A Spatial Transcriptomics Based Label‐Free Method for Assessment of Human Stem Cell Distribution and Effects in a Mouse Model of Lung Fibrosis
Jeongbin Park,
Dongjoo Lee,
Jae Eun Lee
et al.
Abstract:Recently, cell therapy has emerged as a promising treatment option for various disorders. Given the intricate mechanisms of action (MOA) and heterogenous distribution in target tissues inherent to cell therapy, it is necessary to develop more sophisticated, unbiased approaches to evaluate the distribution of administered cells and the molecular changes at a microscopic level. This study introduces a label‐free approach for assessing the tissue distribution of administered human mesenchymal stem cells (hMSCs) a… Show more
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