A Splicing Transcriptome-Wide Association Study Identifies Candidate Altered Splicing for Prostate Cancer Risk

Sun, Yanfa; Bae, Ye Eun; Zhu, Jingjing; Zhang, Zichen; Zeng, Hua; Cheng, Chun-Mei; Deng, Youping; Wu, Chong; Wu, Lang

doi:10.1089/omi.2023.0065

OMICS: A Journal of Integrative Biology

2023

DOI: 10.1089/omi.2023.0065

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A Splicing Transcriptome-Wide Association Study Identifies Candidate Altered Splicing for Prostate Cancer Risk

Yanfa Sun

Ye Eun Bae

Jingjing Zhu

et al.

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2024

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Cited by 1 publication

References 60 publications

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Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma

Zhu,

Wu,

Liu

et al. 2024

GigaScience

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Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting. Existing blood protein biomarkers for PDAC often suffer from replicability issues, arising from inherent limitations such as unmeasured confounding factors in conventional epidemiologic study designs. To circumvent these limitations, we use genetic instruments to identify proteins with genetically predicted levels to be associated with PDAC risk. Leveraging genome and plasma proteome data from the INTERVAL study, we established and validated models to predict protein levels using genetic variants. By examining 8,275 PDAC cases and 6,723 controls, we identified 40 associated proteins, of which 16 are novel. Functionally validating these candidates by focusing on 2 selected novel protein-encoding genes, GOLM1 and B4GALT1, we demonstrated their pivotal roles in driving PDAC cell proliferation, migration, and invasion. Furthermore, we also identified potential drug repurposing opportunities for treating PDAC. Significance PDAC is a notoriously difficult-to-treat malignancy, and our limited understanding of causal protein markers hampers progress in developing effective early detection strategies and treatments. Our study identifies novel causal proteins using genetic instruments and subsequently functionally validates selected novel proteins. This dual approach enhances our understanding of PDAC etiology and potentially opens new avenues for therapeutic interventions.

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Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma

Zhu,

Wu,

Liu

et al. 2024

GigaScience

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show abstract

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A Splicing Transcriptome-Wide Association Study Identifies Candidate Altered Splicing for Prostate Cancer Risk

Cited by 1 publication

References 60 publications

Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma

Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma

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