A Spectrofluorometric Method for the Simultaneous Determination of 2-(5-Hydroxyindol-3-yl) Ethylamine (Serotonin) and 5-Hydroxyindol-3-yl-Acetic Acid in the Brain

Giacalone, E.; Valzelli, L.

doi:10.1159/000136013

Cited by 66 publications

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“…Blood from the decapitated animals was quickly collected for bio chemical assay of total circulating tryptophan. Brain serotonin and 5-hydroxyindoleacetic acid were simul taneously extracted from the same tissue sample ac cording to the method of Giacalone and Valzelli [1969]. Brain and blood tryptophan were extracted according to a slightly modified version of the revised method [Bloxam and Warren.…”

Section: Methodsmentioning

confidence: 99%

<i>p</i>-Chlorophenylalanine-Induced Muricidal Aggression in Male and Female Laboratory Rats

1981

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p-Chlorophenylalanine (pCPA), a potent inhibitor of serotonin synthesis, specifically depletes brain serotonin in a dose-dependent manner. The resulting impairment of serotonergic inhibitory control of the brain is considered responsible for the consequent muricidal aggression that arises in pCPA-treated rats independent of their strain-dependent genetic predisposition and sex propensity to display this behavior. Judging from the data obtained, the minimal impairment of serotonergic inhibitory control required to induce consistent muricidal aggression in rats of both sexes of the strains considered, corresponds to a brain serotonin depletion of about 55–60%.

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Section: Methodsmentioning

confidence: 99%

<i>p</i>-Chlorophenylalanine-Induced Muricidal Aggression in Male and Female Laboratory Rats

1981

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“…The extractions of brain serotonin and 5-hydroxyindoleacctic acid (5-HIAA) were simultaneously performed in the same tissue sample according to the method described by Giacalone and Valzelli (1969), and the identification and measurement of the two brain indoles were made spectrofluorimetrically by means of an Aminco-Bowman apparatus.…”

Section: Methodsmentioning

confidence: 99%

Annual and Daily Changes in Brain Serotonin Content in Differentially Housed Mice

Valzelli¹,

Bernasconi²,

Cusumano³

1977

Neuropsychobiology

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The annual and daily variations of brain serotonin and 5-hydroxyindolacetic acid have been studied over a 6-year period in normally grouped and isolated mice. The results obtained indicate that differences exist between normally grouped and isolated animals, especially when referred to the annual changes to which brain serotonin and 5-hy-droxyindolacetic acid undergo. The results suggest that the outcome of the experiments on neurochemistry, neuropharmacology and behavior can change according to the month of the year and they can further be modified by differential housing of mice.

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“…Blood from the decapitated animals was quickly collected for biochemi cal assay of total circulating tryptophan. Brain seroto nin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) were simultaneously extracted from the same tissue sample according to the method of Giacalone and Valzelli (1969). Brain and blood tryptophan were ex tracted according to a slightly modified version of the revised method (Bloxam and Warren, 1974) of Denckla and Dewey (1967).…”

Section: Methodsmentioning

confidence: 99%

Neurochemical Correlates of Muricidal Behavior in Rats

et al. 1981

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Surgical, pharmacological or environmental manipulation are widely employed to induce muricidal behavior in naive laboratory male rats. The genetic predisposition of an animal strain to kill mice remains, however, an important factor to obtain the muricidal reaction. Data from the pertinent literature suggest that muricidal behavior may possibly be sustained by increased dopaminergic or catecholaminergic activity in the presence of reduced serotoninergic activity. The results here presented indicate, instead, that complete abolition of brain serotoninergic control, i.e., maximal depletion of brain serotonin, is just enough per se to induce muricidal activity. Further, this chemically-induced muricidal activity goes well beyond any pre-existing strain predisposition to kill mice or not.

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A Spectrofluorometric Method for the Simultaneous Determination of 2-(5-Hydroxyindol-3-yl) Ethylamine (Serotonin) and 5-Hydroxyindol-3-yl-Acetic Acid in the Brain

Cited by 66 publications

References 0 publications

<i>p</i>-Chlorophenylalanine-Induced Muricidal Aggression in Male and Female Laboratory Rats

<i>p</i>-Chlorophenylalanine-Induced Muricidal Aggression in Male and Female Laboratory Rats

Annual and Daily Changes in Brain Serotonin Content in Differentially Housed Mice

Neurochemical Correlates of Muricidal Behavior in Rats

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