A solid-phase fluoroimmunoassay for human IgE

Blanchard, G. C.; Gardner, Rosalie E.

doi:10.1016/0022-1759(82)90352-0

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…IgA was measured on the Beckman nephelometer. IgE by fluoroimmunoassay [35]. Soluble E-receptor suppressor factor was measured in the laboratory of Dr. Se-Kyunp Oh by radioimmunoassay [22].…”

Section: Methodsmentioning

confidence: 99%

Plasma exchange in six patients with advanced cancers of the head and neck

Seder

Katz

Keggins

et al. 1985

J of Clinical Apheresis

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Six patients with advanced squamous cell cancers of the head and neck, with serum IgA greater than or equal to 400 mg/dl and IgE less than or equal to 1000 IU/ml, underwent a trial of six 2-liter plasma exchanges over a 2-3-week period. Disease progressed in patients 1, 2, and 4, who died on days 44, 72, and 159. The tumor in patients 3 and 6 regressed significantly, repeatedly in patient 3 over each of four courses of apheresis. Tumor recurred in both patients after cessation of treatment, and they died at days 420 and 79. Patient 5, with inoperable disease, received full-dose radiotherapy immediately following the course of apheresis, and showed complete response in the primary lesion and a major response in the extensive lymph node metastases, dying on day 421 of apparently unrelated causes. Serum IgE in the three patients experiencing tumor regression rose paradoxically during plasmapheresis. Only patient 3 had an elevated level of soluble E-receptor suppressor factor prepheresis; the serum of patient 6 was lymphocytotoxic prepheresis but this activity decreased or disappeared during each of the exchanges studied. Controlled trials are now indicated.

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Section: Methodsmentioning

confidence: 99%

Plasma exchange in six patients with advanced cancers of the head and neck

Seder

Katz

Keggins

et al. 1985

J of Clinical Apheresis

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Tumor regression and temporary restoration of immune response after plasmapheresis in a patient with recurrent oral cancer

Seder¹,

Vaughan²,

Oh³

et al. 1987

Cancer

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A major response to plasmapheresis is reported in a patient with advanced, recurrent squamous cell cancer of the oral cavity, similar to that previously reported in three of six comparable patients. Tumor regression followed temporary reduction of inhibition of normal lymphocyte response to phytohemag-glutinin (PHA) by the patient's serum (from 99% to zero) and partial restoration of the patient's lymphocyte response (from 2% to 38% of control). The IgE level rose both overall and during some exchanges; this correlate of tumor response had been noted earlier. The tumor showed extensive necrosis, but the clinical effects were relatively short-lived and the patient died 11 weeks later. Biopsy specimens taken early in apheresis showed intense new infiltration of tumor by lymphocytes and monocytes; later biopsy specimens showed predominantly plasma cells with trapping and lysis of tumor cells. No other anti-cancer therapies had been used for 16 months before this trial, and no replacements were given other than saline and albumin. Cancer 60:318-325, 1987. HE IMMUNE SYSTEM interacts in many ways with T neoplastic diseases, but its significance in the etiol-ogy and/or therapy of cancer remains unclear. Deficiencies in both cell-mediatedlT2 and h ~ m o r a l ~ , ~ immune responses have been demonstrated in tumor bearing subjects. Immune complexes5-' and a variety of other humoral factors8-" have been investigated as possible causes for these deficiencies. Reduction in the activity of circulating immunosuppressive factors, whether of host or tumor origin, should, in theory, strengthen the host's anti-tumor response. This study was carried out at the

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In Vitro assays for jrnmunogiobulir E

Johansson

Yman

1988

Clinical Reviews in Allergy

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A solid-phase fluoroimmunoassay for human IgE

Cited by 5 publications

References 15 publications

Plasma exchange in six patients with advanced cancers of the head and neck

Plasma exchange in six patients with advanced cancers of the head and neck

Tumor regression and temporary restoration of immune response after plasmapheresis in a patient with recurrent oral cancer

In Vitro assays for jrnmunogiobulir E

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