A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors

Hurley, C K; Ja, Wade; Oudshoorn, Machteld; Middleton, Derek; Kukuruga, Debra; Navarrete, Cristina; Christiansen, Frank; Hegland, Janet; Ec, Ren; Andersen, Inger Grete Krogh; Sa, Cleaver; Brautbar, Chaim; Raffoux, C

doi:10.1016/s0198-8859(98)00129-3

Cited by 31 publications

(11 citation statements)

References 68 publications

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“…In these cases, higher resolution testing using DNA‐based methods as well as testing of other MHC loci and polymorphisms (e.g. microsatellites) might also be performed (15).…”

Section: Patient Typing Strategiesmentioning

confidence: 99%

Maximizing optimal hematopoietic stem cell donor selection from registries of unrelated adult volunteers

2003

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Today, more than 50 registries of HLA-typed potential adult hematopoietic stem cell donors have been established in 40 countries and include more than 7.5 million volunteers. HLA testing of new volunteers includes HLA-A, -B and often -DR typing at low to intermediate resolution. Searching patients are tested for these same loci, preferably at a higher level of resolution. Over 95,000 patient searches are received by registries annually resulting in approximately 4660 unrelated transplants. In 2001, nearly one-third of transplants involved a patient in one country receiving stem cells from a donor in another. The diversity of the HLA system complicates the search process, requiring sophisticated registry algorithms for matching, and expertise in allele and haplotype frequencies and associations to design search strategies. Within registries, HLA frequency data have been used to evaluate optimal registry size and composition.

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“…In these cases, higher resolution testing using DNA‐based methods as well as testing of other MHC loci and polymorphisms (e.g. microsatellites) might also be performed (15).…”

Section: Patient Typing Strategiesmentioning

confidence: 99%

Maximizing optimal hematopoietic stem cell donor selection from registries of unrelated adult volunteers

2003

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“…The Division of Transfusion Medicine at the University of California, Los Angeles, as a result of a 17-year policy of requiring two independent samples for blood typing before issuing type-specific blood for non-group-O patients, reported a very similar mislabelling rate of 0.44 samples per 1000 22. In keeping with the policy of the University of California, Los Angeles, the World Marrow Donor Association also established guidelines recommending confirmatory tissue typing on duplicate samples from potential donors and recipients before transplantation 28. The policy of confirmatory testing of a second independent blood sample for patients without a historical record corroborating an ABO typing result from a single sample has since been adopted by more transfusion services and now extends to approximately 20% of US laboratory and hospital practices 18…”

Section: Gradient Of Risk Management Strategiesmentioning

confidence: 97%

Quality standards and samples in genetic testing

Ravine

Suthers

2012

J Clin Pathol

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The most critical performance indicator for medical laboratories is the delivery of accurate test results. In any laboratory, there is always the possibility that random or systematic errors may occur and place human health and welfare at risk. Laboratory quality assurance programmes continue to drive improvements in analytical accuracy. The most rigorously scrutinised data on laboratory errors, which come from transfusion medicine, reveal that the incidence of analytical errors has fallen to levels where most of the residual risk is now found in preanalytical links in the chain from patient to result, particularly activities associated with ordering of tests and sample collection. This insight is important for genetic testing because, like pretransfusion testing of patients with unknown blood groups, a substantial proportion of genotyping results cannot be immediately verified. An increasing number of clinical decisions, associated personal and social choices, and legal outcomes are now influenced by genetic test results in the absence of other confirmatory data. An incorrect test result may lead to unnecessary and irreversible interventions, which may in themselves have associated risks for the patient, inaccurate risk assessment regarding the disease, missed opportunities for disease prevention or even wrongful conviction in a court of law. Unfortunately, there is limited information available about the risk of preanalytical errors associated with, and few published guidelines regarding, sample collection for genetic testing. The growing number and range of important decisions made on the basis of genetic findings warrant a reappraisal of current standards to minimise risks in genetic testing.

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“…6 DNAbased typing is generally commissioned by registries, in preference to serology, for all loci tested. 6 DNAbased typing is generally commissioned by registries, in preference to serology, for all loci tested.…”

Section: Donor Typing Strategiesmentioning

confidence: 99%

Stem cell donor registries

Cleaver¹

2009

Hematopoietic Stem Cell Transplantation in Clinical Practice

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A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors

Cited by 31 publications

References 68 publications

Maximizing optimal hematopoietic stem cell donor selection from registries of unrelated adult volunteers

Maximizing optimal hematopoietic stem cell donor selection from registries of unrelated adult volunteers

Quality standards and samples in genetic testing

Stem cell donor registries

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