A Special Haemophilic Syndrome

A Congenital Inhibitor against Factor IX

“…A study of the family revea led a consanguinity seven generations ago (4). A blood relatior'.ship w ith a n y other known Swiss bleeders couldn' t be found.…”

“…Activity of intermediate product I in per cent is referred to a normal system. 4. Rapid generation test according to Matter (18).…”

Autoantibodies reacting with heart muscle tissue in coronary heart disease

“…According to the investigations by workers in Hungary and abroad (Butler and Moeschlin, 1956;Dobias, Ballo, Bertalan, and Lorant, 1965 a, b;Ehrenfeld, Gery, and Davies, 1961; Van der Geld, 1964;Hess, Fink, Taranta, and Ziff, 1964;Kleinsorge and Dornbusch, 1960;Osztovics and Szutrdly, 1960;Osztovics, Marcsek, and Szasz, 1962;Osztovics and Marcsek, 1962;Polzer and Steffen, 1958;Robinson and Brigden, 1963) circulating autoantibodies reacting with heart muscle tissue can be demonstrated in certain heart diseases although their clinical significance is not yet clear. Some authors claim that they might play a pathogenetic role in the postpericardiotomy and postmyocardial infarction syndromes (Dressler, 1959;Van der Geld, 1964;Robinson and Brigden, 1963), but this hypothesis could not be proved unequivocally by animal experiments (Davies, Laufer, Gery and Rosenmann, 1964;Gery, Davies, and Ehrenfeld, 1960;Kaplan, 1958;Kaplan and Craig, 1963); on the other hand, the presence of these antibodies, especially in coronary disease is not accompanied by clinical symptoms, which would confirm their pathogenetic role.…”