A Software Framework for Creating Patient Specific Geometric Models from Medical Imaging Data for Simulation Based Medical Planning of Vascular Surgery

Wilson, Nathan M.; Wang, Kenneth; Dutton, R.W.; Taylor, Charles A.

doi:10.1007/3-540-45468-3_54

Cited by 116 publications

(105 citation statements)

References 6 publications

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“…1). 20 Using the computer model, a computational fluid dynamics (CFD) analysis was performed to simulate blood flow and blood pressure. 21,22 In this analysis, additional patient-specific flow data [cine phase-contrast magnetic resonance imaging (PC-MRI)] at the supraceliac and infrarenal levels and pressure data (brachial pressure cuff measurements acquired immediately after the scan) were considered in order to model the baseline flow and pressure conditions in this patient as accurately as possible.…”

Section: Methodsmentioning

confidence: 99%

Effect of Curvature on Displacement Forces Acting on Aortic Endografts: A 3-Dimensional Computational Analysis

Figueroa

Taylor

Yeh

et al. 2009

Journal of Endovascular Therapy

111

114

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¤ ¤Purpose: To determine the effect of curvature on the magnitude and direction of displacement forces acting on aortic endografts in 3-dimensional (3D) computational models.Method: A 3D computer model was constructed based on magnetic resonance angiography data from a patient with an infrarenal aortic aneurysm. Computational fluid dynamics tools were used to simulate realistic flow and pressure conditions of the patient. An aortic endograft was deployed in the model, and the displacement forces acting on the endograft were calculated and expressed in Newtons (N). Additional models were created to determine the effects of reducing endograft curvature, neck angulation, and iliac angulation on displacement forces. Results: The aortic endograft had a curved configuration as a result of the patient's anatomy, with curvature in the anterolateral direction. Total displacement force acting on the endograft was 5.0 N, with 28% of the force in a downward (caudal) direction and 72% of the force in a sideways (anterolateral) direction. Elimination of endograft curvature (planar graft configuration) reduced total displacement force to 0.8 N, with the largest component of force (70%) acting in the sideways direction. Straightening the aortic neck in the curved endograft configuration reduced the total force acting on the endograft to 4.2 N, with a reduction of the sideways component to 55% of the total force. Straightening the iliac limbs of the endograft reduced the total force acting on the endograft to 2.1 N but increased the sideways component to 91% of the total force. Conclusion: The largest component of the force acting on the aortic endograft is in the sideways direction, with respect to the blood flow, rather than in the downward (caudal) direction as is commonly assumed. Increased curvature of the aortic endograft increases the magnitude of the sideways displacement force. The degree of angulation of the proximal and distal ends of the endograft influence the magnitude and direction of displacement force. These factors may have a significant influence on the propensity of endografts to migrate in vivo.

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Section: Methodsmentioning

confidence: 99%

Effect of Curvature on Displacement Forces Acting on Aortic Endografts: A 3-Dimensional Computational Analysis

Figueroa

Taylor

Yeh

et al. 2009

Journal of Endovascular Therapy

111

114

View full text Add to dashboard Cite

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“…Each volume of MRA data was corrected by using proprietary software (GE Medical Systems, Milwaukee, WI) for known gradient nonlinearities during acquisition that can cause distortion in the slice direction (4). Three-dimensional, subject-specific solid models of the aorta and its major branches (celiac, superior mesenteric, and renal arteries) were created from the MRA images using custom software (41) and discretized by using a commercially available, automatic mesh generation program (MeshSim, Simmetrix, Clifton Park, NY). Figure 1 summarizes the model construction procedure from MR data to creating a finite element mesh.…”

Section: Methodsmentioning

confidence: 99%

Abdominal aortic hemodynamics in young healthy adults at rest and during lower limb exercise: quantification using image-based computer modeling

