A Sore Throat—Potentially Life-Threatening?

Li, Haiyan; Grubb, Mandy; Panda, Mukta; Jones, Roger

doi:10.1007/s11606-009-1001-1

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…Following antibiotic discovery, the incidence has decreased over three decades with only 40 cases identified between 1950 and 1995 with only two cases between 1980 and 1990s) as was found by Leuger and Clover 9. This has led to Lemierre's being termed: ‘the forgotten disease’ 9 13. However, over the past 15 years, the incidence has been increasing and it has been suggested this may be secondary to decrease in antibiotic use, to better diagnostic facilities and more worryingly to antibiotic resistance 2 4 13.…”

Section: Discussionmentioning

confidence: 99%

“…This has led to Lemierre's being termed: ‘the forgotten disease’ 9 13. However, over the past 15 years, the incidence has been increasing and it has been suggested this may be secondary to decrease in antibiotic use, to better diagnostic facilities and more worryingly to antibiotic resistance 2 4 13. Death rate preantibiotics time was 90% 9 12.…”

Section: Discussionmentioning

confidence: 99%

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Just a sore throat? Uncommon causes of significant respiratory disease

2013

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SUMMARYWe present two uncommon underlying causes of a sore throat which, if missed or delayed in diagnosis, can lead to disastrous consequences. Our first case is of Lemierre's syndrome diagnosed in a 21-year-old man presenting with a 5-day history of sore throat, fever, right-sided pleuritic chest pain and bilateral pulmonary nodules on CT imaging. Fusobacterium necrophorum cultured from peripheral blood and an occluded left internal jugular vein on ultrasound lead to an eventual diagnosis. Our second case presents a 29-year-old woman with a 5-day history of sore throat, fever and right-sided pleuritic chest pain. A left-sided quinsy was diagnosed and aspirated and the patient was discharged home. She represented shortly with worsening pleuritic pain and was found to have a right-sided pleural effusion with descending mediastinitis originating from the tonsillar abscess. Delayed diagnosis resulted in open thoracotomy, decortication and prolonged intravenous antibiotics. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Just a sore throat? Uncommon causes of significant respiratory disease

2013

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“…Although a conservative approach is appropriate for most patients with acute pharyngitis, clinicians should recognize the red flags in young adults with sore throat, including neck pain, unilateral neck swelling, and pulmonary symptoms. 11,14 If such factors are present, a more aggressive approach is warranted, which includes obtaining blood cultures, imaging to evaluate for internal jugular thrombophlebitis, and initiating early antimicrobial coverage for anaerobes. 15 …”

Section: 11mentioning

confidence: 99%

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et al. 2014

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“…Se recomienda el uso empírico de antibiótico resistente a betalactamasas (fórmulas que contengan clavulánico o sulbactam) hasta obtener los resultados del antibiograma. 9,13,14 Una alternativa es la monoterapia con clindamicina. Se administra por vía endovenosa hasta que desaparezcan la fiebre y el dolor cervical, y se continúa por vía oral hasta completar de 2 a 6 semanas de tratamiento.…”

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“…Se administra por vía endovenosa hasta que desaparezcan la fiebre y el dolor cervical, y se continúa por vía oral hasta completar de 2 a 6 semanas de tratamiento. 13,14 La anticoagulación es controvertida. Hay autores que contraindican su uso por el riesgo de diseminación de la infección.…”

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Trombosis de la vena yugular interna secundaria a faringoamigdalitis aguda

2014

Arch Argent Pediat

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Presentación de casos clínicos RESUMENLa faringoamigdalitis aguda es una de las enfermedades más comunes en niños y adolescentes. La etiología más frecuente es la viral, seguida por la bacteriana. Entre las causas bacterianas, el principal agente es el estreptococo beta hemolítico del grupo A. Una complicación infrecuente de los procesos infecciosos faríngeos es la tromboflebitis séptica de la vena yugular interna. El diagnóstico se sospecha ante la tumefacción laterocervical unilateral de carácter inflamatorio. Se confirma mediante tomografía computada con contraste. El tratamiento consiste en la administración prolongada de antibióticos; el uso de anticoagulantes es controvertido. El diagnóstico precoz y el tratamiento apropiado son esenciales para evitar la oclusión vascular persistente y la progresión del trombo, que puede ocasionar émbolos pulmonares. Presentamos a una adolescente con tromboflebitis de la vena yugular interna secundaria a faringoamigdalitis aguda estreptocócica, con el objetivo de describir las manifestaciones clínicas, los métodos diagnósticos y el tratamiento de esta rara complicación vascular. Palabras clave: trombosis de la vena yugular interna, faringitis aguda. ABSTRACTAcute pharyngotonsillitis is one of the most common diseases in children and adolescents. The most frequent etiology is virus, followed by bacteria. The main bacterial agent is beta hemolytic Streptococcus group A. A rare complication of pharyngeal infectious processes is septic thrombophlebitis of the internal jugular vein. The diagnosis is suspected in the presence of an inflammatory unilateral neck swelling. The diagnosis is confirmed by contrast computed tomography. Treatment consists of prolonged administration of antibiotics, being the use of anticoagulants controversial. Early diagnosis and appropriate treatment are essential to prevent persistent vascular occlusion and progression of the thrombus, which can cause pulmonary emboli. In the present study, we present a teenager with thrombophlebitis of the internal jugular vein secondary to acute streptococcal pharyngotonsillitis. Clinical manifestations, diagnostic methods and treatment of this rare vascular complication are described herein. Key words: thrombosis of the internal jugular vein, acute pharyngitis. Trombosis de la vena yugular interna secundaria a faringoamigdalitis agudaThrombosis of the internal jugular vein secondary to acute pharyngotonsillitis

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A Sore Throat—Potentially Life-Threatening?

Cited by 7 publications

References 18 publications

Just a sore throat? Uncommon causes of significant respiratory disease

Just a sore throat? Uncommon causes of significant respiratory disease

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Trombosis de la vena yugular interna secundaria a faringoamigdalitis aguda

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