A Solvent Vapor, Carbon Disulfide

Tissue Disposition of Carbon Disulfide: I. Whole‐body Autoradiography of 35S‐ and 14C‐labelled Carbon Disulfide in Adult Male Mice

“…Low-temperature autoradiography of C3 5S2 and I4CS2 indicated that CS2 itself disappeared relatively rapidly from the tissues, since the lowtemperature autoradiograms showed the same distribution patterns of radioactivity as autoradiograms obtained by a conventional technique at all survival times longer than 2 hours. This finding is supported by earlier observations of a rapid exhalation of CS2 by both man (McKee et al. 1943;Teisinger & Soucek 1949) and experimental animals (McKee et al 1943;DeMatteis & Seawright 1973;McKenna & DiStefano 1977;Dalvi & Neal 1978).…”

“…This finding is supported by earlier observations of a rapid exhalation of CS2 by both man (McKee et al. 1943;Teisinger & Soucek 1949) and experimental animals (McKee et al 1943;DeMatteis & Seawright 1973;McKenna & DiStefano 1977;Dalvi & Neal 1978). The short retention time for CS2 itself in the body would indicate that there is little risk of accumulation of CS2 in the tissues at repeated exposure.…”

The effect of carbon disulphide convulsions on a conditioned emotional response.

“…Nor did ether anesthesia, added to the effects of the CS2 convulsions in group I, produce any greater attenuation in the CER than CSa convulsions alone produced; groups I and II showed only small and nonsignificant differences after treatment. These negative findings on the effects of CS a vapor and ether anesthesia are interesting because of the inhibitory influence both substances are supposed to have upon cerebral metabolism (4,9,15,18). It is not impossible, however, that either or both might turn out to have a very small effect on the CER, if a more sensitive test could be devised.…”