Tang

Cheng²,

Draney³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

123

109

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. Abdominal aortic hemodynamics in young healthy adults at rest and during lower limb exercise: quantification using image-based computer modeling. Am J Physiol Heart Circ Physiol 291: H668 -H676, 2006. First published April 7, 2006 doi:10.1152/ajpheart.01301.2005.-Localization of atherosclerotic lesions in the abdominal aorta has been previously correlated to areas of adverse hemodynamic conditions, such as flow recirculation, low mean wall shear stress, and high temporal oscillations in shear. Along with its many systemic benefits, exercise is also proposed to have local benefits in the vasculature via the alteration of these regional flow patterns. In this work, subject-specific models of the human abdominal aorta were constructed from magnetic resonance angiograms of five young, healthy subjects, and computer simulations were performed under resting and exercise (50% increase in resting heart rate) pulsatile flow conditions. Velocity fields and spatial variations in mean wall shear stress (WSS) and oscillatory shear index (OSI) are presented. When averaged over all subjects, WSS increased from 4.8 Ϯ 0.6 to 31.6 Ϯ 5.7 dyn/cm 2 and OSI decreased from 0.22 Ϯ 0.03 to 0.03 Ϯ 0.02 in the infrarenal aorta between rest and exercise. WSS significantly increased, whereas OSI decreased between rest and exercise at the supraceliac, infrarenal, and suprabifurcation levels, and significant differences in WSS were found between anterior and posterior sections. These results support the hypothesis that exercise provides localized benefits to the cardiovascular system through acute mechanical stimuli that trigger longer-term biological processes leading to protection against the development or progression of atherosclerosis. atherosclerosis; shear stress; magnetic resonance imaging; finite element analysis ADVERSE HEMODYNAMIC conditions, such as complex, recirculating flow, low mean wall shear stress, high spatial gradients in shear stress, and high particle residence times, are hypothesized to contribute to the localization of atherosclerotic plaque throughout the vasculature. In the abdominal aorta, a correlation between atherosclerosis and areas of low wall shear stress has been elucidated with prior autopsy (2,7,27,31,39) and experimental studies (5,16,19,20,22,32). Specifically, Cornhill et al. (2) observed a high probability of occurrence of sudanophilic lesions along the posterior and lateral walls of autopsy specimens obtained from young, healthy males, whereas Roberts et al. (27) and Glagov et al. (21), and in vitro cell culture work has shown that oscillating shear can induce an inflammatory response, including an increase in reactive oxygen species (3,9,29).Conversely, elevated blood flow associated with exercise has been hypothesized to result in hemodynamic conditions that inhibit atherosclerosis, such as unidirectional laminar flow, increased wall shear stress, and enhanced transport of cholesterol from the vessel wall (11,18,32,33). It has been shown in vitro that the vascular endothelium can sense and resp...

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“…Network compression was enhanced by getting close to walls. Also in the location of grafting (bypass input and output) and blockage location (area contraction) network compression was utilized more 14 . Figure 2 shows the sample of used network in following study.…”

Section: Methodsmentioning

confidence: 99%

Evaluating the Effect of Magnetic Field, Impulse Flow and Gravity Acceleration on Different Femoral Bypass Angles in Order to Remove Lipid Accumulations in Atherosclerosis Disease by Simulation Method

Ghenaat¹,

Moghadam²

2016

Biosci., Biotech. Res. Asia

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Aterosclerosis and obstructions especially in great and vital arteries cause blood circulation system numerous disorders. Coronary arteries, carotid and femoral as the most important arteries could be affected negatively by aterosclerosis which may result in shock or heart attack. Bypass surgical operation is a significant method to treat clogged arteries nowadays and should be designed as perfect as it would minimize flow turbulence. Numeral simulation techniques are among the most recommended methods to reach this purpose. While most of researchers considered blood as a Newtonian fluid and none has studied magnetic field effect on bypass, we aimed to evaluate blood flow as a non-Newtonian fluid in presence of magnetic field and gravity acceleration in different bypass angels. A model of three-dimensional femoral artery with bypass and rigid wall was assumed. Percentages of blockage was defined by following formula; [(A i -A s )/A i ] in which A i was non-blockage area, and A s was the artery's narrowest part area. Desired geometry was modeled by SolidWorks software then networked in Gambit software. There were three different equations applied including: Equation of the artery in the blockage area, sinusoidal relationship based on Reynolds number and fluid equation of continuity and momentum. Magnetic force of blood flow acted as a resistant tensional force and in presence of magnetic field normal blood flow was observed and subsequently outward viscosity was increased. Magnetic field also caused thickening boundary layer and as velocity gradient increased close to the walls shear stress enhanced. When magnetic field increased and Hartmann number enhanced subsequently there was no observation of negative shear stress. In the bypass entrance a returned flow occurred. By developing the Hartmann number vortex power decreased so that in 10 and 20 Hartmann returned flow was vanished completely. All of hemodynamic parameters and environmental factors that affect them are necessary to improve the efficiency of bypass surgical operations. If the three-dimensional modeling approaches maximally match with the reality they could help the specialists to choose the best location and angel of the bypass and improve the achievement probability significantly.

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A Software Framework for Creating Patient Specific Geometric Models from Medical Imaging Data for Simulation Based Medical Planning of Vascular Surgery

Cited by 116 publications

References 6 publications

Effect of Curvature on Displacement Forces Acting on Aortic Endografts: A 3-Dimensional Computational Analysis

Effect of Curvature on Displacement Forces Acting on Aortic Endografts: A 3-Dimensional Computational Analysis

Abdominal aortic hemodynamics in young healthy adults at rest and during lower limb exercise: quantification using image-based computer modeling

Evaluating the Effect of Magnetic Field, Impulse Flow and Gravity Acceleration on Different Femoral Bypass Angles in Order to Remove Lipid Accumulations in Atherosclerosis Disease by Simulation Method

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