A Soluble Ribonucleic Acid Intermediate in Protein Synthesis

Hoagland, Mahlon B.; Stephenson, Mary L.; Scott, Jesse F.; Hecht, Liselotte I.; Zamecnik, Paul C.

doi:10.1016/s0021-9258(19)77302-5

Cited by 727 publications

(111 citation statements)

References 16 publications

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“…Single stranded RNA or ssDNA aptamers are not linear "tapes" but 3-dimensional shapes as illustrated by the discovery of tRNA 56 by Paul Zamecnik, Mary Louise Stephenson and colleagues at MGH, HMS. Publication of the discovery of tRNA by Zamecnik in 1958 catalyzed an array of milestones including the discovery of mRNA by Brenner 57 and Gros 58 as well as the lac operon model of feedback inhibition by Jacob and Monod 59 , all three published in 1961.…”

Section: Prevention Follows Detection and Diagnosticsmentioning

confidence: 99%

Aptamers for Detection and Diagnostics (ADD) is a proposed mobile app acquiring optical data from conjugated quantum nanodots to identify molecules indicating presence of SARS-CoV-2 virus: Why public health and healthcare need smartphone sensors as a platform for early detection and prevention

Datta

2021

Preprint

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Proposed SARS-CoV-2 surveillance tool using a mobile app for non-invasive monitoring of humans and animals. <p>Engineering a biomedical device as a low-cost, non-invasive, detection, and diagnostic platform for surveillance of infections in humans, and animals. The system embraces the IoT <i>“digital by design”</i> metaphor by incorporating elements of connectivity, data sharing and (secure) information arbitrage. Using an array of aptamers to bind viral targets may help in detection, diagnostics, and potentially prevention in case of SARS-CoV-2. The ADD tool may become part of a broader platform approach.</p>

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Section: Prevention Follows Detection and Diagnosticsmentioning

confidence: 99%

Aptamers for Detection and Diagnostics (ADD) is a proposed mobile app acquiring optical data from conjugated quantum nanodots to identify molecules indicating presence of SARS-CoV-2 virus: Why public health and healthcare need smartphone sensors as a platform for early detection and prevention

Datta

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Single stranded RNA or ssDNA aptamers are not linear "tapes" but 3-dimensional shapes as illustrated by the discovery of tRNA 57 by Paul Zamecnik, Mary Louise Stephenson and colleagues at MGH, HMS. Publication of the discovery of tRNA by Zamecnik in 1958 catalyzed an array of milestones including the discovery of mRNA by Brenner 58 and Gros 59 as well as the lac operon model of feedback inhibition by Jacob and Monod 60 , all three published in 1961.…”

Section: Prevention Follows Detection and Diagnosticsmentioning

confidence: 99%

Aptamers for Detection and Diagnostics (ADD) is a proposed mobile app acquiring optical data from conjugated quantum nanodots to identify molecules indicating presence of SARS-CoV-2 virus: Why public health and healthcare need smartphone sensors as a platform for early detection and prevention

Datta

2021

Preprint

View full text Add to dashboard Cite

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“…Since their discovery, tRNAs have been considered as passive carriers of amino acids during translation and their putative regulatory role had been overlooked, until recently [2,209]. Nowadays, tRNAs represent a dynamic population of essential noncoding RNAs with diverse regulatory roles and profound impact on human health [31].…”

Section: The Emerging Role Of Trna Biology and Trfs In Skin Cancermentioning

confidence: 99%

Translation Regulation in Skin Cancer from a tRNA Point of View

et al. 2018

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Protein synthesis is a central and dynamic process, frequently deregulated in cancer through aberrant activation or expression of translation initiation factors and tRNAs. The discovery of tRNA-derived fragments, a new class of abundant and, in some cases stress-induced, small noncoding RNAs has perplexed the epigenomics landscape and highlights the emerging regulatory role of tRNAs in translation and beyond. Skin is the biggest organ in human body, which maintains homeostasis of its multilayers through regulatory networks that induce translational reprogramming, and modulate tRNA transcription, modification and fragmentation, in response to various stress signals, like UV irradiation. In this review, we summarize recent knowledge on the role of translation regulation and tRNA biology in the alarming prevalence of skin cancer.

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A Soluble Ribonucleic Acid Intermediate in Protein Synthesis

Cited by 727 publications

References 16 publications

Aptamers for Detection and Diagnostics (ADD) is a proposed mobile app acquiring optical data from conjugated quantum nanodots to identify molecules indicating presence of SARS-CoV-2 virus: Why public health and healthcare need smartphone sensors as a platform for early detection and prevention

Aptamers for Detection and Diagnostics (ADD) is a proposed mobile app acquiring optical data from conjugated quantum nanodots to identify molecules indicating presence of SARS-CoV-2 virus: Why public health and healthcare need smartphone sensors as a platform for early detection and prevention

Aptamers for Detection and Diagnostics (ADD) is a proposed mobile app acquiring optical data from conjugated quantum nanodots to identify molecules indicating presence of SARS-CoV-2 virus: Why public health and healthcare need smartphone sensors as a platform for early detection and prevention

Translation Regulation in Skin Cancer from a tRNA Point of View

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