A solid virilizing granulosa cell tumour

Dhont, Marc; Duvivier, Patricia; Vandekerckhove, D

doi:10.1016/0028-2243(85)90073-5

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The most common gross appearance in virilizing granulosa cell tumor was a solid mass in approximately 14 patients (3,4,12,13–18,21–23) , a cystic mass in 10 patients (9,11,17,19,20) , a mixed solid/cystic mass in 4 patients (4,8,17,24) , and a multiloculated cyst in 2 patients (6,7) . The tumor in our case was also a thin‐walled, multilocular cyst.…”

Section: Discussionmentioning

confidence: 57%

“…The most common clinical symptoms were hirsutism, amenorrhea, abdominal mass, and deepening of the voice. In more than half of the cases, elevated serum or plasma levels of testosterone were reported (7,9,11–15,18–24) . After tumor removal, the androgenic clinical findings usually disappeared and plasma testosterone levels returned to normal limits (11–14,17,19–24) .…”

Section: Discussionmentioning

confidence: 99%

“…Granulosa cell tumors are usually associated with manifestation of hyperestrogenism and are rarely associated with virilization. Considering all age groups, less than 35 cases of virilizing adult‐type granulosa cell tumors have been reported in the literature (3–24) . So far, only two such cases have been reported in patients under 15 years of age (20,23) .…”

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confidence: 99%

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Androgenic adult granulosa cell tumor in a teenager: a case report and review of the literature

Kabaca¹,

Karateke²,

Gürbüz³

et al. 2006

International Journal of Gynecological Cancer

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The clinicopathologic findings of the third case of androgenic adult granulosa cell tumor in patients younger than 15 years was presented and discussed in the light of the literature. A patient complaining of secondary amenorrhea and hirsutism with elevated levels of plasma total testosterone, dehydroepiandrosterone sulfate, free androgen index and serum inhibin A, and a left ovarian septated, cystic mass was admitted to the hospital. The inhibin A level was within normal levels in the first month postoperatively. Inhibin A could be a tumor marker of utmost importance particularly in patients with androgenic or hyperestrogenic symptoms, especially in cases where benign criteria are abundant such as young age, nonincreased levels of classic tumor markers, and ultrasonographic appearance without any suspicion of malignancy.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Androgenic adult granulosa cell tumor in a teenager: a case report and review of the literature

Kabaca¹,

Karateke²,

Gürbüz³

et al. 2006

International Journal of Gynecological Cancer

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Androgenic Adult Granulosa Cell Tumor in a 13-Year-Old Prepubertal Patient: A Case Report and Review of the Literature

Castro

Malpica

Hearne

et al. 2000

International Journal of Gynecological Pathology

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We report the clinicopathologic findings of an unusual case of adult granulosa cell tumor with androgenic manifestation in a 13-year-old prepubertal girl. The patient had never had a menstrual period and presented with a 1 year history of hirsutism. Physical examination was only remarkable for an increase in facial and abdominal hair, both with a male pattern of distribution. A pelvic ultrasound demonstrated a 6.0 cm right adnexal cyst. Plasma testosterone and 17-hydroxyprogesterone levels were elevated. The patient initially was treated with monophasic oral contraceptive pills for 3 months and owing to lack of response, she underwent an exploratory laparotomy in which a left ovarian tumor, 7.0 cm in greatest dimension, and a 6.5 cm right paratubal cyst were found. A wedge biopsy of the left ovary and subsequent left oophorectomy with right salpingectomy were performed. No gross evidence of disease outside the ovary was noted. Microscopic examination of the left ovarian tumor revealed the typical features of an adult granulosa cell tumor. No tumor was seen outside the ovary. Six days after surgery, plasma testosterone and 17-hydroxyprogesterone levels were in the normal range. Nine months postoperatively, the patient shows no evidence of disease. To our knowledge, this represents the first case of a prepubertal patient with an adult granulosa cell tumor with androgenic manifestations reported in the English literature.

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