A soluble and heat-resistant form of hantavirus nucleocapsid protein for the serodiagnosis of HFRS

Park, Sang Myun; Kim, Jongsun

doi:10.1016/j.jviromet.2007.08.001

Cited by 2 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subunit vaccines : Orthohantavirus Gn/Gc and N proteins could elicit a strong humoral immune response [ 207 , 208 , 209 ]. Gn/Gc proteins could induce neutralizing antibody response [ 210 ], while N protein activates non-neutralizing antibody [ 211 ].…”

Section: Vaccines and Prevention Of Hantavirus Infectionsmentioning

confidence: 99%

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Sehgal

Mehta

Sahay

et al. 2023

Viruses

View full text Add to dashboard Cite

Hemorrhagic Fever with Renal Syndrome (HFRS) is the most frequently diagnosed zoonosis in Asia. This zoonotic infection is the result of exposure to the virus-contaminated aerosols. Orthohantavirus infection may cause Hemorrhagic Fever with Renal Syndrome (HRFS), a disease that is characterized by acute kidney injury and increased vascular permeability. Several species of orthohantaviruses were identified as causing infection, where Hantaan, Puumala, and Seoul viruses are most common. Orthohantaviruses are endemic to several Asian countries, such as China, South Korea, and Japan. Along with those countries, HFRS tops the list of zoonotic infections in the Far Eastern Federal District of Russia. Recently, orthohantavirus circulation was demonstrated in small mammals in Thailand and India, where orthohantavirus was not believed to be endemic. In this review, we summarized the current data on orthohantaviruses in Asia. We gave the synopsis of the history and diversity of orthohantaviruses in Asia. We also described the clinical presentation and current understanding of the pathogenesis of orthohantavirus infection. Additionally, conventional and novel approaches for preventing and treating orthohantavirus infection are discussed.

show abstract