A SNP within the PMCH gene as a molecular marker associated with fertility traits in Angus and Brangus beef heifers raised under a desert environment

Angulo-Valenzuela, Norberto Ismael; Thomas, M. G.; Riley, David G.; Medrano, Juan F.; Reyna-Granados, Javier R.; Aguilar-Trejo, C. M.; Luna‐Nevárez, Pablo

doi:10.1007/s11250-021-02794-0

Cited by 4 publications

(2 citation statements)

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“…These findings indicate that BDKRB1 is involved in inflammation, and we cannot rule out an association between BDKRB1 and SIG. PMCH is proteolyzed to produce various peptides, including the appetite hormone melanin-concentrating hormone (MCH) [43] . It is related to many fundamental physiological processes, such as stress response, metabolic regulation and sleep [44] .…”

Section: Hub Genes Bdkrb1 Rna Were Low In the Experimentalmentioning

confidence: 99%

Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

Miao¹,

Huang²,

Zhang³

et al. 2022

Int J Ophthalmol

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AIM: To investigate potential gene changes in trabecular meshwork (TM) induced by dexamethasone (DEX) in steroid-induced glaucoma (SIG). METHODS: The expression data of 24 cases from a public functional genomics data were sorted to identify the mechanisms of action of DEX on the TM. The relationships of the differentially expressed genes (DEGs) were enriched using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. In addition, the hub genes were screened by the Search Tool for the Retrieval of Interacting Genes Database (STRING) and Cytoscape tools. Finally, human TM cells (HTMCs) were treated with DEX to preliminarily explore the function of hub genes. RESULTS: Totally 47 DEGs, including 21 downregulated and 26 upregulated genes were identified. The primary enriched results of the DEGs consisted of inflammatory response, extracellular matrix (ECM), negative regulation of cell proliferation, TNF signalling pathway and the regulation of tryptophan channels by inflammatory mediators. Subsequently, pro-melanin-enriched hormone (PMCH) and Bradykinin B1 receptor (BDKRB1) were screened as hub genes. It is verified in GSE37474 data set. Western blot and quantitative real-time polymerase chain reaction (qPCR) results showed that protein and RNA expression levels of BDKRB1 were significantly decreased after DEX treatment, while PMCH was not significantly changed. CONCLUSION: BDKRB1 may be a key gene involved in SIG onset, providing a suitable therapeutic target for improving the prognosis of SIG patients.

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Section: Hub Genes Bdkrb1 Rna Were Low In the Experimentalmentioning

confidence: 99%

Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

Miao¹,

Huang²,

Zhang³

et al. 2022

Int J Ophthalmol

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“…Mecanismos genéticos que regulan la respuesta animal ante los efectos térmicos extremos pueden ser evaluados a través de estudios asociativos de genoma completo (GWAS) combinados con estudios para la validación de marcadores y genes candidatos (Macciota et al, 2017). Estas tecnologías han permitido la identificación de marcadores moleculares en genes candidatos asociados a indicadores de termo-tolerancia (Luna-Nevárez et al, 2020, fertilidad (Luna-Nevárez et al, 2011;Angulo-Valenzuela et al, 2021), crecimiento (Weng et al, 2016) y caracteres de calidad de la canal (Peters et al, 2013). Regiones genómicas han sido reportadas como asociadas a procesos de adaptación y resistencia a los efectos del cambio climático en ovinos (Tsartsianidou et al, 2021).…”

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Tecnologías moleculares ómicas aplicadas al estudio del estrés por calor en ganado

Reyna-Granados

Luna-Ramirez

Limesand

et al. 2022

ALPA

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The ability to tolerate extreme heat has been proposed as an important selection criterion to promote the breeding of thermo-tolerant animals, especially in climates characterized by environmental heat stress during most of the year. Novel genomic technologies are available to study genetic bases supporting the thermo-tolerance in cattle, among which are: Genome-wide association studies, validation of markers and candidate genes, RNA sequencing and transcriptome analysis. These technologies currently allow faster progress in the identification of thermotolerant cattle, which is highly relevant from the perspective of the current problems as global warming and food security. So, the objective of this review is to analyze the current status of the use of omics technologies in animal production studies under heat stress.

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Molecular markers for thermo-tolerance are associated with reproductive and physiological traits in Pelibuey ewes raised in a semiarid environment

Castillo-Salas

Reyna-Granados

Luna-Ramirez

et al. 2023

Journal of Thermal Biology

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A SNP within the PMCH gene as a molecular marker associated with fertility traits in Angus and Brangus beef heifers raised under a desert environment

Cited by 4 publications

References 14 publications

Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

Expression profile analysis to identify potential gene changes induced by dexamethasone in the trabecular meshwork

Tecnologías moleculares ómicas aplicadas al estudio del estrés por calor en ganado

Molecular markers for thermo-tolerance are associated with reproductive and physiological traits in Pelibuey ewes raised in a semiarid environment

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