, Lawrence S.

doi:10.1006/jaut.2001.0510

Cited by 32 publications

(47 citation statements)

References 35 publications

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“…Whereas genetic vesicular diseases (ie, mechanobullous dermatoses of the hereditary epidermolysis bullosa group) are classified on the basis of clefting level and causative mutated genes, autoimmune subepidermal blistering diseases (AISBDs) are separated on the basis of clinical signs and targeted autoantigens. At this time, canine AISBDs are a group of heterogeneous skin diseases that encompass, in order of historical description, bullous pemphigoid (BP), 1 epidermolysis bullosa acquisita (EBA), 9 type I bullous systemic lupus erythematosus, 10 linear immunoglobulin A bullous disease (LAD), 6 mucous membrane pemphigoid (MMP), 8 junctional EBA, and mixed AISBDs. 7 Whereas trained specialists can make diagnoses based on unique clinical phenotypes (eg, bilaterally symmetrical erosions and ulcers affecting several mucous membranes in MMP, blisters and erosions affecting friction areas and footpads in EBA) 8,9 or the presence of characteristic histological findings (eg, eosinophil-rich subepidermal vesicles in BP), 3 they cannot diagnose most entities without the identification of targeted autoantigens.…”

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confidence: 99%

Usefulness of Collagen IV Immunostaining for Diagnosis of Canine Epidermolysis Bullosa Acquisita

Olivry

Dunston

2010

Vet Pathol

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In dogs, autoimmune subepidermal blistering diseases (AISBDs) encompass several distinct entities that exhibit varying clinical signs, microscopic characteristics, prognosis, and response to treatment. The identification of targeted autoantigens is usually required to make the diagnosis, but immunological tests to determine these antigens are not commercially available. Epidermolysis bullosa acquisita (EBA) is an AISBD characterized by the production of autoantibodies against collagen VII in sublamina densa anchoring fibrils. This article reports on the usefulness of collagen IV immunostaining on paraffin-embedded skin biopsies as an aid to diagnose EBA in dogs. In this disease, collagen IV, which forms the fibrous 2-dimensional network of lamina densa, is detected more commonly above subepidermal vesicles than below. In other canine AISBDs, this is rarely the case. Collagen IV immunostaining therefore offers an inexpensive means to help making a suggestive diagnosis of EBA in the absence of serological determination of the targeted autoantigen.

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confidence: 99%

Usefulness of Collagen IV Immunostaining for Diagnosis of Canine Epidermolysis Bullosa Acquisita

Olivry

Dunston

2010

Vet Pathol

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“…The clinical features were almost identical to autoimmune subepidermal blistering disease (Werner et al 1983;Olivery et al 2001). BP in dogs affects mainly the face and the ventral aspect of the body and, less frequently, the mucous membranes (Scott et al 1980;Favrot et al 2002).…”

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confidence: 68%

Subepidermal blistering disease in a 5-month-old Alaskan Malamute dog with concurrent megaesophagus

Kang

Seung

Lee

et al. 2013

Veterinary Quarterly

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“…To this end, only a small number of experimental models of susceptibility to a single disease have been developed with limited success. 91,[95][96][97] Development of such animal models allowing investigation of the effects of the triggering factors on shared autoimmunity would require genetic manipulations enabling the introduction of elements of susceptibility, ie, human HLA and/ or autoantigen-specific TCR/BCR. Thus, a transgenic mouse model expressing two disease-associated HLA and two TCR/BCR specific for each of the autoantigenic peptides would be most suitable for this purpose.…”

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confidence: 99%

Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity

Glutting

Reche

Fridkis-Hareli³

2011

Immunol Immunogenet Insights

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Abstract:Aim: This study was designed to examine the immunogenetic basis for shared autoimmunity, resulting in autoantigen presentation that leads to the production of two or more disease-specific autoantibodies. Methods: A bioinformatics approach based on peptide binding predictions to disease-associated HLA determinants has been developed and tested here using 11 disease associations between autoimmune systemic and mucocutaneous blistering disorders. Various HLAs associated with antigens within a given "disease model" (set of HLA class II and protein sequences known to be associated with a specific autoimmune disease) were tested and ranked against the antigenic proteins, first with proteins they are known to associate with and then with proteins known to be implicated in a second disease model. In every case binding predictions were compared for different proteins binding to the same HLA. Subsequently, disease-related autoantigens have been tested for their binding affinity against each disease-specific HLA class II protein.Results: For a single HLA haplotype, several binders have been generated from a related autoantigen with the variable binding score. In most cases, the binding score corresponding to the interactions between the autoantigen-derived epitope and the HLA associated with one disease was similar or lower than the interactions between the epitope from proteins associated with the second disease and the same HLA. Notably, there was no compelling promiscuity in peptide binding to each of the HLA molecules, in spite of the promiscuous nature of HLA class II binding. Conclusions:The data suggest that, in susceptible individuals, shared autoimmunity might be initiated by two types of HLA/peptide interaction; first between an autoantigen-derived epitope and its disease-associated HLA molecules, and second, between a different peptide of the same autoantigen and HLA proteins specific for the second disease.

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A Spontaneous Canine Model of Mucous Membrane (Cicatricial) Pemphigoid, an Autoimmune Blistering Disease Affecting Mucosae and Mucocutaneous Junctions

Cited by 32 publications

References 35 publications

Usefulness of Collagen IV Immunostaining for Diagnosis of Canine Epidermolysis Bullosa Acquisita

Usefulness of Collagen IV Immunostaining for Diagnosis of Canine Epidermolysis Bullosa Acquisita

Subepidermal blistering disease in a 5-month-old Alaskan Malamute dog with concurrent megaesophagus

Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity

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