A Special Tinea Nigra Caused by Curvularia lunata: Case Report and Literature Review

Al-Odaini, Najwa; Wei, Jin-Ying; Zheng, Yanqing; Zheng, Dongyan; Khader, Jazeer A.; Cao, Cunwei

doi:10.1007/s11046-022-00619-8

Cited by 7 publications

(4 citation statements)

References 68 publications

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“…infections have been associated with natural and nosocomial infections. Examples of infections in people include tinea nigra [ 50 ]; superficial and deep dermatitis [ 49 ]; keratitis [ 41 , 51 ]; endophthalmitis [ 52 ]; periorbital ophthalmitis [ 15 ]; peritonitis [ 53 ]; stomatitis of the hard palate [ 14 ]; encephalitis of the cerebral cortex [ 27 ], midbrain [ 54 ], and brainstem [ 55 ]; and bronchiolitis and pneumonia [ 27 , 56 , 57 ]. Interestingly, Curvularia sp.…”

Section: Discussionmentioning

confidence: 99%

Fungal Rhinosinusitis Caused by a Curvularia sp. Infection in a Female Sumatran Orangutan: A Case Report

et al. 2022

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Mycotic nasal cavity and paranasal sinus infections in non-human primates (NHPs) are relatively uncommon diseases of the upper respiratory tract. This case study describes the clinical and pathological features as well as the diagnostic techniques and interventions applied to treat the associated disease. A 23-year-old primiparous female Sumatran orangutan residing at Perth Zoo in Western Australia developed intermittent episodes of right-sided epistaxis. An ulcerative nasal mass was identified from a diagnostic endoscopy. The mass was initially biopsied and showed the morphological characteristics of a dematiaceous fungal organism upon a histological examination. There were prominent mucosal and submucosal granulomatous infiltrates containing histocytes, giant cells, and lymphocytes admixed with fewer numbers of neutrophils and eosinophils surrounding the fungal organism. The organism was identified as Curvularia sp. by the fungal characteristics associated with the histopathology, culture growth, and PCR analysis. The mass was subsequently removed with endoscopic sinus surgery (ESS) and the orangutan was medically treated with itraconazole for several months. The recovery was uneventful and the orangutan returned to full health.

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Section: Discussionmentioning

confidence: 99%

Fungal Rhinosinusitis Caused by a Curvularia sp. Infection in a Female Sumatran Orangutan: A Case Report

et al. 2022

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“…This change in pigmentation is associated with the natural clearance of the fungus from the affected area during daily activities 1. The main causative species is Hortaea werneckii , but Stenella araguata and Curvularia lunata are less common causes 5. Tinea nigra is common in individuals residing in tropical regions of Central and South America, Africa, and Asia, or those travelling to endemic areas.…”

Section: Answersmentioning

confidence: 99%

“…Tinea nigra is common in individuals residing in tropical regions of Central and South America, Africa, and Asia, or those travelling to endemic areas. It is more common in children 5. Predisposing factors include hyperhidrosis and micro-traumas, running barefoot, or engaging in water sports near rivers or lakes 4…”

Section: Answersmentioning

confidence: 99%

A pigmented macule on the palm

He,

Deng

2023

BMJ

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“…Different classes of antifungals were used in the literature, nevertheless, the optimal antifungal for this infection remains to be determined. We recently reported a novel case of tinea nigra in an immunocompetent child where C. lunata was isolated from the skin lesion [20]. Thus, the main objective of the current study was to investigate the possibility of producing a tinea nigra lesion by experimenting on an animal model, in addition to evaluating the in vitro activity of commonly used antifungals against C. lunata.…”

Section: Introductionmentioning

confidence: 99%

Experimental Phaeohyphomycosis of Curvularia lunata

Al-Odaini

Pan

Liao

et al. 2022

JCM

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Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to Curvularia lunata (C. lunata) in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of C. lunata have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with C. lunata suspension by different routes and the course of infection was evaluated. In addition, the in vitro antifungal susceptibility of C. lunata against six commonly used antifungals was evaluated using the microdilution method. Inoculation resulted in skin lesions in animals inoculated intraperitonially and subcutaneously. Infection was confirmed by both mycological and histopathologic examination. C. lunata spores and hyphae were detected in the histopathologic sections stained with hexamine silver staining. In addition, voriconazole (VRC) demonstrated greater activity against C. lunata when compared to the other antifungals, whereas fluconazole (FLC) was the least active antifungal with a minimum inhibitory concentration (MIC) range of 8–16 μg/mL. Further studies are necessary to understand the pathogenicity of C. lunata and uncover the mystery of this fungus.

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A Special Tinea Nigra Caused by Curvularia lunata: Case Report and Literature Review

Cited by 7 publications

References 68 publications

Fungal Rhinosinusitis Caused by a Curvularia sp. Infection in a Female Sumatran Orangutan: A Case Report

Fungal Rhinosinusitis Caused by a Curvularia sp. Infection in a Female Sumatran Orangutan: A Case Report

A pigmented macule on the palm

Experimental Phaeohyphomycosis of Curvularia lunata

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