A species dependent response to the pro-epileptic drug pentylentetrazole in birds

Amin, Faridah; Dar, Asim H.; Khan, Osama Sherjeel; Khan, Faezah; Mitha, Rida; Tharwani, Arsal; Haider, Ghulam; Chand, Prem; Arain, Fazal Manzoor

doi:10.1016/j.brainresbull.2017.08.003

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…In the modern research era, pre-clinical trials with most appropriate animal models offer an opportunity to reproduce human diseases with nearly similar symptoms. 29,30 Animal models give us a chance to understand the pathophysiology of epilepsy. 31,32 Choosing a correct animal model is critical and important because age, strain, weight, and gender play vital roles in the development of a model of epilepsy.…”

Section: Animal Models Of Temporal Lobe Epilepsymentioning

confidence: 99%

Temporal lobe epilepsy with hippocampus sclerosis: prevalence, etiology, and treatment options with herbal medicines

Wasim

Musani

Siddiqi

et al. 2023

PJNS

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Background and objectives: Epilepsy is a neurological disorder in which the patient suffers with two or more unprovoked seizures. It is one of the most common neurological disorders worldwide, affecting more than 70 million people. Currently various modes of effective treatments are available, but still there are many cases that remain drug resistant. Hence, there is a need to explore herbal medications for the treatment of drug resistant epilepsy. Methods: Recent reviews and research articles (2000-2022) from PubMed and Google Scholar have been explored. Review: Based on etiology, there are six categories of epilepsy: Genetic, structural, metabolic, immune, infectious, and unknown epilepsy. Temporal lobe epilepsy with hippocampus sclerosis (TLE-HS) is one of the most common forms of structural epilepsy. Even though several new anti-epileptic drugs (AEDs) have been discovered, but the treatment of some cases especially TLE-HS remains resistant to them. Surgery is one of the most effective options for TLE-HS; however, this usually results in memory deficits, and occasionally, intracranial hematoma, delayed hydrocephalus, subdural empyema, and visual field defects in patients. Conclusion: Hence, to overcome drug resistance, new pharmacological and herbal therapies are required. Animal trials are first step in the development of new drugs, to study toxicity and efficacy of proposed drugs. Many herbs have anticonvulsant activity but remain an under-explored treatment option for epilepsy. Further research on herbal extracts as a possible treatment for epilepsy needs to be conducted.

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Section: Animal Models Of Temporal Lobe Epilepsymentioning

confidence: 99%

Temporal lobe epilepsy with hippocampus sclerosis: prevalence, etiology, and treatment options with herbal medicines

Wasim

Musani

Siddiqi

et al. 2023

PJNS

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“…Subcutaneous or intraperitoneal injection of PTZ in rodents or birds can mimic human myoclonus [ 73 , 74 ]. Myoclonus models induced by PTZ are widely used to assess the anticonvulsant effects of AEDs [ 73 , 75 ].…”

Section: Myoclonus Modelsmentioning

confidence: 99%

“…Myoclonus models induced by PTZ are widely used to assess the anticonvulsant effects of AEDs [ 73 , 75 ]. The disadvantage of this model is dose variability, because an appropriate dose is vital for the successful induction of myoclonus [ 74 ]. The related information of the myoclonus models is presented in Table 4 .…”

Section: Myoclonus Modelsmentioning

confidence: 99%

Animal Models of Epilepsy: A Phenotype-oriented Review

Wang¹,

Wei²,

Feng³

et al. 2022

Aging and disease

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Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious damage to brain function, which is usually observed in patients with temporal lobe epilepsy. Controlling seizure attacks is vital for the treatment and prognosis of epilepsy. Animal models, such as the kindling model, which was the most widely used model in the past, allow the understanding of the potential epileptogenic mechanisms and selection of antiepileptic drugs. In recent years, various animal models of epilepsy have been established to mimic different seizure types, without clear merits and demerits. Accordingly, this review provides a summary of the views mentioned above, aiming to provide a reference for animal model selection.

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High resolution functional localization of epileptogenic focus with glutamate and electrical signals detection by ultramicroelectrode arrays

Xiao

Song

et al. 2020

Sensors and Actuators B: Chemical

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A species dependent response to the pro-epileptic drug pentylentetrazole in birds

Cited by 4 publications

References 12 publications

Temporal lobe epilepsy with hippocampus sclerosis: prevalence, etiology, and treatment options with herbal medicines

Temporal lobe epilepsy with hippocampus sclerosis: prevalence, etiology, and treatment options with herbal medicines

Animal Models of Epilepsy: A Phenotype-oriented Review

High resolution functional localization of epileptogenic focus with glutamate and electrical signals detection by ultramicroelectrode arrays

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