A speedy recovery: amphetamines and other therapeutics that might impact the recovery from brain injury

Harbeck-Seu, Anja; Brunk, Irene; Platz, Thomas; Vajkoczy, Peter; Endres, Matthias; Spies, Claudia

doi:10.1097/aco.0b013e328344587f

Cited by 8 publications

(2 citation statements)

References 52 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, astroglial hemichannels were shown to contribute to amplification of inflammatory responses leading to neuronal damages (Bennett et al, ). Thus the inhibitory effects of propofol and ketamine on hemichannel activity in astrocytes may also contribute to their reported neuroprotective effects (Garnier and Bonnet, ; Harbeck‐Seu et al, ), and support the choice of ketamine and propofol for sedation and/or general anesthesia for patients with neuroinflammatory diseases.…”

Section: Discussionmentioning

confidence: 96%

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

Liu

Gangoso

et al. 2015

Glia

View full text Add to dashboard Cite

Astrocytes represent a major non-neuronal cell population actively involved in brain functions and pathologies. They express a large amount of gap junction proteins that allow communication between adjacent glial cells and the formation of glial networks. In addition, these membrane proteins can also operate as hemichannels, through which "gliotransmitters" are released, and thus contribute to neuroglial interaction. There are now reports demonstrating that alterations of astroglial gap junction communication and/or hemichannel activity impact neuronal and synaptic activity. Two decades ago we reported that several general anesthetics inhibited gap junctions in primary cultures of astrocytes (Mantz et al., (1993) Anesthesiology 78(5):892-901). As there are increasing studies investigating neuroglial interactions in anesthetized mice, we here updated this previous study by employing acute cortical slices and by characterizing the effects of general anesthetics on both astroglial gap junctions and hemichannels. As hemichannel activity is not detected in cortical astrocytes under basal conditions, we treated acute slices with the endotoxin LPS or proinflammatory cytokines to induce hemichannel activity in astrocytes, which in turn activated neuronal hemichannels. We studied two extensively used anesthetics, propofol and ketamine, and the more recently developed dexmedetomidine. We report that these drugs have differential inhibitory effects on gap junctional communication and hemichannel activity in astrocytes when used in their respective, clinically relevant concentrations, and that dexmedetomidine appears to be the least effective on both channel functions. In addition, the three anesthetics have similar effects on neuronal hemichannels. Altogether, our observations may contribute to optimizing the selection of anesthetics for in vivo animal studies.

show abstract

Section: Discussionmentioning

confidence: 96%

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

Liu

Gangoso

et al. 2015

Glia

View full text Add to dashboard Cite

show abstract

“…While this early study is encouraging, other subsequent small stroke trials have not been as successful. A recent review analyzed ten clinical trials conducted on stroke patients using D-amphetamine and found that only two reported a significant improvement in neurological outcomes (Harbeck-Seu et al, 2011). Interestingly, adverse events were reported in three trials.…”

Section: Clinical Studiesmentioning

confidence: 97%

The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury

Rau

Ziemniak

Poulsen

2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disorder (ADHD), obesity and narcolepsy. However, methamphetamine has also become a major drug of abuse worldwide. Under conditions of abuse, which involve the administration of high repetitive doses, methamphetamine can produce considerable neurotoxic effects. However, recent evidence from our laboratory indicates that low doses of methamphetamine can produce robust neuroprotection when administered within 12h after severe traumatic brain injury (TBI) in rodents. Thus, it appears that methamphetamine under certain circumstances and correct dosing can produce a neuroprotective effect. This review addresses the neuroprotective potential of methamphetamine and focuses on the potential beneficial application for TBI.

show abstract

Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats

Wang

Xiong

et al. 2015

Neurochem Res

View full text Add to dashboard Cite

Transforming growth factor-β 1 (TGFβ1) has a diverse role in astrogliosis and neuronal survival, but the underlying mechanism remains to be elucidated, especially in traumatic brain injury (TBI). Here, we show that the expression of TGFβ1 was increased in the pericontusional region, accompanied with astrogliosis and neuronal loss in TBI rats. Moreover, TGFβ1 knockdown not only reduced the number of neurons and inhibited astrogliosis but also resulted in a significant neurological dysfunction in rats with TBI. Subsequently, Smad3, a key downstream signal of TGFβ1, was involved in pericontusional region after TBI. These findings therefore indicate that TGFβ1 is involved in neuroprotection and astrogliosis, via activation of down stream Smad3 signal in the brain after injury.

show abstract

A speedy recovery: amphetamines and other therapeutics that might impact the recovery from brain injury

Cited by 8 publications

References 52 publications

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

General anesthetics have differential inhibitory effects on gap junction channels and hemichannels in astrocytes and neurons

The neuroprotective potential of low-dose methamphetamine in preclinical models of stroke and traumatic brain injury

Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats

Contact Info

Product

Resources

About