A solitary giant neurofibroma of inguinal region: A case report

Abstract

Neurofibroma is a rare nerve sheath tumor of neuroectodermal origin, especially the huge and isolated neurofibroma located in the inguinal region. To our knowledge, no such case has previously been reported. We report a case of 34-year-old male patient with a 4-year history of progressive enlargement of the medial root mass in his left thigh with sitting and standing disorders along with pain. The tumor was completely removed by operation, and pathological diagnosis showed neurofibroma. There was no obvious neurologic defect after surgery, and no recurrence tendency was found in the follow-up of 2 years. For a large solitary mass with slow growth and no malignant clinical manifestations for a long time, clinicians cannot rule out the hypothetical diagnosis of neurofibroma, even though its growth site is very rare, such as this case of a huge tumor located in the groin. For neurogenic tumors, early operation should be performed, and the prognosis of patients after tumor resection is excellent.

Solitary Retroperitoneal Neurofibroma Associated With Deep Vein Thrombosis in a 40-Year-Old Male

“…Neurofibromas are the most prevalent benign peripheral NSTs [ 7 ]. They account for 5% of all benign soft tissue tumors [ 8 ]. Our case presents the findings of a rare variant that was not only sporadic but also retroperitoneal.…”

“…Njoumi et al published a case of a 29-year-old male with a solitary preperitoneal neurofibroma [ 9 ]. Other case reports have reported even more distinct locations of neurofibromas including the hard palate [ 10 ], the inguinal region [ 8 ], and the retroperitoneal pelvic area [ 11 ]. Considering the above, it is evident that solitary neurofibromas have the propensity to develop anywhere in the body.…”

“…Evidently, neurofibromas present with a wide range of clinical manifestations and are usually incidental findings that become symptomatic only when they enlarge sufficiently to impinge on surrounding structures [ 11 ]. For any large solitary mass with slow growth and no signs of malignancy, a neurofibroma should always be included in the differential [ 8 ]. This, along with schwannoma, liposarcoma, and lymphoma made up our differential diagnosis.…”

“…Regardless of the severity of presenting symptoms, efforts should always be made for prompt diagnosis of any suspected retroperitoneal mass in order to prevent detrimental complications [ 5 ]. Late diagnosis of intra-pelvic tumors may also lead to surgical resection difficulties and an overall poor prognosis [ 8 ]. For example, in the previously mentioned case of retroperitoneal schwannoma resulting in DVT, an exploratory laparotomy was done, only to find that the tumor was heavily adherent to the sacrum and also displaced the bladder and recto-sigmoid colon, which prevented excision at that time and re-exploration at a later date was necessitated [ 12 ].…”

“…The diagnosis of neurofibromas depends on various imaging modalities with MRI and CT scans being the most widely utilized [ 8 ]. Preoperative imaging, however, is usually insufficient to diagnose with certainty and a biopsy is typically warranted for confirmation with histopathology [ 9 ].…”