A split-mouth randomized clinical trial to evaluate the effect of local and systemic administration of vitamin C on extraction wound healing

Yingcharoenthana, Sarinya; Ampornaramveth, Ruchanee Salingcarnboriboon; Subbalekha, Keskanya; Sinpitaksakul, Phonkit; Kamolratanakul, Paksinee

doi:10.2334/josnusd.20-0515

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…Studies have found that antioxidant cocktail therapy has no effects on bone resorption or formation ( 130 ). Epidemiologic studies showed that although systemic administration of vitamin C improves the soft tissue healing of tooth extraction wounds ( 131 , 132 ), there is no significant difference in the percentage of X-ray density of new bone formation ( 133 ). The main polyphenolic catechins in green tea increase the survival, proliferation, increasesdifferentiation, and mineralization of osteoblasts by promoting osteogenic differentiation of MSCs ( 134 ).…”

Section: Implications For Treatmentmentioning

confidence: 99%

Impact of High-Altitude Hypoxia on Bone Defect Repair: A Review of Molecular Mechanisms and Therapeutic Implications

Chen

Liu

et al. 2022

Front. Med.

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Reaching areas at altitudes over 2,500–3,000 m above sea level has become increasingly common due to commerce, military deployment, tourism, and entertainment. The high-altitude environment exerts systemic effects on humans that represent a series of compensatory reactions and affects the activity of bone cells. Cellular structures closely related to oxygen-sensing produce corresponding functional changes, resulting in decreased tissue vascularization, declined repair ability of bone defects, and longer healing time. This review focuses on the impact of high-altitude hypoxia on bone defect repair and discusses the possible mechanisms related to ion channels, reactive oxygen species production, mitochondrial function, autophagy, and epigenetics. Based on the key pathogenic mechanisms, potential therapeutic strategies have also been suggested. This review contributes novel insights into the mechanisms of abnormal bone defect repair in hypoxic environments, along with therapeutic applications. We aim to provide a foundation for future targeted, personalized, and precise bone regeneration therapies according to the adaptation of patients to high altitudes.

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Section: Implications For Treatmentmentioning

confidence: 99%

Impact of High-Altitude Hypoxia on Bone Defect Repair: A Review of Molecular Mechanisms and Therapeutic Implications

Chen

Liu

et al. 2022

Front. Med.

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“…Among the 18 included studies, there were six studies treating pressure ulcers, with a total of 234 patients [ 9 , 10 , 11 , 12 , 13 , 14 ]. Three studies involved a total of 233 people receiving treatment for dental extractions [ 15 , 16 , 17 ]. Two studies involved a total of 41 patients receiving treatment for foot ulceration [ 6 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Role of Vitamin C in Tissue Healing

2022

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Vitamin C is an essential nutrient for humans and animals which are unable to synthesise it themselves. Vitamin C is important for tissue regeneration due to the role it plays in collagen formation, and its antioxidant properties. We reviewed the literature to evaluate potential associations between vitamin C supplementation and healing of an acute or chronic condition. Embase, Medline, PubMed, and the Cochrane Library were searched for studies published prior to April 2022. Studies were eligible if they reported at least one association between vitamin C supplementation and healing outcomes. Eighteen studies met the inclusion criteria and were included in this review. Overall, vitamin C supplementation improved healing outcomes in certain pathologies, predominantly pressure ulcers. However, many of the studies had small sample sizes, combined nutritional treatments, and did not test baseline vitamin C. Future studies should be of larger scale, exclusively using vitamin C to determine its role in tissue healing in other wounds. We recommend consideration of vitamin C supplementation for people with pressure ulcers.

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“…Investigators within the field of oral surgery have also explored the use of vitamin C in assisting with healing following tooth extraction and dental implant procedures. As a result, there is documented evidence suggesting improved soft tissue regeneration following both procedures compared to control groups who did not receive oral vitamin C supplements after the procedure [ 37 , 38 ]. In addition to wound healing, vitamin C/ascorbic acid proves to be beneficial in ameliorating the negative cosmetic effects of aging.…”

Section: Reviewmentioning

confidence: 99%

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A Review Article

Moore¹,

Khanna²

2023

Cureus

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The outbreak of the COVID-19 pandemic has left clinicians around the world searching for viable prevention and treatment options to use against the virus. The important physiologic properties of vitamin C have been well documented regarding its use by immune cells and its role as an antioxidant. It has previously shown potential as a prophylactic and treatment option for other respiratory viruses, and because of this, there has been intrigue into whether these positive outcomes translate into a cost-effective prevention and treatment option for COVID-19. To this point, there have only been a few clinical trials performed to assess the validity of this notion, with very few showing definitive positive outcomes when vitamin C has been incorporated into prophylactic or treatment protocols to use against coronavirus. When being used to specifically treat the severe complications that arise from COVID-19, vitamin C is a reliable option to treat COVID-19induced sepsis but not pneumonia or acute respiratory distress syndrome (ARDS). As a treatment option, high-dose therapy has shown flashes of promise in a few studies although investigators in these studies often subject the testing group to multimodal therapies that include vitamin C as opposed to just vitamin C alone. Given the role that vitamin C has shown to uphold regarding the human immune response, it is currently advised for all individuals to maintain a normal physiologic range of plasma vitamin C through diet or supplements for adequate prophylactic protection against the virus. More research with definitive outcomes will be needed before it is recommended to provide high-dose vitamin C therapy to prevent or treat COVID-19.

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A split-mouth randomized clinical trial to evaluate the effect of local and systemic administration of vitamin C on extraction wound healing

Cited by 4 publications

References 8 publications

Impact of High-Altitude Hypoxia on Bone Defect Repair: A Review of Molecular Mechanisms and Therapeutic Implications

Impact of High-Altitude Hypoxia on Bone Defect Repair: A Review of Molecular Mechanisms and Therapeutic Implications

A Systematic Review on the Role of Vitamin C in Tissue Healing

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A Review Article

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