A special issue on calcium dynamics of the heart: remodeling of ion channels and regulatory pathways

Bare, Dan J.; Yue, Lixia; Ai, Xun

doi:10.1007/s00424-021-02532-3

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Calcium signaling pathways were involved in a majority of DMR-associated genes, such as ANXA2, ATP2A3, and CACNA2D3. Calcium signaling pathways play a key physiological and pathological role in heart function [38]. Calcium-handling genes are important for cardiomyocyte contraction, and mutations in these genes can lead to arrhythmias [39].…”

Section: Differentially Methylated Regions (Dmrs) Of Vsdmentioning

confidence: 99%

DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

Xia,

Tao,

et al. 2024

CHD

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Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed a list of CHD-associated pathways. To further investigate the role of DNA methylation in VSD, data from 7 pairs of MZ twins with VSD were analyzed. We identified 1614 DMRs corresponding to 1443 genes associated with arrhythmogenic right ventricular cardiomyopathy, cyclic guanosine monophosphate-protein kinase G (cGMP-PKG) signaling pathway by KEGG analysis, and cell-cell adhesion, calcium ion transmembrane transport by GO analysis. A proportion of DMR-associated genes were involved in calcium signaling pathways. The methylation changes of calcium signaling genes might be related to VSD pathogenesis. Conclusion: CHD is associated with differential DNA methylation in MZ twins. CHD may be etiologically linked to DNA methylation, and methylation of calcium signaling genes may be involved in the development of VSD.

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Section: Differentially Methylated Regions (Dmrs) Of Vsdmentioning

confidence: 99%