A Spheroid‐Forming Hybrid Gold Nanostructure Platform That Electrochemically Detects Anticancer Effects of Curcumin in a Multicellular Brain Cancer Model

Suhito, Intan Rosalina; Angeline, Novi; Lee, Kwang-Ho; Kim, Huijung; Park, Chun Gwon; Luo, Zhengtang; Kim, Tae-Hyung

doi:10.1002/smll.202002436

Cited by 14 publications

(21 citation statements)

References 56 publications

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“…Figure 3 depicts the DPV voltammograms of c‐Fe and c‐Zn samples obtained from the DPV analysis performed after 1, 7, and 14 days of immersion. DPV technique has been intensively used to characterize the curcumin release in a medium as well as to characterize the curcumin redox reaction based on the oxidation peaks of curcumin 32,45‐48 . In these voltammograms, two curcumin oxidation peaks can be observed after Day 7 and Say 14 of immersion for c‐Zn and after 14 days of immersion for c‐Fe.…”

Section: Resultsmentioning

confidence: 99%

Degradation‐triggered release from biodegradable metallic surfaces

et al. 2021

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This work is dedicated to the investigation of drug‐release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin‐coated zinc (c‐Zn) had a higher degradation rate compared to curcumin‐coated Fe (c‐Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove‐like degradation structure of c‐Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c‐Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus.

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Section: Resultsmentioning

confidence: 99%

Degradation‐triggered release from biodegradable metallic surfaces

et al. 2021

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“…The signal was enhanced using ECM coating before the cell culture was placed on the ECM-coated hybrid platform, indicating the ability of ECM to accelerate cell-substrate interaction. Recently, Suhito et al (2020) proposed a bio-multifunctional platform that can simultaneously perform 3D multicellular cancer spheroid formation and real-time assessment of the anticancer drug treatment (Figure 5A) [145]. The indium tin oxide (ITO) glass electrode was modified with HAuCl 4 via electrodeposition, as previously reported.…”

Section: Electrochemical Detection Of Cancer Cell Viabilitymentioning

confidence: 99%

Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells

2020

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Electrochemical sensors are considered an auspicious tool to detect biomolecules (e.g., DNA, proteins, and lipids), which are valuable sources for the early diagnosis of diseases and disorders. Advances in electrochemical sensing platforms have enabled the development of a new type of biosensor, enabling label-free, non-destructive detection of viability, function, and the genetic signature of whole cells. Numerous studies have attempted to enhance both the sensitivity and selectivity of electrochemical sensors, which are the most critical parameters for assessing sensor performance. Various nanomaterials, including metal nanoparticles, carbon nanotubes, graphene and its derivatives, and metal oxide nanoparticles, have been used to improve the electrical conductivity and electrocatalytic properties of working electrodes, increasing sensor sensitivity. Further modifications have been implemented to advance sensor platform selectivity and biocompatibility using biomaterials such as antibodies, aptamers, extracellular matrix (ECM) proteins, and peptide composites. This paper summarizes recent electrochemical sensors designed to detect target biomolecules and animal cells (cancer cells and stem cells). We hope that this review will inspire researchers to increase their efforts to accelerate biosensor progress—enabling a prosperous future in regenerative medicine and the biomedical industry.

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“…Some researchers have applied the hybrid function platform to MCTs by increasing the electrochemical signal intensity. In one study, a gold-nanostructure-based platform was designed to detect curcumin, which is known as a natural anticancer compound in a brain cancer model (Figure 7A-C) [122]. On this platform, a neuroblastoma (SH-SY5Y) and glioblastoma (U87-MG) were co-cultured to form spontaneous multicellular spheroids without any treatment.…”

Section: Electrochemical Biosensingmentioning

confidence: 99%

Section: Optical Coherence Tomography-based Biosensingmentioning

confidence: 99%

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Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening

Lee

Kim

2021

Biosensors

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Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to their advantage in designing a three-dimensional (3D) solid tumor model. For controlling multicellular cancer spheroids, mimicking the tumor extracellular matrix (ECM) microenvironment is important to understand cell–cell and cell–matrix interactions. In drug cytotoxicity assessments, MCTs provide better mimicry of conventional solid tumors that can precisely represent anticancer drug candidates’ effects. To generate incubate multicellular spheroids, researchers have developed several 3D multicellular spheroid culture technologies to establish a research background and a platform using tumor modelingvia advanced materials science, and biosensing techniques for drug-screening. In application, drug screening was performed in both invasive and non-invasive manners, according to their impact on the spheroids. Here, we review the trend of 3D spheroid culture technology and culture platforms, and their combination with various biosensing techniques for drug screening in the biomedical field.

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A Spheroid‐Forming Hybrid Gold Nanostructure Platform That Electrochemically Detects Anticancer Effects of Curcumin in a Multicellular Brain Cancer Model

Cited by 14 publications

References 56 publications

Degradation‐triggered release from biodegradable metallic surfaces

Degradation‐triggered release from biodegradable metallic surfaces

Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells

Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening

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