A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

Rinaldi, Fabio; Mora, Barbara; Pinto, Daniela; Ramot, Yuval

doi:10.5826/dpc.0704a05

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…By phenotypic analysis, we noticed that the ageing-related hair loss was decreased upon the long-term spermidine supplementation, suggesting a protective role of spermidine against hair loss (alopecia) in aged mice. Interestingly, these data are in line with in vitro findings that spermidine may promote human hair growth [ 47 ] and with clinical trial data indicating that spermidine supplementation may be beneficial against human hair loss [ 49 ]. These results further indicate that the spermidine supplementation per se was effective against age-induced deteriorations.…”

Section: Discussionsupporting

confidence: 79%

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

et al. 2021

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Ageing provokes a plethora of molecular, cellular and physiological deteriorations, including heart failure, neurodegeneration, metabolic maladaptation, telomere attrition and hair loss. Interestingly, on the molecular level, the capacity to induce autophagy, a cellular recycling and cleaning process, declines with age across a large spectrum of model organisms and is thought to be responsible for a subset of age-induced changes. Here, we show that a 6-month administration of the natural autophagy inducer spermidine in the drinking water to aged mice is sufficient to significantly attenuate distinct age-associated phenotypes. These include modulation of brain glucose metabolism, suppression of distinct cardiac inflammation parameters, decreased number of pathological sights in kidney and liver and decrease of age-induced hair loss. Interestingly, spermidine-mediated age protection was associated with decreased telomere attrition, arguing in favour of a novel cellular mechanism behind the anti-ageing effects of spermidine administration.

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Section: Discussionsupporting

confidence: 79%

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

et al. 2021

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“…In addition, the proliferation markers Ki-67 (marker of cellular proliferation) and c-Kit (marker of apoptosis) in the hair roots were investigated. Again, there was a significant difference between both groups in favor of the verum over the placebo group [43].…”

Section: Complex Dietary Supplements For Hair Loss Treatmentmentioning

confidence: 86%

“…Overall, the quality of the studies varies greatly. A total of five studies have been conducted on women [35][36][37][38][39], one study in men [40], and four studies on men and women [41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

Braun

Heinrich

2020

Applied Sciences

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Hair plays a major role in perception within a society. It provides information about gender, age, health, and social status. It is therefore not surprising that those affected are exposed to great suffering due to the widespread occurrence of hair loss. As a result, the demand for new products to remedy this problem is not diminishing. Hair grows in cycles, and a hair follicle goes through several phases called the hair cycle. The active growth phase (anagen phase) lasts 2–6 years. In this state a hair follicle shows a growth of about 1 cm per month. In order to improve the existing hair status, hair should be kept in the active anagen phase as long as possible, or the transition to anagen should be stimulated. A number of reviews already describe the influence of individual active ingredients on hair growth. However, the following review describes existing studies of complex dietary supplements with their experimental weaknesses and strengths and their influence on hair loss. Also, for the determination of hair loss, it is important to use a valid method with high acceptance by the test persons. In this context, the TrichoScale® is a validated and non-invasive tool for quantifying hair loss/hair growth. Thus, it is an ideal measuring instrument to objectively quantify the effectiveness of a hair loss treatment.

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“…Additionally, multiple other epidemiological studies, as outlined above, did not observe cancer-increasing effects of elevated polyamine intake, rather the opposite. Other interesting avenues of polyamine supplementation in humans include the potentially supporting effects on hair growth ( 206 , 207 ).…”

Section: Polyaminesmentioning

confidence: 99%

Caloric Restriction Mimetics in Nutrition and Clinical Trials

et al. 2021

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The human diet and dietary patterns are closely linked to the health status. High-calorie Western-style diets have increasingly come under scrutiny as their caloric load and composition contribute to the development of non-communicable diseases, such as diabetes, cancer, obesity, and cardiovascular disorders. On the other hand, calorie-reduced and health-promoting diets have shown promising results in maintaining health and reducing disease burden throughout aging. More recently, pharmacological Caloric Restriction Mimetics (CRMs) have gained interest of the public and scientific community as promising candidates that mimic some of the myriad of effects induced by caloric restriction. Importantly, many of the CRM candidates activate autophagy, prolong life- and healthspan in model organisms and ameliorate diverse disease symptoms without the need to cut calories. Among others, glycolytic inhibitors (e.g., D-allulose, D-glucosamine), hydroxycitric acid, NAD+ precursors, polyamines (e.g., spermidine), polyphenols (e.g., resveratrol, dimethoxychalcones, curcumin, EGCG, quercetin) and salicylic acid qualify as CRM candidates, which are naturally available via foods and beverages. However, it is yet unclear how these bioactive substances contribute to the benefits of healthy diets. In this review, we thus discuss dietary sources, availability and intake levels of dietary CRMs. Finally, since translational research on CRMs has entered the clinical stage, we provide a summary of their effects in clinical trials.

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A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study

Cited by 8 publications

References 31 publications

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length

What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

Caloric Restriction Mimetics in Nutrition and Clinical Trials

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