A socioeconomic lens on understanding early childhood linear growth faltering

Baumann, Shyon; Majeed, Hamnah; Majeed, Haris

doi:10.1016/s2214-109x(18)30039-1

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Further, in our study no socioeconomic and lifestyle data were available for our studied individuals. Although in Canada the cost of prophylaxis is covered by the provincial government, socioeconomic status plays an important role in children and adolescents' day-to-day life, where it is known that children raised in low socioeconomic status result in poor health outcomes, 33,34 including the lack of adequate nutrition from their diet resulting in underdevelopment of their skeleton and cartilage. 35 Also, due to the lack of data, the level of physical activity among hemophilic and healthy individuals was not considered in this study.…”

Section: Limitationsmentioning

confidence: 99%

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T₂ Mapping

Majeed

Ahmed

Sussman

et al. 2020

Magnetic Resonance Imaging

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Background Persons with hemophilia experience hemarthrosis, which can lead to cartilage degeneration, causing physical impairment. MRI T2 mapping has the potential to be used as a tool to evaluate early arthropathic changes and cartilage degeneration in patients with hemophilia. Purpose To assess the value of MRI‐T2 mapping as a tool for investigating the cartilage status of children and adolescents with hemophilic arthropathy. Study Type Prospective, cross‐sectional. Subjects Twenty‐eight boys with hemophilia (aged 5–17 years) and 23 healthy boys (aged 7–17 years). Field Strength/Sequences A multiecho spin‐echo T2‐weighted gradient echo sequence was used on a 3.0T magnet. Assessment MRI‐T2 maps of ankle (tibia‐talus) (n = 19) or knee (femur‐tibia) (n = 9) cartilage were assessed in hemophilia and healthy groups. An anatomically‐based MRI score was also assigned to each ankle/knee. Statistical Tests Pearson's correlation coefficient (r), linear regression, intraclass correlation coefficient (ICC), and analysis of variance (ANOVA) test. Results Negative associations between age and ankle/knee cartilage T2 relaxation times were found in hemophilia (r = –0.72 [P = 0.03] to –0.55 [P = 0.01]) and healthy (r = –0.84 [P < 0.001] to –0.55 [P = 0.20]) groups. There were nonsignificant associations between ankle cartilage T2 relaxation times and MRI scores (r = –0.15 [P = 0.54] to 0.31 [P = 0.19]). Data Conclusion Results of this clinical investigation emphasize the potential importance of MRI‐T2 maps as a tool to understand the functional status of cartilage in children and adolescents with hemophilic arthropathy, while holding promise for the detection of early cartilage degeneration prior to macroscopic characterization by conventional MRI. MRI‐T2 mapping may provide novel information that is not reflected in the anatomically‐based MRI scoring system. Level of Evidence 3 Technical Efficacy Stage 2

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Section: Limitationsmentioning

confidence: 99%

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T₂ Mapping

Majeed

Ahmed

Sussman

et al. 2020

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

A socioeconomic lens on understanding early childhood linear growth faltering

Cited by 1 publication

References 7 publications

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T₂ Mapping

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T₂ Mapping

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A socioeconomic lens on understanding early childhood linear growth faltering

Cited by 1 publication

References 7 publications

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T2 Mapping

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Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T₂ Mapping

Understanding Early Hemophilic Arthropathy in Children and Adolescents Through MRI T₂ Mapping