A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene.

Homa, Fred L.; Glorioso, Joseph C.; Levine, Fred

doi:10.1101/gad.2.1.40

Cited by 96 publications

(105 citation statements)

References 48 publications

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“…The size of the crucial 12-bp K8.1 promoter core is similar to that of the herpes simplex virus type 1 gC late promoter core (12). Both are embedded in GC-rich flanking sequences and contain signals essential for fully regulated activation.…”

Section: Figmentioning

confidence: 91%

Requirement of a 12-Base-Pair TATT-Containing Sequence and Viral Lytic DNA Replication in Activation of the Kaposi's Sarcoma-Associated Herpesvirus K8.1 Late Promoter

Tang

Yamanegi

Zheng

2004

J Virol

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Kaposi's sarcoma-associated herpesvirus (KSHV) K8.1 late promoter consists of a minimal 24-bp sequence, with a TATA-like, 12-bp promoter core, AATATTAAAGGG, and is active on a reporter only in butyrate-induced KSHV-infected cells. The activity of the K8.1 promoter can be enhanced (>15-fold) by the KSHV left-end lytic origin of DNA replication (oriLyt-L) sequence while providing inefficient replication of plasmid DNA and is inhibited by viral DNA replication inhibitors, suggesting that activation of the K8.1 promoter on the reporter is involved in KSHV lytic DNA replication largely by trans.

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Section: Figmentioning

confidence: 91%

Requirement of a 12-Base-Pair TATT-Containing Sequence and Viral Lytic DNA Replication in Activation of the Kaposi's Sarcoma-Associated Herpesvirus K8.1 Late Promoter

Tang

Yamanegi

Zheng

2004

J Virol

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“…Presumably, such interactions would involve the amino termini of Fos or Jun and would not occur with the GCN4 activation domain. Another possibility is that Fos and Jun might differ from GCN4 in interacting with the basal transcription machinery at specific promoters; in this regard, certain TATA elements respond differentially to upstream activator proteins (Struhl 1986;Homa et al 1988;Simon et al 1988;Harbury and Struhl 1989;Wefald et al 1990). All of the above models are consistent with the mutational analyses of Jun and Fos in which transcriptional activity correlates well with transformation ability (Bohmann and Tjian 1989;Neuberg et al 1989b;Schuermann et al 1989;Baichwal and Tjian 1990;Alani et al 1991;Binetruy et al 1991;Lucibello et al 1991;Wisdom et al 1992).…”

Section: Mechanistic Implicationsmentioning

confidence: 99%

Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.

Oliviero¹,

Robinson²,

Struhl³

et al. 1992

Genes Dev.

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The Jun and Fos oncoproteins belong to the AP-1 family of transcriptional activators and are believed to induce cellular transformation by inappropriately activating genes involved in cell replication. To determine whether transcriptional activation through AP-1 sites is sufficient for transforming activity, we examined the properties of an autonomous and heterologous AP-1 protein, yeast GCN4, in rat embryo fibroblasts. GCN4 induces transcriptional activation through AP-1 sites but, unlike Jun and Fos, fails to induce cellular transformation, in cooperation with Ha-ras. Jun-GCN4 and Fos-GCN4 homodimers independently induce cellular transformation indicating that the amino-terminal regions of Jun and Fos each contain regulatory functions that are required for oncogenesis but are distinct from generic transcriptional activation domains. In addition, these observations have implications for the nature of the oncogenically relevant target genes that respond to Jun and Fos.

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“…It contains an interrupted repeat of 67 amino acids, a short basic repeat, and a region weakly homologous with bacterial sigma factors (10, 80). In addition to its role in the basal transcription apparatus, TBP also has been shown genetically (27,31,63,69,70) and biochemically (32,35,60,68) to be a likely target for polymerase II upstream activators.Virtually nothing is known about RNA polymerases, …”

mentioning

confidence: 99%

TATA-binding protein and nuclear differentiation in Tetrahymena thermophila.

Stargell¹,

Gorovsky²

1994

Mol. Cell. Biol.

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Unambiguous TATA boxes have not been identified in upstream sequences of Tetrahymena thermophila genes analyzed to date. To begin a characterization of the promoter requirements for RNA polymerase II, the gene encoding TATA-binding protein (TBP) was cloned from this species. The derived amino acid sequence for the conserved C-terminal domain of Tetrahymena TBP is one of the most divergent described and includes a unique 20-amino-acid C-terminal extension. Polyclonal antibodies generated against a fragment of Tetrahymena TBP recognize a 36-kDa protein in macronuclear preparations and also cross-react with yeast and human TBPs.Immunocytochemistry was used to examine the nuclear localization of TBP during growth, starvation, and conjugation (the sexual phase of the life cycle). The transcriptionaily active macronuclei stained at all stages of the life cycle. The transcriptionally inert micronuclei did not stain during growth or starvation but surprisingly stained with anti-TBP throughout early stages of conjugation. Anti-TBP staining disappeared from developing micronuclei late in conjugation, corresponding to the onset of transcription in developing macronuclei. Since micronuclei do not enlarge or divide at this time, loss of TBP appears to be an active process. Thus, the transcriptional differences between macro-and micronuclei that arise during conjugation are associated with the loss of a major component of the basal transcription apparatus from developing micronuclei rather than its appearance in developing macronuclei.TATA-binding protein (TBP) is required for transcription by all three nuclear RNA polymerases. TBP, along with an assortment of distinct TBP-associated factors, has been found to make up the RNA polymerase I selectivity factor I (9, 36), the polymerase II general transcription factor IID (14,73,83), and the RNA polymerase III general transcription factor IIIB (38,43,62,72,75). Given the need for TBP to function in these different complexes in such fundamental cellular processes, it is not surprising that TBP is highly conserved throughout eukaryotes. Yeast and human TBP are functionally interchangeable in basal transcription reactions reconstituted with yeast or human components (5,17,39) and have nearly identical TATA element binding specificities (78). The C-terminal 180 residues of TBP from a variety of organisms are typically 80% identical in amino acid sequence, whereas the N-terminal regions are divergent both in length and in amino acid sequence (6, 16, 20, 26, 28-30, 33, 37, 49, 55, 61). The C-terminal domain is necessary and sufficient for TATA element binding and basal transcription in vitro (28,41,55) and for the essential functions of yeast TBP in yeast cells (10,21,57,84). This region forms an independent structural domain within the context of the intact protein (41). It contains an interrupted repeat of 67 amino acids, a short basic repeat, and a region weakly homologous with bacterial sigma factors (10, 80). In addition to its role in the basal transcription apparatus, TBP also ...

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A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene.

Cited by 96 publications

References 48 publications

Requirement of a 12-Base-Pair TATT-Containing Sequence and Viral Lytic DNA Replication in Activation of the Kaposi's Sarcoma-Associated Herpesvirus K8.1 Late Promoter

Requirement of a 12-Base-Pair TATT-Containing Sequence and Viral Lytic DNA Replication in Activation of the Kaposi's Sarcoma-Associated Herpesvirus K8.1 Late Promoter

Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.

TATA-binding protein and nuclear differentiation in Tetrahymena thermophila.

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