A Soft Tissue Myxoma on the Palate: A Case Report

Abstract

Myxomas in the orofacial regions are relatively uncommon tumors that occur in two different types: odontogenic myxomas and soft tissue myxomas. Odontogenic myxomas, derived from the mesenchymal cells such as papillae, dental follicles, or periodontal ligament, occur commonly in the maxilla and mandible. However, soft tissue myxomas in the oral cavity are rare and have been previously reported in only about 30 cases of unknown pathogenesis. The aim of this case report is to present a new case of oral soft tissue myxoma in a 37-year-old male patient who presented with a soft, exophytic round mass on the palate.

A Nerve Sheath Myxoma (Soft Tissue Myxoma) of the Lower Lip: Rare Case Study

“…The most frequent site of involvement in the oral cavity was the palate, the next site was the buccal mucosa, followed by the lips and the floor of the mouth according to a report done by [1] and [10]. Nisi et al [9] reported more cases of nerve sheath myxomas given the palate followed by buccal mucosa the most frequent sites.…”

“…In the head and neck regions, odontogenic type and soft tissue type are considered the forms of myxoma seen. Odontogenic types are benign growths originating from mesenchymal cells such as dental papillae, or periodontium, which present more frequently than soft tissue counterparts in both jaws (maxilla and mandible) [1]. Peripheral (soft tissue) myxomas are a group of contrastive soft tissue tumors with a similar histological presentation of copious myxoid material in their background [1], [4].…”

“…Odontogenic types are benign growths originating from mesenchymal cells such as dental papillae, or periodontium, which present more frequently than soft tissue counterparts in both jaws (maxilla and mandible) [1]. Peripheral (soft tissue) myxomas are a group of contrastive soft tissue tumors with a similar histological presentation of copious myxoid material in their background [1], [4]. Soft tissue myxomas are considered a growth of primitive undifferentiated mesenchymal cells of perineural origin or nerve cell origin [2], [5].…”

“…The differential diagnosis for soft tissue myxoma is lipoma, fibroepithelial polyp, fibroma, and salivary gland tumor [8], [9]. Histopathological examination with immune stains is the only way to get a precise diagnosis of these lesions [1], [2].…”

“…Nerve sheath myxoma (neurothekeoma), is identified as a benign tumor of nerve sheath. Which was described initially as a cutaneous lesion with benign behavior and a pattern of neural growth which gave it initially the name nerve sheath myxoma followed later by the name Neurothekeoma [1]. Nerve sheath myxoma mostly seen on the head and neck region but rarely in the lower lip [2], [3].…”