A spike generator mechanism model simulates utricular afferents response to sinusoidal vibrations

Budelli, Rubén; Soto, Enrique; González-Estrada, M T; Macadar, O.

doi:10.1007/bf00318419

Cited by 8 publications

(2 citation statements)

References 36 publications

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“…Species with only type II vestibular hair cells (fish and frogs) do show phase locking, but it appears to be usually to lower frequencies than in mammals (Budelli et al 1986). Apparent upper limits are ~900 Hz in frog (Hillery 1984) and 1,000 Hz in fish (without swim bladders) (Popper and Fay 2011).…”

Section: Phase Locking In Vestibular Vs Auditory Neuronsmentioning

confidence: 97%

A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing

Curthoys

Grant

Pastras

et al. 2019

Journal of Neurophysiology

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Older studies of mammalian otolith physiology have focused mainly on sustained responses to low-frequency (<50 Hz) or maintained linear acceleration. So the otoliths have been regarded as accelerometers. Thus evidence of otolithic activation and high-precision phase locking to high-frequency sound and vibration appears to be very unusual. However, those results are exactly in accord with a substantial body of knowledge of otolith function in fish and frogs. It is likely that phase locking of otolith afferents to vibration is a general property of all vertebrates. This review examines the literature about the activation and phase locking of single otolithic neurons to air-conducted sound and bone-conducted vibration, in particular the high precision of phase locking shown by mammalian irregular afferents that synapse on striolar type I hair cells by calyx endings. Potassium in the synaptic cleft between the type I hair cell receptor and the calyx afferent ending may be responsible for the tight phase locking of these afferents even at very high discharge rates. Since frogs and fish do not possess full calyx endings, it is unlikely that they show phase locking with such high precision and to such high frequencies as has been found in mammals. The high-frequency responses have been modeled as the otoliths operating in a seismometer mode rather than an accelerometer mode. These high-frequency otolithic responses constitute the neural basis for clinical vestibular-evoked myogenic potential tests of otolith function.

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Section: Phase Locking In Vestibular Vs Auditory Neuronsmentioning

confidence: 97%

A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing

Curthoys

Grant

Pastras

et al. 2019

Journal of Neurophysiology

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“…This independent evolution of membrane potential has been used in neural modelling, e.g. by Budelli et al (1986). However, we believe now that the modified reset mechanism (3) has a better physiological basis and is also applicable to second-order olfactory neurons and other neurons.…”

Section: Axonal Potentialmentioning

confidence: 98%

Stochastic model neuron without resetting of dendritic potential: application to the olfactory system

Rospars¹,

Lánský

1993

Biol. Cybern.

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A two-dimensional neuronal model, in which the membrane potential of the dendrite evolves independently from that at the trigger zone of the axon, is proposed and studied. In classical one-dimensional neuronal models the dendritic and axonal potentials cannot be distinguished, and thus they are reset to resting level after firing of an action potential, whereas in the present model the dendritic potential is not reset. The trigger zone is modelled by a simplified leaky integrator (RC circuit) and the dendritic compartment can be described by any of the classical one-dimensional neuronal models. The new model simulates observed features of the firing dynamics which are not displayed by classical models, namely positive correlation between interspike intervals and endogenous bursting. It gives a more natural account of features already accounted for in previous models, such as the absence of an upper limit for the coefficient of variation of intervals (i.e. irregular firing). It allows the first- and second-order neurons of the olfactory system to be described with the same basic assumptions, which was not the case in one-point models. Nevertheless it keeps the main qualitative properties found previously, such as the existence of three regimens of firing with increasing stimulus concentration and the sigmoid shape of the firing frequency of first-order neurons as a function of the logarithm of stimulus concentration.

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On Recent Results in Modeling of Sensory Neurons

Lánský

1998

Central Auditory Processing and Neural Modeling

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A spike generator mechanism model simulates utricular afferents response to sinusoidal vibrations

Cited by 8 publications

References 36 publications

A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing

A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing

Stochastic model neuron without resetting of dendritic potential: application to the olfactory system

On Recent Results in Modeling of Sensory Neurons

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