A spectral CT study on iodine augmentation of radiation therapy and its potential for combination with chemotherapy

Badea, Cristian T.; Ghaghada, Ketan B.; Holbrook, Matthew; Bhandari, Prajwal; Clark, Darin P.; Qi, Yi; Mowery, Yvonne M.

doi:10.1117/12.2549583

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our cancer study, we tested VivoVist's potential to augment the effectiveness of radiotherapy in a radioresistant orthotopic HNSCC mouse model. Barium's high atomic number suggests a potential role in enhancing radiation dose delivery to targeted areas, akin to the use of gold or iodine nanoparticles in radiotherapy [13][14][15][16][17]. This property could be important in refining treatment strategies, including for vascular disruption.…”

Section: Discussionmentioning

confidence: 99%

Enhancing in vivo preclinical studies with VivoVist™ and photon-counting micro-CT imaging

Badea,

Rickard,

Allphin

et al. 2024

Medical Imaging 2024: Clinical and Biomedical Imaging

View full text Add to dashboard Cite

This study investigated the application of VivoVist™, a high-contrast micro-CT contrast agent, in spectral photoncounting (PC) micro-CT imaging in mouse models. With a long blood half-life, superior concentration, and reduced toxicity VivoVist, composed of barium (Ba)-based nanoparticles, offers a cost-effective solution for enhancing computed tomography (CT) imaging. To evaluate its efficacy, we employed an in-house developed spectral micro-CT with a photoncounting detector. VivoVist was administered through retro-orbital injection in a non-tumor-bearing C57BL/6 mouse and in two mice with MOC2 buccal tumors, with scans taken at various post-injection intervals. We used a multi-channel iterative reconstruction algorithm to provide multi-energy tomographic images with a voxel size of 125 microns or 75 microns for high-resolution scans; we performed post-reconstruction spectral decomposition with water, calcium (Ca), iodine (I), and barium (Ba) as bases. Our results revealed effective separation of Ba from I-based contrast agents with minimal cross-contamination and superior contrast enhancement for VivoVist at 39 keV. We also observed VivoVist's potential in delineating vasculature in the brain and its decreasing concentration in the blood over time post-injection, with increased uptake in the liver and spleen. We also explored the simultaneous use of VivoVist and liposomal iodinated nanoparticles in a cancer study involving radiation therapy. Our findings reveal that VivoVist, combined with radiation therapy, did not significantly increase liposomal iodine accumulation within head and neck squamous cell carcinoma tumors. In conclusion, our work confirms VivoVist's promising role in enhancing PCCT imaging and its potential in studying combination therapy, warranting further investigation into its applications in diagnostics and radiotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Enhancing in vivo preclinical studies with VivoVist™ and photon-counting micro-CT imaging

Badea,

Rickard,

Allphin

et al. 2024

Medical Imaging 2024: Clinical and Biomedical Imaging

View full text Add to dashboard Cite

show abstract

Distributions of Intravenous Injected Iodine Nanoparticles in Orthotopic U87 Human Glioma Xenografts Over Time and Tumor Therapy

Ridwan

El-Tayyeb

Hainfeld

et al. 2020

Nanomedicine (Lond.)

View full text Add to dashboard Cite

Aim: To analyze the localization, distribution and effect of iodine nanoparticles (INPs) on radiation therapy (RT) in advanced intracerebral gliomas over time after intravenous injection. Materials & methods: Luciferase/td-tomato expressing U87 human glioma cells were implanted into mice which were injected intravenously with INPs. Mice with gliomas were followed for tumor progression and survival. Immune-stained mouse brain sections were examined and quantified by confocal fluorescence microscopy. Results: INPs injected intravenously 3 days prior to RT, compared with 1 day, showed greater association with CD31-staining structures, accumulated inside tumor cells more, covered more of the tumor cell surface and trended toward increased median survival. Conclusion: INP persistence and redistribution in tumors over time may enable greater RT enhancement and clinically relevant hypo-fractionated-RT and may enhance INP efficacy.

show abstract

A spectral CT study on iodine augmentation of radiation therapy and its potential for combination with chemotherapy

Cited by 2 publications

References 0 publications

Enhancing in vivo preclinical studies with VivoVist™ and photon-counting micro-CT imaging

Enhancing in vivo preclinical studies with VivoVist™ and photon-counting micro-CT imaging

Distributions of Intravenous Injected Iodine Nanoparticles in Orthotopic U87 Human Glioma Xenografts Over Time and Tumor Therapy

Contact Info

Product

Resources

About