2001
DOI: 10.1016/s0960-9822(01)00456-0
|View full text |Cite
|
Sign up to set email alerts
|

A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle

Abstract: Pin2/TRF1 was independently identified as a telomeric DNA binding protein (TRF1) [1] and as a protein (Pin2) that can bind the mitotic kinase NIMA and suppress its ability to induce mitotic catastrophe [2, 3]. Pin2/TRF1 has been shown to bind telomeric DNA as a dimer [3-7] and to negatively regulate telomere length [8-11]. Interestingly, Pin2/TRF1 levels are regulated during the cell cycle, being increased in late G2 and mitosis and degraded as cells exit from mitosis [3]. Furthermore, overexpression of Pin2/T… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

8
66
0

Year Published

2003
2003
2009
2009

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 56 publications
(74 citation statements)
references
References 19 publications
8
66
0
Order By: Relevance
“…2A, middle panel). Moreover, TPX2, a microtubule-associated protein implicated in spindle formation, 13 and TRF1, a telomeric bound protein that interacts specifically with the mitotic spindle, 14 both exhibit normal mitotic distribution in HBx-expressing cells (Fig. 2A, lower panel; and data not shown).…”
Section: Resultsmentioning
confidence: 90%
“…2A, middle panel). Moreover, TPX2, a microtubule-associated protein implicated in spindle formation, 13 and TRF1, a telomeric bound protein that interacts specifically with the mitotic spindle, 14 both exhibit normal mitotic distribution in HBx-expressing cells (Fig. 2A, lower panel; and data not shown).…”
Section: Resultsmentioning
confidence: 90%
“…These results not only confirm that phosphorylation of p70S6K T421/S424 is not always associated with activation of p70S6K, but also demonstrate that phosphorylation of p70S6K T421/S424 Based on our data and that in the literature, Thr 421 and Ser 424 phosphorylation of p70S6K may or may not be important for inhibition of the enzyme. A mitosisrelated inhibitory protein, human prolyl isomerase Pin1, has been shown to inhibit G2/M progression by interacting with phospho-proteins, such as NIMA, Cdc25, and Wee1 (Zhou et al, 1999;Nakamura et al, 2001). Interestingly, Pin1 is reported to interact with p70S6K (Yaffe et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…K5TRF1 but not K5TRF2 cells show aberrant mitotic spindles. In addition to its telomeric roles, TRF1 has been suggested to be part of the mitotic spindle checkpoint (40,43). To address whether K5TRF1 mice showed any defects in spindle formation during mitosis, we first studied the percentage of K5TRF1 keratinocytes showing mitotic spindle defects compared to wild-type controls.…”
Section: Vol 29 2009 Trf1 Regulation Of Telomere Length and Mitosismentioning
confidence: 99%
“…In addition, TRF1 regulates sister telomere cohesion at telomeres through posttranscriptional modification by tankyrase 1 (10,49). TRF1 has also been shown to interact with components of the mitotic spindle, including the mitotic kinase NIMA and the spindle regulator Mad1 (40,43). Furthermore, TRF1 has been shown to interact with microtubules and to control microtubule polymerization (40).…”
mentioning
confidence: 99%
See 1 more Smart Citation