A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice

Zhao, Jianhong; Sun, Suzhen; Horiguchi, Hyogo; Arao, Yukitomo; Kanamori, Namiko; Kikuchi, Atsumi; Oguma, Etsuko; Kayama, Fujio

doi:10.1016/j.intimp.2005.04.011

Cited by 21 publications

(9 citation statements)

References 36 publications

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“…The same group has demonstrated evidence of improved markers of cardiovascular risk in diabetic nephropathy patients, but the impact on actual health outcomes is yet to be determined. 39,40 Stephenson et al 41 demonstrated a beneficial effect on glomerular hyperfiltration in young adults with type 1 diabetes with well-preserved renal function, a finding supported by mouse studies and studies on type 2 diabetes patients by Teixeira et al 42,43 Zhao et al 44 have, however, found acceleration of renal injury in a murine model of systemic lupus erythematosus, and urge caution in patients with immunological renal injury.…”

Section: Discussionmentioning

confidence: 90%

Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet

Ogborn

Nitschmann²,

Bankovic-Calic³

et al. 2010

Exp Biol Med (Maywood)

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Soy diet ameliorates renal injury in the Han:SPRD-cy rat. The relative roles of protein, isoflavones and changes in polyunsaturated fatty acid (PUFA) status are not determined. We fed male Han:SPRD-cy heterozygotes casein (C), high isoflavone soy protein (HIS), alcohol-extracted low isoflavone soy protein (LIS) or mixed soy protein diet (MIS). LIS and MIS were associated with a small decrease in animal weight compared with HIS or C. Soy diets preserved normal renal function and reduced relative renal weight (10.9-14.6 g/kg, cf. 23.6, P < 0.001), scores for cystic change (0.168-0.239, cf. 0.386, P < 0.05), fibrosis (0.013-0.015, cf. 0.032, P < 0.05), tissue oxidized LDL content (0.012-0.021, cf. 0.048, P < 0.05), inflammation (8.5-12.9, cf. 31.2, P < 0.05) and epithelial cell proliferation (6.5-13.8, cf. 26.3, P < 0.05). In post hoc testing, LIS produced a greater reduction in relative renal weight, cystic change and epithelial proliferation, whereas HIS produced a significantly greater reduction in oxidized-LDL. Soy diets were associated with increased hepatic content of 18C PUFA (P < 0.001). LIS and HIS diets were associated with a small increase in body fat content (P < 0.001). Alcohol-extracted soy protein retains its major protective effects in this model with subtle differences attributable to isoflavones.

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Section: Discussionmentioning

confidence: 90%

Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet

Ogborn

Nitschmann²,

Bankovic-Calic³

et al. 2010

Exp Biol Med (Maywood)

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“…It should be noted that there is some conflict regarding the effects of phytoestrogens of soy on immune disorders. A mouse model study on lupus disease reported that a soy diet compared to a casein diet worsened the clinical course of lupus [101]. ASU could also be useful to treat inflammatory bowel disease.…”

Section: Autoimmune Disordersmentioning

confidence: 99%

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

et al. 2020

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Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado–soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.

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“…17,32 However, potent adverse effects of isofl avones on the immune response of mice have also been reported. 33 Zhao et al 33 have reported that a soybean-rich diet can exacerbate renal damages, increasing serum creatinine and reducing the creatinine clearance, which increase the severity of the glomerular disease in MPL/lpr mice. The results have shown that soybean can accelerate glomerulonephritis, but improves the proliferative function of T cells.…”

Section: Isofl Avonesmentioning

confidence: 99%

“…The results have shown that soybean can accelerate glomerulonephritis, but improves the proliferative function of T cells. 33 On the other hand, Hong et al 32 have shown that the supplementation with isofl avones increased the survival of SLE murine models, inhibiting the production of autoantibodies (anti-dsDNA and anticardiolipin), and reducing the secretion of IFN-γ. Those authors have also reported that isofl avones have anti-infl ammatory properties and antioxidant effects.…”

Section: Isofl Avonesmentioning

confidence: 99%

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

Klack

Bonfá²,

Borba³

2012

Rev. Bras. Reumatol.

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The authors reviewed the infl uence of nutritional factors on systemic lupus erythematosus (SLE) and discussed an alternative treatment option. The autoimmunity and infl ammatory process of SLE are related to the presence of dyslipidemia, obesity, systemic arterial hypertension, and metabolic syndrome, which should be properly considered to decrease cardiovascular risk. A diet with moderate protein and energy content, but rich in vitamins, minerals (especially antioxidants), and mono/ polyunsaturated fatty acids can promote a benefi cial protective effect against tissue damage and suppression of infl ammatory activity, in addition to helping the treatment of those comorbidities. Diet therapy is a promising approach and some recommendations may offer a better quality of life to patients with SLE.

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A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice

Cited by 21 publications

References 36 publications

Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet

Dietary soy protein benefit in experimental kidney disease is preserved after isoflavone depletion of diet

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

Dieta e aspectos nutricionais no lúpus eritematoso sistêmico

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